论文信息 - Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy

Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy

The influence of inclusion complex formation between cyclodextrins (chiefly the β‐polymer) and a variety of chiral antihistaminic and analgesic agents on the 1H NMR features of both guest and host partners is reported. In many cases equivalent protons of antipodes give resonances which differ in chemical shift after inclusion, and the potential value of the data to chiral analysis and to elucidation of the structures of the inclusion complexes is demonstrated.

A. Casy | A. Mercer

[1] D. Greatbanks,et al. Cyclodextrins as chiral complexing agents in water, and their application to optical purity measurements , 1987 .

[2] K. Fujioka,et al. Studies of cyclodextrin inclusion complexes. I: Complex between cyclodextrins and bencyclane in aqueous solution , 1984 .

[3] F. Podo,et al. 13C NMR studies of isomeric piperidine derivatives with opiate properties and related compounds , 1981 .

[4] Wolfram Saenger,et al. Cyclodextrin Inclusion Compounds in Research and Industry , 1980 .

[5] A. Brossi,et al. Expedient synthesis of racemic and optically active N-norreticuline and N-substituted and 6'-bromo-N-norreticulines , 1980 .

[6] D. J. Wood,et al. Proton NMR study of the inclusion of aromatic molecules in .alpha.-cyclodextrin , 1977 .

[7] D. L. Larson,et al. Stereochemical studies on medicinal agents. 12. The distinction of enantiotopic groups in the interaction of 1-methyl-4-phenyl-4-propionoxypiperidine with analgetic receptors. , 1973, Journal of medicinal chemistry.

[8] C. Kutal. CHIRAL SHIFT REAGENTS , 1973 .

[9] E. Donoghue,et al. A NEW CLASS OF HIGHLY ACTIVE ANTIHISTAMINICS , 1960 .

[10] A. Ziering,et al. Piperidine derivatives; 1,3-dialkyl-4-aryl-4-acyloxypiperidines. , 1947, The Journal of organic chemistry.