Second act

In February 2011, the British drug company AstraZeneca shelved its experimental drug zibotentan, intended for the treatment of nonmetastatic prostate cancer in men who do not respond to hormonal treatments. Despite early promise, the drug failed to improve patients’ survival in trials. But more than a year later, the drug might get a second wind, this time as a potential treatment for Alzheimer’s disease, thanks to a partnership between industry and academia. With AstraZeneca crowdsourcing the search for potential new applications for its drugs in the academic community, the partnership could lead to treatments not apparent during the original development of the drug.