Studies on new vasodilators, WS-1228 A and B. I. Discovery, taxonomy, isolation and characterization.

New vasodilators, designated WS-1228 A and B have been discovered in the culture filtrate of a strain of Streptomyces aureofaciens. The active compounds were purified by column chromatography with Diaion HP-20 and silica gel, and finally separated from each other by high performance liquid chromatography. They were obtained as pale yellow crystals and their molecular formulae were both C11H17N3O.

[1]  J. Vane.  THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOOD , 1997, British journal of pharmacology and chemotherapy.

[2]  J. Vane,et al.  The technique of superfusion , 1997, British journal of pharmacology and chemotherapy.

[3]  H. Imanaka,et al.  Studies on new vasodilators, WS-1228 A and B. II. Structure and synthesis. , 1982, Journal of antibiotics (Tokyo. 1968).

[4]  H. Imanaka,et al.  Structure and synthesis of a new hypotensive vasodilator isolated from Streptomyces aureofaciens , 1981 .

[5]  P. Schindler.  Enzyme inhibitors of microbial origin. , 1980, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

[6]  H. B. Woodruff,et al.  Natural products from microorganisms. , 1980, Science.

[7]  P. Needleman,et al.  Coronary tone modulation: formation and actions of prostaglandins, endoperoxides, and thromboxanes. , 1977, Science.

[8]  E. B. Shirling,et al.  Cooperative description of type cultures of Streptomyces. IV. Species descriptions from the second, third and fourth studies** , 1969 .

[9]  E. B. Shirling,et al.  Cooperative Description of Type Cultures of STREPTOMYCES III. Additional Species Descriptions from First and Second Studies , 1968 .

[10]  E. B. Shirling,et al.  Cooperative description of type cultures of Streptomyces.: II. Species descriptions from first study , 1968 .

[11]  E. B. Shirling,et al.  Methods for characterization of Streptomyces species , 1966 .

[12]  K. Eiter,et al.  Synthese der vier isomeren Hexadecadien‐(10.12)‐ole‐(1) , 1962 .

[13]  W. Emmons,et al.  The Utility of Phosphonate Carbanions in Olefin Synthesis , 1961 .

[14]  T. G. Pridham,et al.  The Utilization of Carbon Compounds by Some Actinomycetales as an Aid for Species Determination , 1948, Journal of bacteriology.

[15]  S. Waksman.  The Actinomycetes. Vol. II. Classification, Identification and Descriptions of Genera and Species. , 1961 .