Transporter–metabolism interplay in the eye

Abstract: In the past few years, several efflux transporters and metabolizing enzymes have been recognized to restrict ocular drug absorption. In this chapter, we have made an attempt to provide an overview of healthy and disease state impact on the expression of metabolizing enzymes. Moreover, we have also discussed the potential interplay between membrane transporters and metabolizing enzymes within ocular tissues and strategies to circumvent these processes.

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