Variable pulsed light is less painful than light‐emitting diodes for topical photodynamic therapy of actinic keratosis: a prospective randomized controlled trial

Background  Photodynamic therapy (PDT) of actinic keratosis (AK) using methylaminolaevulinate (MAL) is an effective and safe treatment option, but the procedure is painful.

[1]  Karel Berka,et al.  Methodological Problems of Measurement , 1983 .

[2]  Petras Juzenas,et al.  Effectiveness of different light sources for 5-aminolevulinic acid photodynamic therapy , 2004, Lasers in Medical Science.

[3]  R. M. Szeimiesa,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002 .

[4]  M. Goldman,et al.  Intense pulsed light as a nonablative approach to photoaging. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[5]  V. Belo,et al.  Effectiveness of Photodynamic Therapy with Topical 5‐Aminolevulinic Acid and Intense Pulsed Light versus Intense Pulsed Light Alone in the Treatment of Acne Vulgaris: Comparative Study , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[6]  J. Nelson,et al.  Photodynamic therapy of actinic keratosis with topical 5-aminolevulinic acid. A pilot dose-ranging study. , 1997, Archives of dermatology.

[7]  M. Gold,et al.  Treatment of sebaceous gland hyperplasia by photodynamic therapy with 5-aminolevulinic acid and a blue light source or intense pulsed light source. , 2004, Journal of drugs in dermatology : JDD.

[8]  S. Ibbotson,et al.  Topical 5‐aminolaevulinic acid photodynamic therapy for cutaneous lesions: outcome and comparison of light sources , 2003, Photodermatology, photoimmunology & photomedicine.

[9]  G. Altshuler,et al.  Intense pulsed light and laser treatment of facial telangiectasias and dyspigmentation: some theoretical and practical comparisons. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[10]  Ann-Marie Wennberg,et al.  Guidelines on the use of photodynamic therapy for nonmelanoma skin cancer: an international consensus. International Society for Photodynamic Therapy in Dermatology, 2005. , 2007, Journal of the American Academy of Dermatology.

[11]  M. Landthaler,et al.  Photodynamic therapy with topical application of 5-aminolevulinic acid in the treatment of actinic keratoses: an initial clinical study. , 1996, Dermatology.

[12]  P Lehmann,et al.  Preferential Relative Porphyrin Enrichment in Solar Keratoses upon Topical Application of ^‐Aminolevulinic Acid Methylester , 1998, Photochemistry and photobiology.

[13]  CLAUDE C. FRAZIER,et al.  PHOTODYNAMIC THERAPY IN DERMATOLOGY , 1996, International journal of dermatology.

[14]  M. Goldman,et al.  Effectiveness and safety of ALA-IPL in treating actinic keratoses and photodamage. , 2004, Journal of drugs in dermatology : JDD.

[15]  D. Salomon,et al.  Photodynamic therapy using topical methyl 5-aminolevulinate compared with cryotherapy for actinic keratosis: A prospective, randomized study. , 2002, Journal of the American Academy of Dermatology.

[16]  J. Moan,et al.  Photodynamic Therapy of Superficial Basal Cell Carcinoma with 5-Aminolevulinic Acid with Dimethylsulfoxide and Ethylendiaminetetraacetic Acid: A Comparison of Two Light Sources , 2000, Photochemistry and photobiology.

[17]  H. Moseley,et al.  Laser and Non-laser Light Sources for Photodynamic Therapy , 2002, Lasers in Medical Science.

[18]  E. Tanzi,et al.  Photorejuvenation of facial skin with topical 20% 5-aminolevulinic acid and intense pulsed light treatment: a split-face comparison study. , 2005, Journal of drugs in dermatology : JDD.

[19]  O P Tandon,et al.  Pain measurement: a formidable task. , 2002, Indian journal of physiology and pharmacology.

[20]  J. Ring,et al.  Photodynamic therapy induces less pain in patients treated with methyl aminolevulinate compared to aminolevulinic acid. , 2006, Journal of drugs in dermatology : JDD.

[21]  J. Callen,et al.  A double-blind, vehicle-controlled study evaluating masoprocol cream in the treatment of actinic keratoses on the head and neck. , 1991, Journal of the American Academy of Dermatology.

[22]  M. Gold,et al.  The use of a novel intense pulsed light and heat source and ALA-PDT in the treatment of moderate to severe inflammatory acne vulgaris. , 2004, Journal of drugs in dermatology : JDD.

[23]  S. Melnick.  Cystic acne improved by photodynamic therapy with short-contact 5-aminolevulinic acid and sequential combination of intense pulsed light and blue light activation. , 2005, Journal of drugs in dermatology : JDD.

[24]  K. Arndt,et al.  Topical 5-aminolevulinic acid combined with intense pulsed light in the treatment of photoaging. , 2005, Archives of dermatology.

[25]  P. Bjerring,et al.  Intense pulsed light source for the treatment of dye laser resistant port‐wine stains , 2003, Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology.

[26]  Hyung Su Kim,et al.  Topical Photodynamic Therapy Using Intense Pulsed Light for Treatment of Actinic Keratosis: Clinical and Histopathologic Evaluation , 2005, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[27]  E. Ross.  Laser versus intense pulsed light: Competing technologies in dermatology , 2006, Lasers in surgery and medicine.

[28]  E. Ohnhaus,et al.  Methodological problems in the measurement of pain: A comparison between the verbal rating scale and the visual analogue scale , 1975, PAIN.

[29]  M. Lebwohl,et al.  A double-blind, vehicle-controlled study of clobetasol propionate 0.05% (Temovate) scalp application in the treatment of moderate to severe scalp psoriasis. , 1991, Journal of the American Academy of Dermatology.

[30]  P. Speight,et al.  Photodynamic therapy of malignant and premalignant lesions in patients with ’field cancerization‘ of the oral cavity , 1993, The Journal of Laryngology & Otology.

[31]  D. Moher,et al.  The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomised trials , 2001, The Lancet.

[32]  A. Sharifian,et al.  A comparison study of the efficacy and side effects of different light sources in hair removal , 2006, Lasers in Medical Science.

[33]  M. Landthaler,et al.  In vitro and in vivo comparison of two different light sources for topical photodynamic therapy , 2006, The British journal of dermatology.

[34]  M Landthaler,et al.  A possible new incoherent lamp for photodynamic treatment of superficial skin lesions. , 1994, Acta dermato-venereologica.

[35]  M. Goldman,et al.  Treatment of Poikiloderma of Civatte with an Intense Pulsed Light Source , 2000, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[36]  H. Hönigsmann,et al.  Photodynamic therapy of epithelial skin tumours using delta‐aminolaevulinic acid and desferrioxamine , 1995, The British journal of dermatology.

[37]  Carin Sandberg,et al.  Important factors for pain during photodynamic therapy for actinic keratosis. , 2006, Acta dermato-venereologica.

[38]  Hans Christian Wulf,et al.  Pain associated with photodynamic therapy using 5-aminolevulinic acid or 5-aminolevulinic acid methylester on tape-stripped normal skin. , 2003, Archives of dermatology.

[39]  B. Pogue,et al.  Transient absorption changes in vivo during photodynamic therapy with pulsed-laser light , 1999, British Journal of Cancer.

[40]  R. Ruiz-Rodríguez,et al.  Photodynamic Photorejuvenation , 2002, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].

[41]  M. Landthaler,et al.  Long‐pulse dye laser for photodynamic therapy: Investigations in vitro and in vivo , 1999, Lasers in surgery and medicine.

[42]  H Kerl,et al.  Primary clinical response and long-term follow-up of solar keratoses treated with topically applied 5-aminolevulinic acid and irradiation by different wave bands of light. , 1997, Journal of photochemistry and photobiology. B, Biology.

[43]  J. Chung,et al.  Photo-epilation results of axillary hair in dark-skinned patients by intense pulsed light: comparison between different wavelengths and pulse width. , 2006, Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].