Friends or foes — bipolar effects of the tumour stroma in cancer

[1]  G. Gabbiani,et al.  Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction , 1971, Experientia.

[2]  N. Fusenig,et al.  Cooperative Autocrine and Paracrine Functions of Granulocyte Colony-Stimulating Factor and Granulocyte-Macrophage Colony-Stimulating Factor in the Progression of Skin Carcinoma Cells , 2004, Cancer Research.

[3]  F. Kabbinavar,et al.  Bevacizumab in combination with 5-FU/leucovorin improves survival in patients with metastatic colorectal cancer: A combined analysis. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[4]  E. Bruyneel,et al.  Tenascin‐C and SF/HGF produced by myofibroblasts in vitro provide convergent proinvasive signals to human colon cancer cells through RhoA and Rac , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[5]  M. Lange,et al.  Expression of G-CSF and GM-CSF in Human Meningiomas Correlates with Increased Tumor Proliferation and Vascularization , 2004, Journal of Neuro-Oncology.

[6]  J. Foidart,et al.  Membrane associated proteases and their inhibitors in tumour angiogenesis , 2004, Journal of Clinical Pathology.

[7]  J. Scheuermann,et al.  Diagnostic and therapeutic applications of recombinant antibodies: targeting the extra-domain B of fibronectin, a marker of tumor angiogenesis. , 2004, Current pharmaceutical design.

[8]  Kenneth J. Hillan,et al.  Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer , 2004, Nature Reviews Drug Discovery.

[9]  R. Weinberg,et al.  Reconstruction of functionally normal and malignant human breast tissues in mice. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[10]  R. DuBois,et al.  COX-2 inhibition and colorectal cancer. , 2004, Seminars in oncology.

[11]  Bonnie F. Sloane,et al.  Proteases, extracellular matrix, and cancer: a workshop of the path B study section. , 2004, The American journal of pathology.

[12]  V. Weaver,et al.  Watch thy neighbor: cancer is a communal affair , 2004, Journal of Cell Science.

[13]  Ana M Soto,et al.  The stroma as a crucial target in rat mammary gland carcinogenesis , 2004, Journal of Cell Science.

[14]  P. Speight,et al.  Tumour-derived TGF-β1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells , 2004, British Journal of Cancer.

[15]  M. Washington,et al.  TGF-ß Signaling in Fibroblasts Modulates the Oncogenic Potential of Adjacent Epithelia , 2004, Science.

[16]  F. Andriani,et al.  Basement membrane proteins promote progression of intraepithelial neoplasia in 3‐dimensional models of human stratified epithelium , 2004, International journal of cancer.

[17]  H. Reulen,et al.  Locoregional radioimmunotherapy in selected patients with malignant glioma: experiences, side effects and survival times , 2003, Journal of Neuro-Oncology.

[18]  A. Harris,et al.  Tumor-Associated Macrophages in Breast Cancer , 2002, Journal of Mammary Gland Biology and Neoplasia.

[19]  Takashi Sato,et al.  Tumor-stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. , 2004, Gynecologic oncology.

[20]  N. Hiraiwa,et al.  Tenascin‐C regulates angiogenesis in tumor through the regulation of vascular endothelial growth factor expression , 2004, International journal of cancer.

[21]  J. Pollard.  Tumour-educated macrophages promote tumour progression and metastasis , 2004, Nature Reviews Cancer.

[22]  T. DeWeese,et al.  The Diet, Prostate Inflammation, and the Development of Prostate Cancer , 2004, Cancer and Metastasis Reviews.

[23]  H. Dvorak,et al.  Fibrin as a component of the tumor stroma: origins and biological significance , 2004, Cancer and Metastasis Reviews.

[24]  F. Shepherd,et al.  Targeting angiogenesis: a review of angiogenesis inhibitors in the treatment of lung cancer. , 2003, Lung cancer.

[25]  M. Salgaller.  Technology evaluation: bevacizumab, Genentech/Roche. , 2003, Current opinion in molecular therapeutics.

[26]  R. Kalluri,et al.  Integrin α1β1 and α2β1 Are the Key Regulators of Hepatocarcinoma Cell Invasion Across the Fibrotic Matrix Microenvironment , 2003 .

[27]  P. Kuppen,et al.  NK cells and the tumour microenvironment: implications for NK-cell function and anti-tumour activity. , 2003, Trends in immunology.

[28]  R. D. del Maestro,et al.  Soluble factors involved in glioma invasion , 2003, Acta Neurochirurgica.

[29]  J. Folkman,et al.  Fundamental concepts of the angiogenic process. , 2003, Current molecular medicine.

[30]  S. Hayward,et al.  Role of the stromal microenvironment in carcinogenesis of the prostate , 2003, International journal of cancer.

[31]  S. Toda,et al.  Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer–stromal cell interactions , 2003, The Journal of pathology.

[32]  S. Swain,et al.  Ongoing adjuvant trials with trastuzumab in breast cancer. , 2003, Seminars in oncology.

[33]  Seth M Steinberg,et al.  A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. , 2003, The New England journal of medicine.

[34]  Olivier De Wever,et al.  Role of tissue stroma in cancer cell invasion , 2003, The Journal of pathology.

[35]  S. Werner,et al.  Regulation of wound healing by growth factors and cytokines. , 2003, Physiological reviews.

[36]  D. Gotley,et al.  Tumor progression in hepatocellular carcinoma: Relationship with tumor stroma and parenchymal disease , 2003, Journal of gastroenterology and hepatology.

[37]  R. Kalluri.  Basement membranes: structure, assembly and role in tumour angiogenesis , 2003, Nature reviews. Cancer.

[38]  I. Fidler,et al.  The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited , 2003, Nature Reviews Cancer.

[39]  Rakesh K Jain,et al.  Molecular regulation of vessel maturation , 2003, Nature Medicine.

[40]  T. Sakakura,et al.  Tenascin‐C upregulates matrix metalloproteinase‐9 in breast cancer cells: Direct and synergistic effects with transforming growth factor β1 , 2003, International journal of cancer.

[41]  C. Berking,et al.  Function and regulation of melanoma–stromal fibroblast interactions: when seeds meet soil , 2003, Oncogene.

[42]  J. Pringle,et al.  There is more than one kind of myofibroblast: analysis of CD34 expression in benign, in situ, and invasive breast lesions , 2003, Journal of clinical pathology.

[43]  P. Ricchi,et al.  Nonsteroidal anti-inflammatory drugs in colorectal cancer: from prevention to therapy , 2003, British Journal of Cancer.

[44]  J. Foidart,et al.  Membrane type-1 matrix metalloproteinase and TIMP-2 in tumor angiogenesis. , 2003, Matrix biology : journal of the International Society for Matrix Biology.

[45]  J. Campisi,et al.  Integrating epithelial cancer, aging stroma and cellular senescence. , 2002, Advances in gerontology = Uspekhi gerontologii.

[46]  N. Fusenig,et al.  Tumor-stroma interactions directing phenotype and progression of epithelial skin tumor cells. , 2002, Differentiation; research in biological diversity.

[47]  A. Csoka,et al.  Hyaluronidase reduces human breast cancer xenografts in SCID mice , 2002, International journal of cancer.

[48]  F. X. Bosch,et al.  Environmental co-factors in HPV carcinogenesis. , 2002, Virus research.

[49]  J. Folkman,et al.  Clinical translation of angiogenesis inhibitors , 2002, Nature Reviews Cancer.

[50]  R. Iozzo,et al.  Suppression of tumorigenicity by adenovirus-mediated gene transfer of decorin , 2002, Oncogene.

[51]  D. Burns,et al.  Neurofibromas in NF1: Schwann Cell Origin and Role of Tumor Environment , 2002, Science.

[52]  M. Bissell,et al.  The dominance of the microenvironment in breast and ovarian cancer. , 2002, Seminars in cancer biology.

[53]  Lei Xu,et al.  Tumour biology: Herceptin acts as an anti-angiogenic cocktail , 2002, Nature.

[54]  J. Tonn,et al.  Microtumor growth initiates angiogenic sprouting with simultaneous expression of VEGF, VEGF receptor-2, and angiopoietin-2. , 2002, The Journal of clinical investigation.

[55]  Constance E. Brinckerhoff,et al.  Matrix metalloproteinases: a tail of a frog that became a prince , 2002, Nature Reviews Molecular Cell Biology.

[56]  Z. Werb,et al.  New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.

[57]  M. Skobe,et al.  Tissue Models to Study Tumor-Stroma Interactions , 2002 .

[58]  J. Foidart,et al.  Proteases and Their Inhibitors in Cancer Metastasis , 2002, Cancer Metastasis — Biology and Treatment.

[59]  R. Bookstein,et al.  Evaluation of endostatin antiangiogenesis gene therapy in vitro and in vivo , 2001, Cancer Gene Therapy.

[60]  W. Linehan,et al.  The consequences of chromosomal aneuploidy on gene expression profiles in a cell line model for prostate carcinogenesis. , 2001, Cancer research.

[61]  B. Weeks,et al.  Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis. , 2001, Cancer research.

[62]  J. Garlick,et al.  Tumor progression of skin carcinoma cells in vivo promoted by clonal selection, mutagenesis, and autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. , 2001, The American journal of pathology.

[63]  L. Matrisian,et al.  Matrix metalloproteinases: they're not just for matrix anymore! , 2001, Current opinion in cell biology.

[64]  S. Inoue,et al.  Cancer-associated myofibroblasts possess various factors to promote endometrial tumor progression. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

[65]  B. Olsen,et al.  The role of collagen-derived proteolytic fragments in angiogenesis. , 2001, Matrix biology : journal of the International Society for Matrix Biology.

[66]  Elise C. Kohn,et al.  The microenvironment of the tumour–host interface , 2001, Nature.

[67]  T. Tlsty,et al.  Stromal cells can contribute oncogenic signals. , 2001, Seminars in cancer biology.

[68]  W. Stetler-Stevenson,et al.  Proteases in invasion: matrix metalloproteinases. , 2001, Seminars in cancer biology.

[69]  Andrew V. Nguyen,et al.  Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy , 2001, The Journal of experimental medicine.

[70]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[71]  J. Ringel,et al.  Transforming Growth Factor-β1 Induces Desmoplasia in an Experimental Model of Human Pancreatic Carcinoma , 2001 .

[72]  N. Fusenig,et al.  Differential stromal regulation of MMP-1 expression in benign and malignant keratinocytes. , 2001, The Journal of investigative dermatology.

[73]  Anthony Atala,et al.  Continuous release of endostatin from microencapsulated engineered cells for tumor therapy , 2001, Nature Biotechnology.

[74]  J. Lawler.  The functions of thrombospondin-1 and-2. , 2000, Current opinion in cell biology.

[75]  P. Carmeliet,et al.  Angiogenesis in cancer and other diseases , 2000, Nature.

[76]  Sanford H Barsky,et al.  Human breast carcinoma desmoplasia is PDGF initiated , 2000, Oncogene.

[77]  J. Tonn,et al.  Targeting angiogenesis inhibits tumor infiltration and expression of the pro‐invasive protein SPARC , 2000, International journal of cancer.

[78]  R. Kalluri,et al.  Distinct Antitumor Properties of a Type IV Collagen Domain Derived from Basement Membrane* , 2000, The Journal of Biological Chemistry.

[79]  G. Bratthauer,et al.  Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. , 2000, Cancer research.

[80]  M. Barcellos-Hoff,et al.  Irradiated mammary gland stroma promotes the expression of tumorigenic potential by unirradiated epithelial cells. , 2000, Cancer research.

[81]  P. Hein,et al.  Carcinoma-associated fibroblasts stimulate tumor progression of initiated human epithelium , 2000, Breast Cancer Research.

[82]  D. Hanahan,et al.  The Hallmarks of Cancer , 2000, Cell.

[83]  N. Fusenig,et al.  Matrix Metalloproteinases-2, -3, -7, -9 and -10, But Not MMP-11, Are Differentially Expressed in Normal, Benign Tumorigenic and Malignant Human Keratinocyte Cell Lines , 2000, Biological chemistry.

[84]  J. Park,et al.  Fibroblast Activation Protein, a Dual Specificity Serine Protease Expressed in Reactive Human Tumor Stromal Fibroblasts* , 1999, The Journal of Biological Chemistry.

[85]  N. Fusenig,et al.  Constitutive expression of G‐CSF and GM‐CSF in human skin carcinoma cells with functional consequence for tumor progression , 1999, International journal of cancer.

[86]  T. Saida,et al.  Increased synthesis of hyaluronate enhances motility of human melanoma cells. , 1999, The Journal of investigative dermatology.

[87]  N. Fusenig,et al.  Autocrine growth regulation by granulocyte colony-stimulating factor and granulocyte macrophage colony-stimulating factor in human gliomas with tumor progression. , 1999, The American journal of pathology.

[88]  G. Yancopoulos,et al.  New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF , 1999, Oncogene.

[89]  A B West,et al.  Myofibroblasts: paracrine cells important in health and disease. , 2000, Transactions of the American Clinical and Climatological Association.

[90]  N. Fusenig,et al.  Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[91]  D. Powell.  Water transport revisited , 1999, The Journal of physiology.

[92]  D. Powell,et al.  Powell, D. W. et al. Myofibroblasts. I. Paracrine cells important in health and disease. Am. J. Physiol. 277, C1-C9 , 1999 .

[93]  R. Pierce,et al.  Matrix metalloproteinases generate angiostatin: effects on neovascularization. , 1998, Journal of immunology.

[94]  M. Skobe,et al.  Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization , 1998, Nature Medicine.

[95]  J. Foekens,et al.  Urokinase‐type‐plasminogen‐activator(UPA) production by human breast (myo)fibroblasts in vitro: Influence of transforming growth factor‐β1 (TGFβ1) compared with factor(s) released by human epithelial‐carcinoma cells , 1998, International journal of cancer.

[96]  P. Glazer,et al.  Mutagenesis induced by the tumor microenvironment. , 1998, Mutation research.

[97]  J. Foidart,et al.  In Vivo Evidence That the Stromelysin-3 Metalloproteinase Contributes in a Paracrine Manner to Epithelial Cell Malignancy , 1998, The Journal of cell biology.

[98]  M. Skobe,et al.  Tumorigenic conversion of immortal human keratinocytes through stromal cell activation. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[99]  R. Kerbel.  A cancer therapy resistant to resistance , 1997, Nature.

[100]  Mihaela Skobe,et al.  Halting angiogenesis suppresses carcinoma cell invasion , 1997, Nature Medicine.

[101]  A. Ekbom,et al.  Is there an excess risk for colorectal cancer in patients with ulcerative colitis and concomitant primary sclerosing cholangitis? A population based study , 1997, Gut.

[102]  N. Fusenig,et al.  Fibroblast‐directed expression and localization of 92‐kDa type IV collagenase along the tumor‐stroma interface in an in vitro three‐dimensional model of human squamous cell carcinoma , 1997, Molecular carcinogenesis.

[103]  C. Larabell,et al.  Reversion of the Malignant Phenotype of Human Breast Cells in Three-Dimensional Culture and In Vivo by Integrin Blocking Antibodies , 1997, The Journal of cell biology.

[104]  L. Meisner,et al.  A juvenile polyposis tumor suppressor locus at 10q22 is deleted from nonepithelial cells in the lamina propria. , 1997, Gastroenterology.

[105]  I. Fidler,et al.  Macrophage-Derived Metalloelastase Is Responsible for the Generation of Angiostatin in Lewis Lung Carcinoma , 1997, Cell.

[106]  William Arbuthnot Sir Lane,et al.  Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth , 1997, Cell.

[107]  D. Hanahan,et al.  Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis , 1996, Cell.

[108]  B. Kacinski,et al.  CSF-1 and its receptor in ovarian, endometrial and breast cancer. , 1995, Annals of medicine.

[109]  M. Bissell,et al.  Inflammation is responsible for the development of wound-induced tumors in chickens infected with Rous sarcoma virus. , 1994, Cancer research.

[110]  K. Smith-McCune,et al.  Demonstration and characterization of the angiogenic properties of cervical dysplasia. , 1994, Cancer research.

[111]  P. Engstrom,et al.  Chemoprevention of cancer. , 1994, Current problems in cancer.

[112]  W C Black,et al.  Advances in diagnostic imaging and overestimations of disease prevalence and the benefits of therapy. , 1993, The New England journal of medicine.

[113]  Jean Paul Thiery,et al.  Expression of smooth muscle-specific proteins in myoepithelium and stromal myofibroblasts of normal and malignant human breast tissue. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[114]  L. Old,et al.  Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[115]  S Paget,et al.  THE DISTRIBUTION OF SECONDARY GROWTHS IN CANCER OF THE BREAST. , 1889 .

[116]  A. Howell,et al.  FIBROBLASTS FROM RELATIVES OF PATIENTS WITH HEREDITARY BREAST CANCER SHOW FETAL-LIKE BEHAVIOUR IN VITRO , 1987, The Lancet.

[117]  H. Dvorak.  Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing. , 1986, The New England journal of medicine.

[118]  K. Illmensee,et al.  Totipotency and normal differentiation of single teratocarcinoma cells cloned by injection into blastocysts. , 1976, Proceedings of the National Academy of Sciences of the United States of America.

[119]  J. Bingham.  Letter: Lower oesophageal sphincter. , 1974, Lancet.

[120]  I. M. Neiman,et al.  [Inflammation and cancer]. , 1974, Patologicheskaia fiziologiia i eksperimental'naia terapiia.

[121]  D. Ab.  Pathology of tumors , 1965 .

[122]  A. D. de Oliveira.  [Pathology of tumors]. , 1965, Anais paulistas de medicina e cirurgia.

[123]  R. Billingham,et al.  Transplantation of Skin Components during Chemical Carcinogenesis with 20-Methylcholanthrene , 1951, British Journal of Cancer.

[124]  Eliot R. Clark,et al.  Microscopic observations on the growth of blood capillaries in the living mammal , 1939 .

[125]  E. Goldmann.  The Growth of Malignant Disease in Man and the Lower Animals, with special reference to the Vascular System. , 1907, Proceedings of the Royal Society of Medicine.