The presence of moisture in the air along with temperature has a long term and devastating effect on man and material. One way to create a low humidity environment is by using a solid desiccant wheel system. In the present work, an experimental analysis has been carried out under steady-state conditions to investigate the effects of different operating parameters on a solid desiccant wheel system performances. An experimental rig consists of an FFB300 air dehumidifier system was constructed. A parametric investigation was carried out to examine the effects of the reactivation air inlet temperature and process air outlet velocity on the thermal effectiveness, dehumidification efficiency, and moisture removal rate of the desiccant wheel system. The analysis shows that both thermal effectiveness and dehumidification efficiency decrease with the increase of the reactivation air inlet temperature, by 2.5 % and 43 %, respectively. Likewise, when the process air outlet velocity increases both performances criteria reduce by 10 % and 28 %, respectively. The moisture removal rate increases significantly by 30 % as the reactivation air inlet temperature increases. However, the process air outlet velocity has no significant effect on the moisture removal rate.