A Mediterranean diet supplemented with olive oil or nuts reduces the incidence of major cardiovascular events in high-risk patients

Commentary on: Estruch R, Ros E, Salas-Salvado J, et al. Primary prevention of cardiovascular disease with a Mediterranean diet. N Engl J Med 2013;368:1279–90.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] The Mediterranean diet has long been associated with lower risk for cardiovascular disease (CVD) events, which is mainly based on results from observational studies. The PREDIMED study was a well-designed, large-scale randomised trial of 7447 middle-aged participants from Spain with high cardiovascular risk but no CVD. The participants were allocated to three groups: a Mediterranean diet supplemented with extravirgin olive oil (group 1), a Mediterranean diet supplemented with nuts (group 2) and a control group that followed a healthy diet with strong advice to reduce dietary fat (group 3). The primary endpoint of the … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.issn%253D0028-4793%26rft.aulast%253DEstruch%26rft.volume%253D368%26rft.spage%253D1279%26rft.atitle%253DPrimary%2BPrevention%2Bof%2BCardiovascular%2BDisease%2Bwith%2Ba%2BMediterranean%2BDiet.%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa1200303%26rft_id%253Dinfo%253Apmid%252F23432189%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa1200303&link_type=DOI [3]: /lookup/external-ref?access_num=23432189&link_type=MED&atom=%2Febmed%2F19%2F1%2F10.atom [4]: /lookup/external-ref?access_num=000316989900005&link_type=ISI