Alterations in hepatic p53 gene methylation patterns during tumor progression with folate/methyl deficiency in the rat.

[1]  T. Hohn,et al.  Methylation of coding region alone inhibits gene expression in plant protoplasts. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[2]  M. Kastan.  Signalling to p53: where does it all start? , 1996, BioEssays : news and reviews in molecular, cellular and developmental biology.

[3]  S. Clark,et al.  Cytosine methylation: quantitation by automated genomic sequencing and GENESCAN analysis. , 1996, BioTechniques.

[4]  M. Oren,et al.  p53 in growth control and neoplasia. , 1996, Biochimica et biophysica acta.

[5]  R. Jaenisch,et al.  Germ-line passage is required for establishment of methylation and expression patterns of imprinted but not of nonimprinted genes. , 1996, Genes & development.

[6]  Benjamin Tycko,et al.  Creation of genomic methylation patterns , 1996, Nature Genetics.

[7]  J. Herman,et al.  Expression of prokaryotic HhaI DNA methyltransferase is transforming and lethal to NIH 3T3 cells. , 1996, Cancer research.

[8]  M. Szyf.  The DNA methylation machinery as a target for anticancer therapy. , 1996, Pharmacology & therapeutics.

[9]  L. Poirier,et al.  Differential sensitivity to loss of cytosine methyl groups within the hepatic p53 gene of folate/methyl deficient rats. , 1995, Carcinogenesis.

[10]  Susan J. Clark,et al.  CpNpG methylation in mammalian cells , 1995, Nature Genetics.

[11]  L. Poirier,et al.  Breaks in genomic DNA and within the p53 gene are associated with hypomethylation in livers of folate/methyl-deficient rats. , 1995, Cancer research.

[12]  S. Tornaletti,et al.  Complete and tissue-independent methylation of CpG sites in the p53 gene: implications for mutations in human cancers. , 1995, Oncogene.

[13]  R. Martienssen,et al.  DNA methylation in eukaryotes. , 1995, Current opinion in genetics & development.

[14]  N. Reich,et al.  Purification and stabilization of mouse DNA methyltransferase. , 1995, Biochemical and biophysical research communications.

[15]  T. Ono,et al.  Repression of transient expression by DNA methylation in transcribed regions of reporter genes introduced into cultured human cells. , 1995, Biochimica et biophysica acta.

[16]  R. Jaenisch,et al.  DNA methylation and cancer. , 1994, Human molecular genetics.

[17]  S. Clark,et al.  High sensitivity mapping of methylated cytosines. , 1994, Nucleic acids research.

[18]  P. Jones,et al.  Ubiquitous and tenacious methylation of the CpG site in codon 248 of the p53 gene may explain its frequent appearance as a mutational hot spot in human cancer , 1994, Molecular and cellular biology.

[19]  R. Roberts,et al.  Hhal methyltransferase flips its target base out of the DNA helix , 1994, Cell.

[20]  S. Baylin,et al.  Increased cytosine DNA-methyltransferase activity during colon cancer progression. , 1993, Journal of the National Cancer Institute.

[21]  A. Levine,et al.  A comparison of the biological activities of wild‐type and mutant p53 , 1993, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[22]  C. Wagner,et al.  DNA methylation in folate deficiency: use of CpG methylase. , 1993, Biochemical and biophysical research communications.

[23]  J. Christman,et al.  Reversibility of changes in nucleic acid methylation and gene expression induced in rat liver by severe dietary methyl deficiency. , 1993, Carcinogenesis.

[24]  J. Locker,et al.  p53 mutations in hepatocellular carcinomas induced by a choline-devoid diet in male Fischer 344 rats. , 1993, Carcinogenesis.

[25]  Peter A. Jones,et al.  High frequency mutagenesis by a DNA methyltransferase , 1992, Cell.

[26]  K. A. Lee.  Dimeric transcription factor families: it takes two to tango but who decides on partners and the venue? , 1992, Journal of cell science.

[27]  T. Bestor,et al.  Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain. , 1992, The EMBO journal.

[28]  A. Bird,et al.  Transcriptional repression by methylation of CpG , 1992, Journal of Cell Science.

[29]  T. Soussi,et al.  Structural aspects of the p53 protein in relation to gene evolution. , 1990, Oncogene.

[30]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[31]  J. Greenberg,et al.  Overproduction of peroxide‐scavenging enzymes in Escherichia coli suppresses spontaneous mutagenesis and sensitivity to redox‐cycling agents in oxyR‐mutants. , 1988, The EMBO journal.

[32]  Howard Cedar,et al.  DNA methylation affects the formation of active chromatin , 1986, Cell.

[33]  A. Niveleau,et al.  DNA methyltransferases in normal and avian sarcoma virus-transformed rat cells. Quantitation of 5-methyldeoxycytidine in DNA and enzyme kinetics study. , 1985, Biochimica et biophysica acta.

[34]  A. Feinberg,et al.  Hypomethylation of DNA from benign and malignant human colon neoplasms. , 1985, Science.

[35]  M. Ehrlich,et al.  The 5-methylcytosine content of DNA from human tumors. , 1983, Nucleic acids research.