Pairwise specificity and sequential binding in enzyme catalysis: thymidylate synthase.
暂无分享,去创建一个
[1] W. Dallas,et al. Catalytic role of histidine 147 in Escherichia coli thymidylate synthase. , 1989, The Journal of biological chemistry.
[2] G. Maley,et al. Properties of a defined mutant of Escherichia coli thymidylate synthase. , 1988, The Journal of biological chemistry.
[3] W. Dallas,et al. Functional role of cysteine-146 in Escherichia coli thymidylate synthase. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[4] R. Raines,et al. Kinetics and thermodynamics of the interaction of 5-fluoro-2'-deoxyuridylate with thymidylate synthase. , 1987, Biochemistry.
[5] R M Stroud,et al. Atomic structure of thymidylate synthase: target for rational drug design. , 1987, Science.
[6] R. Ferone,et al. alpha-Carboxyl-linked glutamates in the folylpolyglutamates of Escherichia coli. , 1986, The Journal of biological chemistry.
[7] S. P. Fodor,et al. Resonance Raman spectroscopic evidence for alternative structures in the native ternary complex formed with thymidylate synthase , 1986 .
[8] M. Moore,et al. Trapping and partial characterization of an adduct postulated to be the covalent catalytic ternary complex of thymidylate synthase. , 1986, Biochemistry.
[9] D. Santi,et al. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. , 1986, Journal of medicinal chemistry.
[10] P. Kollman,et al. An all atom force field for simulations of proteins and nucleic acids , 1986, Journal of computational chemistry.
[11] P. Danenberg,et al. Evidence from chemical degradation studies for a covalent bond from 5-fluoro-2'-deoxyuridylate to N-5 of tetrahydrofolate in the ternary complex of thymidylate synthetase-5-fluoro-2'-deoxyuridylate-5,10-methylenetetrahydrofolate. , 1985, The Journal of biological chemistry.
[12] R. Matthews,et al. Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver. , 1984, Biochemistry.
[13] P. Danenberg,et al. Spectroscopic studies of ternary complexes of thymidylate synthetase, deoxyribonucleotides, and folate analogs. , 1984, The Journal of biological chemistry.
[14] S. Benkovic,et al. Synthesis of (6R,11S)- and (6R,11R)-5,10-methylene[11-1H,2H]tetrahydrofolate. Stereochemical paths of serine hydroxymethyltransferase, 5,10-methylenetetrahydrofolate dehydrogenase, and thymidylate synthetase catalysis , 1984 .
[15] U. Singh,et al. A NEW FORCE FIELD FOR MOLECULAR MECHANICAL SIMULATION OF NUCLEIC ACIDS AND PROTEINS , 1984 .
[16] G. Maley,et al. Studies on identifying the folylpolyglutamate binding sites of Lactobacillus casei thymidylate synthetase. , 1982, Archives of biochemistry and biophysics.
[17] T. Fife,et al. General-acid catalysis of imidazolidine ring opening. The hydrolysis of ethyl N,N'-[1-(p-(dimethylamino)phenyl)propenediyl]-p-[((2-tetrahydroquinolinyl)methylene)amino]denzoate , 1981 .
[18] D. Rosson,et al. Essential tyrosyl residues in Lactobacillus casei thymidylate synthetase. , 1980, Biochemical and biophysical research communications.
[19] M. Belfort,et al. A single functional arginyl residue involved in the catalysis promoted by Lactobacillus casei thymidylate synthetase. , 1980, Archives of biochemistry and biophysics.
[20] P. Danenberg,et al. Hydrodynamic behavior of human and bacterial thymidylate synthetases and thymidylate synthetase--5-fluoro-2'-deoxyuridylate--5,10-methylenetetrahydrofolate complexes. Evidence for large conformational changes during catalysis. , 1980, Biochemistry.
[21] Dunlap Rb,et al. Essential arginyl residues in thymidylate synthetase from amethopterin-resistant Lactobacillus casei. , 1979 .
[22] T. Haertlé,et al. Thymidylate synthetase from Escherichia coli K12. Purification, and dependence of kinetic properties on sugar conformation and size of the 2' substituent. , 1979, European journal of biochemistry.
[23] K. Danenberg,et al. Evidence for a sequential interaction of the subunits of thymidylate synthetase. , 1979, The Journal of biological chemistry.
[24] G. Maley,et al. The primary structure of Lactobacillus casei thymidylate synthetase. II. The complete amino acid sequence of the active site peptide, CNBr 4. , 1979, The Journal of biological chemistry.
[25] R. Byrd,et al. Elucidation of the detailed structures of the native and denatured ternary complexes of thymidylate synthetase via fluorine-19 NMR , 1978 .
[26] K. Danenberg,et al. Effect of 5, 10-methylenetetrahydrofolate on the dissociation of 5-fluoro-2'-deoxyuridylate from thymidylate synthetase: evidence for an ordered mechanism. , 1978, Biochemistry.
[27] W. A. Munroe,et al. Kinetics of sulfhydryl group modification of thymidylate synthetase: a proposal for activation of catalytic cysteinly residues. , 1978, Biochemical and biophysical research communications.
[28] F. Maley,et al. Protective effect of the pteroylpolyglutamates and phosphate on the proteolytic inactivation of thymidylate synthetase. , 1977, Archives of biochemistry and biophysics.
[29] Y. Wataya,et al. Thymidylate synthetase: fluorine-19 nmr characterization of the active site peptide covalently bound to 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. , 1976, Biochemical and biophysical research communications.
[30] F. Maley,et al. Demonstration of separate binding sites for the folate coenzymes and deoxynucleotides with inactivated Lactobacillus casei thymidylate synthetase. , 1976, Biochemical and biophysical research communications.
[31] D. Santi,et al. On the structure of the cofactor in the complex formed with thymidylate synthetase, 5,10-methylenetetrahy-drofolate and 5-fluoro-2'-deoxyuridylate. , 1976, Biochimica et biophysica acta.
[32] D. Santi,et al. Thymidylate synthetase: studies on peptide containing covalently bound 5-fluoro-2'-deoxyuridylate and 5,10-methylenetetrahydrofolate. , 1976, Biochemical and biophysical research communications.
[33] J. Lyon,et al. Formation of ternary complexes of thymidylate synthetase as followed by absorbance, fluorescence, and circular dichroic spectra and gel electrophoresis. , 1976, The Journal of biological chemistry.
[34] G. Maley,et al. Factors affecting substrate binding in Lactobacillus casei thymidylate synthetase as studied by equilibrium dialysis. , 1976, Biochemistry.
[35] G. Maley,et al. The effect of substrate analogs on the circular dichroic spectra of thymidylate synthetase from Lactobacillus casei. , 1975, Biochemistry.
[36] R. Sharma,et al. Study of thymidylate synthetase-function by laser Raman spectroscopy. , 1975, Biochimica et biophysica acta.
[37] R. Sharma,et al. Quenching of thymidylate synthetase fluorescence by substrate analogs. , 1975, Biochemical and biophysical research communications.
[38] C. Heidelberger,et al. Structures of reversible and irreversible complexes of thymidylate synthetase and fluorinated pyrimidine nucleotides. , 1974, Biochemistry.
[39] R. B. Dunlap,et al. The carboxypeptidase-dependent inactivation of thymidylate synthetase. , 1974, The Journal of biological chemistry.
[40] D. Santi,et al. Mechanism of interaction of thymidylate synthetase with 5-fluorodeoxyuridylate. , 1974, Biochemistry.
[41] D. Santi,et al. 5-Fluoro-2'-deoxyuridylate: covalent complex with thymidylate synthetase. , 1972, Proceedings of the National Academy of Sciences of the United States of America.
[42] G. Maley,et al. The purification and properties of thymidylate synthetase from chick embryo extracts. , 1967, The Journal of biological chemistry.
[43] W. Jencks,et al. The dissociation constants of tetrahydrofolic acid. , 1966, The Journal of biological chemistry.
[44] Raymond L. Blakley,et al. THE BIOSYNTHESIS OF THYMIDYLIC ACID. V. HYDROGEN ISOTOPE STUDIES WITH DIHYDROFOLIC REDUCTASE AND THYMIDYLATE SYNTHETASE. , 1963, The Journal of biological chemistry.
[45] M. Friedkin,et al. The enzymatic synthesis of thymidylate. II. Transfer of tritium from tetrahydrofolate to the methyl group of thymidylate. , 1962, The Journal of biological chemistry.
[46] D. M. Greenberg,et al. Studies on the conversion of deoxyuridylic acid to thymidylic acid by a soluble extract from rat thymus. , 1958, Archives of biochemistry and biophysics.
[47] A. Jackman,et al. A potent antitumour quinazoline inhibitor of thymidylate synthetase: synthesis, biological properties and therapeutic results in mice. , 1981, European journal of cancer.
[48] S. Benkovic. On the mechanism of action of folate- and biopterin-requiring enzymes. , 1980, Annual review of biochemistry.