Retinal image classification using a histogram based approach

An approach to classifying retinal images using a histogram based representation is described. More specifically, a two stage Case Based Reasoning (CBR) approach is proposed, to be applied to histogram represented retina images to identify Age-related Macular Degeneration (AMD). To measure the similarity between histograms, a time series analysis technique, Dynamic Time Warping (DTW), is employed. The advocated approach utilises two “case bases” for the classification process. The first case base consists of green and saturation histograms with retinal blood vessels removed. The second case base comprises the same histograms, but with the Optic Disc (OD) removed as well. The reported experiments demonstrate that the proposed two stage classification process outperforms the single stage classification process with respect to a number of evaluation metrics: specificity, sensitivity and accuracy.

[1]  Donald J. Berndt,et al.  Using Dynamic Time Warping to Find Patterns in Time Series , 1994, KDD Workshop.

[2]  Aura Conci,et al.  Image mining by content , 2002, Expert Syst. Appl..

[3]  Kung-Sik Chan,et al.  Time Series Analysis: With Applications in R , 2010 .

[4]  M. Goldbaum,et al.  Detection of blood vessels in retinal images using two-dimensional matched filters. , 1989, IEEE transactions on medical imaging.

[5]  Uğur Şevik,et al.  Automatic segmentation of age-related macular degeneration in retinal fundus images , 2008, Comput. Biol. Medicine.

[6]  A. Ramé [Age-related macular degeneration]. , 2006, Revue de l'infirmiere.

[7]  Enrico Grisan,et al.  Luminosity and contrast normalization in retinal images , 2005, Medical Image Anal..

[8]  Huan Liu,et al.  Feature Extraction for Image Mining , 2002, Multimedia Information Systems.

[9]  Eamonn J. Keogh,et al.  Derivative Dynamic Time Warping , 2001, SDM.

[10]  Karel J. Zuiderveld,et al.  Contrast Limited Adaptive Histogram Equalization , 1994, Graphics Gems.

[11]  S. Jain,et al.  Screening for age-related macular degeneration using nonstereo digital fundus photographs , 2006, Eye.

[12]  N. Otsu A threshold selection method from gray level histograms , 1979 .

[13]  Leonidas J. Guibas,et al.  The Earth Mover's Distance as a Metric for Image Retrieval , 2000, International Journal of Computer Vision.

[14]  Aliaa A. A. Youssif,et al.  Optic Disc Detection From Normalized Digital Fundus Images by Means of a Vessels' Direction Matched Filter , 2008, IEEE Transactions on Medical Imaging.

[15]  Zaher Al Aghbari Effective Image Mining by Representing Color Histograms as Time Series , 2009, J. Adv. Comput. Intell. Intell. Informatics.

[16]  Mohd Hanafi Ahmad Hijazia,et al.  A Histogram Approach for the Screening of Age-Related Macular Degeneration , 2009 .

[17]  Roberto Brunelli,et al.  Histograms analysis for image retrieval , 2001, Pattern Recognit..

[18]  I. Deary,et al.  Retinal image analysis: Concepts, applications and potential , 2006, Progress in Retinal and Eye Research.

[19]  L. R. Rabiner,et al.  A comparative study of several dynamic time-warping algorithms for connected-word recognition , 1981, The Bell System Technical Journal.

[20]  Michalis E. Zervakis,et al.  Detection and segmentation of drusen deposits on human retina: Potential in the diagnosis of age-related macular degeneration , 2003, Medical Image Anal..

[21]  Jonathan D. Cryer,et al.  Time Series Analysis , 1986 .

[22]  Janet L. Kolodner,et al.  Case-Based Reasoning , 1989, IJCAI 1989.

[23]  Ahmed S. Fahmy,et al.  Ultrafast Localization of the Optic Disc Using Dimensionality Reduction of the Search Space , 2009, MICCAI.

[24]  Alireza Osareh,et al.  Automated identification of diabetic retinal exudates and the optic disc , 2004 .