Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions
暂无分享,去创建一个
R. D'Hooge | S. Stroobants | B. de Strooper | D. Balschun | P. Saftig | M. Schweizer | M. Glatzel | D. Isbrandt | M. Willem | T. Ahmed | H. Altmeppen | J. Prox | C. Bernreuther | S. Lammich | K. Horré | Jasper Grendel
[1] T. Golde,et al. Genetic Suppression of Transgenic APP Rescues Hypersynchronous Network Activity in a Mouse Model of Alzeimer's Disease , 2014, The Journal of Neuroscience.
[2] R. Tanzi,et al. ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function , 2013, Neuron.
[3] F. Polleux,et al. The CAMKK2-AMPK Kinase Pathway Mediates the Synaptotoxic Effects of Aβ Oligomers through Tau Phosphorylation , 2013, Neuron.
[4] B. Sabatini,et al. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. , 2012, Nature neuroscience.
[5] N. Matsuki,et al. Activity-Dependent Proteolytic Cleavage of Neuroligin-1 , 2012, Neuron.
[6] P. Saftig,et al. Ectodomain shedding and ADAMs in development , 2012, Development.
[7] T. Montine,et al. ADAM10 expression and promoter haplotype in Alzheimer's disease , 2012, Neurobiology of Aging.
[8] P. Hof,et al. Amyloid precursor protein (APP) regulates synaptic structure and function , 2012, Molecular and Cellular Neuroscience.
[9] G. Buzsáki,et al. Mechanisms of gamma oscillations. , 2012, Annual review of neuroscience.
[10] Shao-Jun Tang,et al. Activation of NMDA Receptors Upregulates A Disintegrin and Metalloproteinase 10 via a Wnt/MAPK Signaling Pathway , 2012, The Journal of Neuroscience.
[11] H. Federoff,et al. Ectodomain shedding of nectin‐1 regulates the maintenance of dendritic spine density , 2012, Journal of neurochemistry.
[12] G. Evin,et al. β‐Site APP‐cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis , 2012, Journal of neurochemistry.
[13] B. Allinquant,et al. Functions of Aβ, sAPPα and sAPPβ : similarities and differences , 2012, Journal of neurochemistry.
[14] K. Manova,et al. Deletion of Adam10 in endothelial cells leads to defects in organ-specific vascular structures. , 2011, Blood.
[15] B. de Strooper,et al. Lack of a-disintegrin-and-metalloproteinase ADAM10 leads to intracellular accumulation and loss of shedding of the cellular prion protein in vivo , 2011, Molecular Neurodegeneration.
[16] B. de Strooper,et al. Amyloid precursor protein mutation E682K at the alternative β-secretase cleavage β′-site increases Aβ generation† , 2011, EMBO molecular medicine.
[17] R. Petralia,et al. MAGUKs, Synaptic Development, and Synaptic Plasticity , 2011, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.
[18] M. Dalva,et al. EphB Controls NMDA Receptor Function and Synaptic Targeting in a Subunit-Specific Manner , 2011, The Journal of Neuroscience.
[19] Kristen M Harris,et al. Coordination of size and number of excitatory and inhibitory synapses results in a balanced structural plasticity along mature hippocampal CA1 dendrites during LTP , 2011, Hippocampus.
[20] F. Bussolino,et al. Neurexins and neuroligins: synapses look out of the nervous system , 2011, Cellular and Molecular Life Sciences.
[21] A. Craig,et al. Synaptic organizing complexes , 2011, Current Opinion in Neurobiology.
[22] C. Blobel,et al. The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling , 2011, Development.
[23] Julie Harris,et al. Reversing EphB2 depletion rescues cognitive functions in Alzheimer model , 2011, Nature.
[24] C. Mulle,et al. Synaptic Localization and Activity of ADAM10 Regulate Excitatory Synapses through N-Cadherin Cleavage , 2010, The Journal of Neuroscience.
[25] T. Südhof,et al. Inactivation of presenilins causes pre-synaptic impairment prior to post-synaptic dysfunction , 2010, Journal of neurochemistry.
[26] M. Giustetto,et al. Blocking ADAM10 synaptic trafficking generates a model of sporadic Alzheimer's disease. , 2010, Brain : a journal of neurology.
[27] E. Kremmer,et al. ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons , 2010, The EMBO journal.
[28] P. Saftig,et al. Activity-dependent α-Cleavage of Nectin-1 Is Mediated by A Disintegrin and Metalloprotease 10 (ADAM10)* , 2010, The Journal of Biological Chemistry.
[29] G. Weskamp,et al. The Disintegrin/Metalloproteinase ADAM10 Is Essential for the Establishment of the Brain Cortex , 2010, The Journal of Neuroscience.
[30] F. Fahrenholz,et al. Upregulation of the α‐secretase ADAM10 – risk or reason for hope? , 2010, The FEBS journal.
[31] R. D'Hooge,et al. Vesicular glutamate transporter VGLUT1 has a role in hippocampal long-term potentiation and spatial reversal learning. , 2010, Cerebral cortex.
[32] Roberto Malinow,et al. Amyloid beta from axons and dendrites reduces local spine number and plasticity , 2010, Nature Neuroscience.
[33] Adriano B. L. Tort,et al. Theta–gamma coupling increases during the learning of item–context associations , 2009, Proceedings of the National Academy of Sciences.
[34] T. Südhof,et al. Conditional Forebrain Inactivation of Nicastrin Causes Progressive Memory Impairment and Age-Related Neurodegeneration , 2009, The Journal of Neuroscience.
[35] B. de Strooper,et al. ADAM10, the Rate-limiting Protease of Regulated Intramembrane Proteolysis of Notch and Other Proteins, Is Processed by ADAMS-9, ADAMS-15, and the γ-Secretase* , 2009, Journal of Biological Chemistry.
[36] P. Saftig,et al. The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functions. , 2009, Seminars in cell & developmental biology.
[37] P. Saftig,et al. A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane‐bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10) , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[38] Jyothi Arikkath,et al. Cadherins and catenins at synapses: roles in synaptogenesis and synaptic plasticity , 2008, Trends in Neurosciences.
[39] C. Behl,et al. Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress , 2008, Neuroscience.
[40] P. Rakic,et al. Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus , 2007, Proceedings of the National Academy of Sciences.
[41] M. Korte,et al. The Secreted β-Amyloid Precursor Protein Ectodomain APPsα Is Sufficient to Rescue the Anatomical, Behavioral, and Electrophysiological Abnormalities of APP-Deficient Mice , 2007, The Journal of Neuroscience.
[42] M. Dalva,et al. Cell adhesion molecules: signalling functions at the synapse , 2007, Nature Reviews Neuroscience.
[43] A. Jeromin,et al. Synapse-Associated Protein-97 Mediates α-Secretase ADAM10 Trafficking and Promotes Its Activity , 2007, The Journal of Neuroscience.
[44] M. Korte,et al. The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient mice. , 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[45] A. Jeromin,et al. Synapse-associated protein-97 mediates alpha-secretase ADAM10 trafficking and promotes its activity. , 2007, The Journal of neuroscience : the official journal of the Society for Neuroscience.
[46] F. Fahrenholz,et al. α-Secretase Activation – An Approach to Alzheimer’s Disease Therapy , 2006, Neurodegenerative Diseases.
[47] J. Lieberman,et al. Metalloprotease-induced ectodomain shedding of neural cell adhesion molecule (NCAM). , 2006, Journal of neurobiology.
[48] Lynn Hazan,et al. Klusters, NeuroScope, NDManager: A free software suite for neurophysiological data processing and visualization , 2006, Journal of Neuroscience Methods.
[49] P. Saftig,et al. Regulated ADAM10-dependent Ectodomain Shedding of γ-Protocadherin C3 Modulates Cell-Cell Adhesion* , 2006, Journal of Biological Chemistry.
[50] M. Takeichi,et al. Interneurite affinity is regulated by heterophilic nectin interactions in concert with the cadherin machinery , 2006, The Journal of cell biology.
[51] Masaaki Komatsu,et al. Loss of autophagy in the central nervous system causes neurodegeneration in mice , 2006, Nature.
[52] F. Fahrenholz,et al. Alpha-secretase activation--an approach to Alzheimer's disease therapy. , 2006, Neuro-degenerative diseases.
[53] P. Livrea,et al. Soluble β-Amyloid1-40 Induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses , 2005, The Journal of Neuroscience.
[54] C. Blobel,et al. Adam Meets Eph: An ADAM Substrate Recognition Module Acts as a Molecular Switch for Ephrin Cleavage In trans , 2005, Cell.
[55] C. Blobel,et al. L1 Is Sequentially Processed by Two Differently Activated Metalloproteases and Presenilin/γ-Secretase and Regulates Neural Cell Adhesion, Cell Migration, and Neurite Outgrowth , 2005, Molecular and Cellular Biology.
[56] H. Uno,et al. Deficits in Motor Coordination with Aberrant Cerebellar Development in Mice Lacking Testicular Orphan Nuclear Receptor 4 , 2005, Molecular and Cellular Biology.
[57] B. de Strooper,et al. ADAM10 cleavage of N‐cadherin and regulation of cell–cell adhesion and β‐catenin nuclear signalling , 2005, The EMBO journal.
[58] P. Greengard,et al. Regulation of NMDA receptor trafficking by amyloid-beta. , 2005, Nature neuroscience.
[59] E. Godaux,et al. A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model. , 2004, The Journal of clinical investigation.
[60] E. Kandel,et al. Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration , 2004, Neuron.
[61] Alcino J. Silva,et al. Learning and Memory Deficits in Notch Mutant Mice , 2003, Current Biology.
[62] Tony Hunter,et al. Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration , 2003, Nature.
[63] P. Altevogt,et al. ADAM10‐mediated cleavage of L1 adhesion molecule at the cell surface and in released membrane vesicles , 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[64] G. Buzsáki,et al. Hippocampal network patterns of activity in the mouse , 2003, Neuroscience.
[65] B. de Strooper,et al. The disintegrin/metalloprotease ADAM 10 is essential for Notch signalling but not for alpha-secretase activity in fibroblasts. , 2002, Human molecular genetics.
[66] Y. Takai,et al. Nectin: an adhesion molecule involved in formation of synapses. , 2002, The Journal of cell biology.
[67] G. Buzsáki. Theta Oscillations in the Hippocampus , 2002, Neuron.
[68] B. Strooper,et al. The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein. , 2001, The Journal of biological chemistry.
[69] T. Lemberger,et al. A CamKIIalpha iCre BAC allows brain-specific gene inactivation. , 2001, Genesis.
[70] J G Flanagan,et al. Regulated cleavage of a contact-mediated axon repellent. , 2000, Science.
[71] Anirvan Ghosh,et al. Nuclear Notch1 signaling and the regulation of dendritic development , 2000, Nature Neuroscience.
[72] E. Kojro,et al. Constitutive and regulated alpha-secretase cleavage of Alzheimer's amyloid precursor protein by a disintegrin metalloprotease. , 1999, Proceedings of the National Academy of Sciences of the United States of America.
[73] B. Strooper,et al. Transgenic mice expressing an α-secretion mutant of the amyloid precursor protein in the brain develop a progressive CNS disorder , 1998, Behavioural Brain Research.
[74] B. Strooper,et al. 801 Expression in brain of Amyloid Precursor Protein mutated in the α-secretase site, causes disturbed behavior, neuronal degeneration and premature death in transgenic mice , 1996, Neurobiology of Aging.
[75] H. Eichenbaum,et al. Learning‐related patterns of CA1 spike trains parallel stimulation parameters optimal for inducing hippocampal long‐term potentiation , 1991, Hippocampus.
[76] G. Lynch,et al. Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events. , 1986, Science.