Severe panuveitis in neuro-Behçet’s disease in Malaysia: a case series

Behçet’s disease (BD) is a multisystemic disease that is very rare in Malaysia. About 5% of patients develop central nervous system involvement, termed neuro-Behçet’s. Neuro-Behçet’s is one of the most serious causes of long-term morbidity and mortality. We report two cases of neuro-Behçet’s associated with uveitis (ocular BD) highlighting the clinical presentation, diagnostic measurement, and therapeutic management of these cases.

[1]  D. Bhojwani.  Successful Treatment of Behcet’s Eye Disease with Infliximab Therapy , 2015 .

[2]  A. Silman,et al.  Diagnosis and management of Neuro-Behçet’s disease: international consensus recommendations , 2013, Journal of the Neurological Sciences.

[3]  D. Kidd.  Neurological Complications of Behçet’s Syndrome , 2012, Current Neurology and Neuroscience Reports.

[4]  T. Matsui,et al.  An attack of acute neuro-Behçet’s disease during the course of chronic progressive neuro-Behçet’s disease: report of two cases , 2010, Modern rheumatology.

[5]  D. Kidd,et al.  Neuro-Behçet's disease: epidemiology, clinical characteristics, and management , 2009, The Lancet Neurology.

[6]  J. Kempen,et al.  Ocular inflammation in Behçet disease: incidence of ocular complications and of loss of visual acuity. , 2008, American journal of ophthalmology.

[7]  P Sandroni,et al.  Second consensus statement on the diagnosis of multiple system atrophy , 2008, Neurology.

[8]  S. Hirohata.  Potential New Therapeutic Options for Involvement of Central Nervous System in Behcets Disease (Neuro-Behcets Syndrome) , 2007 .

[9]  N. Scolding,et al.  Neuro‐Behçet's disease in Caucasians: a study of 22 patients , 2007, European journal of neurology.

[10]  M. Houman,et al.  Promising new therapies for Behcet's disease. , 2006, European journal of internal medicine.

[11]  S. Androudi.  Current concepts in the etiology and treatment of Behçet disease. , 2006, Survey of ophthalmology.

[12]  U. Elgin,et al.  Incidence of Secondary Glaucoma in Behçet Disease , 2004, Journal of glaucoma.

[13]  A. Zainal,et al.  Behcet's disease with vascular complications. , 2004, The Medical journal of Malaysia.

[14]  İ. Tuğal-Tutkun,et al.  Uveitis in Behçet disease: an analysis of 880 patients. , 2004, American journal of ophthalmology.

[15]  S. Saip,et al.  Behçet's syndrome and the nervous system , 2004, Current opinion in neurology.

[16]  K. Sharquie,et al.  Prevalence and patterns of neurological involvement in Behcet’s disease: a prospective study from Iraq , 2003, Journal of neurology, neurosurgery, and psychiatry.

[17]  H. Ben Maïz,et al.  [Neurological manifestations in Behcet's disease. Forty observations in a cohort of 300 patients]. , 2002, Journal des maladies vasculaires.

[18]  S. Abdelhak,et al.  [Neurologic manifestations of Behcet's disease: analysis of a series of 27 patients]. , 2002, La Revue de medecine interne.

[19]  V. Kaklamani,et al.  Treatment of Behçet's disease--an update. , 2001, Seminars in arthritis and rheumatism.

[20]  N. Kocer,et al.  Behçet's disease: diagnostic and prognostic aspects of neurological involvement , 2001, Journal of Neurology.

[21]  O. Ozcebe,et al.  Behçet's disease. , 2019, The New England journal of medicine.

[22]  G. Akman-Demir,et al.  Clinical patterns of neurological involvement in Behçet's disease: evaluation of 200 patients. The Neuro-Behçet Study Group. , 1999, Brain : a journal of neurology.

[23]  S. Ohno,et al.  Behçet's disease, the Silk Road and HLA-B51: historical and geographical perspectives. , 1999, Tissue antigens.

[24]  O. Çoban,et al.  Masked assessment of MRI findings: is it possible to differentiate neuro-Behçet's disease from other central nervous system , 1999, Neuroradiology.

[25]  A. Gürler,et al.  Clinical manifestations of Behçet's disease: an analysis of 2147 patients. , 1997, Yonsei medical journal.

[26]  R. Nussenblatt,et al.  Ocular immunopathology of Behçet's disease. , 1997, Survey of ophthalmology.

[27]  A. Malaviya,et al.  Behçet's disease in India: a clinical, immunological, immunogenetic and outcome study. , 1995, British journal of rheumatology.

[28]  M. Banna,et al.  Neurologic involvement in Behçet disease: imaging findings in 16 patients. , 1991, AJNR. American journal of neuroradiology.

[29]  S. Bahar,et al.  Neurologic involvement in Behçet's syndrome. A prospective study. , 1989, Archives of neurology.

[30]  J. Calabro,et al.  Behcet's Disease: A Contemporary Synopsis , 1988 .

[31]  G. Ehrlich,et al.  Behçet disease (Behçet syndrome). , 1979, Seminars in arthritis and rheumatism.

[32]  M. Youssef,et al.  Neuro-Behçet's syndrome in the United Arab Republic. , 1973, European neurology.

[33]  F. C. Winter,et al.  The ocular pathology of Behçet's disease. , 1966, American journal of ophthalmology.