LACK OF RESPONSE OF 1,25‐DIHYDROXYCHOLECALCIFEROL TO EXOGENOUS PARATHYROID HORMONE IN A PATIENT WITH TREATED PSEUDOHYPOPARATHYROIDISM

The response of serum 1,25‐dihydroxycholecalciferol (1,25‐OH2CC) concentration to the administration of parathyroid extract (PTE) was studied in a patient with pseudohypoparathyroidism (PHP) type I, 3 days after withdrawal of dihydrotachysterol (DHT) treatment. The patient had had a normal serum calcium (Ca), phosphorus (P) and immunoreactive parathyroid hormone (iPTH) level on DHT for 6 years. After PTE administration no rise of the 1,25‐OH2CC concentration and no response of urinary cAMP and P were seen.

[1]  T. Visser,et al.  SERUM CONCENTRATIONS OF METABOLITES OF VITAMIN D IN PATIENTS WITH CHRONIC RENAL FAILURE (CRF). CONSEQUENCES FOR THE TREATMENT WITH 1‐α‐HYDROXY‐DERIVATIVES , 1981, Clinical endocrinology.

[2]  A. Moses,et al.  Studies on the attainment of normocalcemia in patients with pseudohypoparathyroidism. , 1980, The American journal of medicine.

[3]  R. Mason,et al.  Parathyroid hormone effect on 1,25-dihydroxyvitamin D in hypoparathyroidism. , 1980, Annals of internal medicine.

[4]  J. Eisman,et al.  MODULATION OF PLASMA 1,25-DIHYDROXYVITAMIN D IN MAN BY STIMULATION AND SUPPRESSION TESTS , 1979, The Lancet.

[5]  J. Zerwekh,et al.  A patient with pseudohypoparathyroidism with increased serum calcium and 1 alpha, 25-dihydroxyvitamin D after exogenous parathyroid hormone administration. , 1979, Journal of Clinical Endocrinology and Metabolism.

[6]  J. Lemann,et al.  The effects of dihydrotachysterol therapy on the measurement of plasma 1,25-(OH)2-vitamin D in humans. , 1979, The Journal of laboratory and clinical medicine.

[7]  M. Haussler,et al.  Selective deficiency of 1,25-dihydroxycholecalciferol. A cause of isolated skeletal resistance to parathyroid hormone. , 1977, The New England journal of medicine.

[8]  M. Golabi,et al.  Hypo-hyperparathyroidism: evidence for a defective parathyroid hormone. , 1977, Pediatrics.

[9]  A. Moses,et al.  Renal responses to PTH in patients with hormone-resistant (pseudo) hypoparathyroidism. , 1976, The American journal of medicine.

[10]  M. Haussler,et al.  1,25-Dihydroxycholecalciferol deficiency: the probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. , 1976, The Journal of clinical endocrinology and metabolism.

[11]  J. Fischer,et al.  Pseudohypoparathyroidism: Disappearance of the resistance to parathyroid extract during treatment with vitamin D , 1975 .

[12]  H. Lebovitz,et al.  Pseudohypoparathyroidism type II: a possible defect in the reception of the cyclic AMP signal. , 1973, The New England journal of medicine.

[13]  F. Roelfsema,et al.  Calcium and Phosphorus Metabolism, Parathyroid Hormone, Calcitonin and Bone Histology in Pseudohypoparathyroidism * , 1973, European journal of clinical investigation.

[14]  K. M. McDonald Responsiveness of bone to parathyroid extract in siblings with pseudohypoparathyroidism. , 1972, Metabolism: clinical and experimental.

[15]  B. Brown,et al.  A simple and sensitive saturation assay method for the measurement of adenosine 3':5'-cyclic monophosphate. , 1971, The Biochemical journal.

[16]  D. Fraser,et al.  Pseudohypoparathyroidism: responsiveness to parathyroid extract induced by vitamin D2 therapy. , 1970, The Journal of clinical endocrinology and metabolism.

[17]  R. Lequin,et al.  A RADIOIMMUNOASSAY FOR PARATHYROID HORMONE IN MAN , 1969 .

[18]  Roger DeMordaunt,et al.  Hypoparathyroidism , 1963 .

[19]  P. Stern,et al.  Effects of 1,25-dihydroxyvitamin D3 on calcium metabolism and quantitative bone histology in pseudohypoparathyroidism , 1978 .

[20]  R. Buckle Radioimmunoassay of parathyroid hormone in man. , 1972, The Journal of endocrinology.