D1 and D2Dopamine Receptors in Perinatal and Adult Basal Ganglia

There is reason to believe that dopamine is important in developmental programs of the basal ganglia, brain nuclei implicated in motor and cognitive processing. Dopamine exerts effects through dopamine receptors, which are predominantly of the D1 and D2 subtypes in the basal ganglia. Cocaine acts as a stimulant of dopamine receptors and may cause long-term abnormalities in children exposed in utero. Dopamine receptor(primarily D1) stimulation has been linked to gene regulation. Therefore, D1 and D2 receptor densities in perinatal and adult striatum and globus pallidus were examined using quantitative autoradiography. The most striking finding was that pallidal D1 receptor densities were 7-15 times greater in the perinatal cases than in the adult. Pallidal D2 receptor densities were similar at both ages. In both the adult and perinatal striatum, D2 receptor densities were greater in the putamen than in the caudate, and both D1 and D2 receptor densities were modestly enriched in caudate striosomes compared with the matrix. In both caudate and putamen, perinatal D1 receptor levels were within the adult range, whereas D2 receptor levels were only 50% of adult values. The development of D1 and D2 receptors appears to vary across the major subdivisions of the human basal ganglia. The facts that we found such extremely high levels of D1 receptors in the perinatal pallidum, and that D1 receptor activation influences gene regulation, suggest that the globus pallidus could be particularly susceptible to long-term changes with perinatal exposure to cocaine and other D1 receptor agonists or antagonists.

[1]  P. Sokoloff,et al.  Novel dopamine receptors half a decade later. , 1995, Trends in pharmacological sciences.

[2]  S. Hyman,et al.  Postnatal age defines specificity of immediate early gene induction by cocaine in developing rat brain , 1995, The Journal of comparative neurology.

[3]  G. Hanson,et al.  Effect of neonatal hypoxia-ischemia on nigro-striatal dopamine receptors and on striatal neuropeptide Y, dynorphin A and substance P concentrations in rats. , 1994, Brain research. Developmental brain research.

[4]  R B Innis,et al.  Postmortem Stability of Monoamines, Their Metabolites, and Receptor Binding in Rat Brain Regibns , 1994, Journal of Neurochemistry.

[5]  R. Mailman,et al.  Postmortem stability of dopamine D1 receptor mRNA and D1 receptors. , 1993, Brain research. Molecular brain research.

[6]  P. Sastry,et al.  Dopamine receptors in human foetal brains: Characterization, regulation and ontogeny of [3H]spiperone binding sites in striatum , 1992, Neurochemistry International.

[7]  F. Filloux,et al.  Effects of Hypoxic-Ischemic Brain Damage on Dopaminergic Markers in the Neonatal Rat: A Regional Autoradiographic Analysis , 1992, Journal of child neurology.

[8]  I. Chasnoff,et al.  Cocaine/polydrug use in pregnancy: two-year follow-up. , 1992, Pediatrics.

[9]  A. Graybiel,et al.  Expression of the Immediate Early Gene c-fos in Basal Ganglia: Induction by Dopaminergic Drugs , 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

[10]  P. Molinoff,et al.  Ontogeny of dopamine D1 and D2 receptor subtypes in rat basal ganglia: a quantitative autoradiographic study. , 1991, Brain research. Developmental brain research.

[11]  K. Neve,et al.  Characterization and distribution of [125I]epidepride binding to dopamine D2 receptors in basal ganglia and cortex of human brain. , 1991, The Journal of pharmacology and experimental therapeutics.

[12]  A. Levey,et al.  D1 and D2 dopamine receptor mRNA in rat brain. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[13]  M. Iadarola,et al.  Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[14]  J. Aceves,et al.  Activation of D1 dopamine receptors stimulates the release of GABA in the basal ganglia of the rat , 1990, Neuroscience Letters.

[15]  H. Happe,et al.  Tritium quench in autoradiography during postnatal development of rat forebrain , 1990, Brain Research.

[16]  J. Penney,et al.  The functional anatomy of basal ganglia disorders , 1989, Trends in Neurosciences.

[17]  J. Palacios,et al.  Dopamine receptors in human brain: Autoradiographic distribution of D2 sites , 1989, Neuroscience.

[18]  J. Palacios,et al.  Dopamine receptors in human brain: Autoradiographic distribution of D1 sites , 1989, Neuroscience.

[19]  J. Coyle,et al.  Compartment‐specific changes in the density of choline and dopamine uptake sites and muscarinic and dopaminergic receptors during the development of the baboon striatum: A quantitative receptor autoradiographic study , 1989, The Journal of comparative neurology.

[20]  W. Zeng,et al.  Dopamine D1 receptor development in the rat striatum: early localization in striosomes , 1989, Brain Research.

[21]  A. Graybiel,et al.  [3H]SCH 23390 binding to D1 dopamine receptors in the basal ganglia of the cat and primate: Delineation of striosomal compartments and pallidal and nigral subdivisions , 1988, Neuroscience.

[22]  M. Johnston,et al.  Glutamate recognition sites in human fetal brain , 1988, Neuroscience Letters.

[23]  S. Dixon,et al.  Perinatal cocaine and methamphetamine exposure: Maternal and neonatal correlates , 1987 .

[24]  T. Chase,et al.  D-1 dopamine receptor changes after striatal quinolinic acid lesion. , 1987, European journal of pharmacology.

[25]  B. Brody,et al.  Sequence of Central Nervous System Myelination in Human Infancy. I. An Autopsy Study of Myelination , 1987, Journal of neuropathology and experimental neurology.

[26]  P. Molinoff,et al.  Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[27]  J. Marshall,et al.  Human striatal dopamine receptors are organized in compartments. , 1986, Proceedings of the National Academy of Sciences of the United States of America.

[28]  B. Scatton,et al.  Autoradiographic localization and quantification of dopamine D2 receptors in normal human brain with [3H]N-n-propylnorapomorphine , 1986, Brain Research.

[29]  G. Vauquelin,et al.  Regional distribution of the dopamine D2 receptors in the mesotelencephalic dopamine neuron system of human brain , 1985, Journal of the Neurological Sciences.

[30]  M. Adinolfi,et al.  THE DEVELOPMENT OF THE HUMAN BLOOD‐CSF‐BRAIN BARRIER , 1985, Developmental medicine and child neurology.

[31]  H. Yeung,et al.  Ginseng saponin treatment does not alter brain or pituitary levels of beta-endorphin and dynorphin. , 1985, Biochemical pharmacology.

[32]  C. Ho,et al.  Opiate receptor binding profile in the rabbit cerebellum and brain membranes. , 1985, Biochemical pharmacology.

[33]  G. Breese,et al.  Neonatal-6-hydroxydopamine treatment: Model of susceptibility for self-mutilation in the lesch-nyhan syndrome , 1984, Pharmacology Biochemistry and Behavior.

[34]  S. Iversen,et al.  Sensorimotor impairments following localized kainic acid and 6-hydroxydopamine lesions of the neostriatum , 1982, Brain Research.

[35]  Allen Mh,et al.  Cocaine and alcohol use in pregnancy. , 1994 .

[36]  D. Sibley,et al.  Molecular biology of dopamine receptors. , 1992, Trends in pharmacological sciences.

[37]  C. Gerfen.  The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. , 1992, Annual review of neuroscience.

[38]  A. Parent,et al.  The dopaminergic nigropallidal projection in primates: distinct cellular origin and relative sparing in MPTP-treated monkeys. , 1990, Advances in neurology.

[39]  J. Lauder,et al.  Neurotransmitters as morphogens. , 1988, Progress in brain research.

[40]  Philip Seeman,et al.  Human brain dopamine receptors in children and aging adults , 1987, Synapse.