Dynamical effects of calcium‐sensitive potassium currents on voltage and calcium alternans

A mathematical model of a small conductance Ca2+‐activated potassium (SK) channel was developed and incorporated into a physiologically detailed ventricular myocyte model. Ca2+‐sensitive K+ currents promote negative intracellular Ca2+ to membrane voltage (CAi2+→ Vm) coupling. Increase of Ca2+‐sensitive K+ currents can be responsible for electromechanically discordant alternans and quasiperiodic oscillations at the cellular level. At the tissue level, Turing‐type instability can occur when Ca2+‐sensitive K+ currents are increased.

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