Group B Streptococcus bacteremia elicits beta C protein-specific IgMand IgG in humans.

Group B Streptococcus (GBS) beta C protein elicits protective antibodies in experimental animals, making beta C protein an attractive component of a human GBS glycoconjugate vaccine. We determined whether natural exposure to beta C protein elicits antibodies in humans. Geometric mean concentrations (in micrograms per milliliter) of beta C-specific immunoglobulin (Ig) M and IgG as determined by enzyme-linked immunosorbent assay were similar in serum from 16 colonized (0.82 and 0.76, respectively) and 48 age-matched noncolonized (0.96 and 0.74, respectively) pregnant women. Serum from 3 women with beta C GBS bacteremia had significantly higher levels of IgM (6.0) and IgG (52.9) (P=.01 and 0.01, respectively). Invasive disease but not colonization elicits beta C-specific IgM and IgG.

[1]  M. Weinstein,et al.  The projected health benefits of maternal group B streptococcal vaccination in the era of chemoprophylaxis. , 2005, Vaccine.

[2]  G. Lindahl,et al.  Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens , 2005, Clinical Microbiology Reviews.

[3]  C. Baker,et al.  Immunization of pregnant women with group B streptococcal type III capsular polysaccharide-tetanus toxoid conjugate vaccine. , 2003, Vaccine.

[4]  L. Madoff,et al.  Vaccines to prevent neonatal GBS infection. , 2002, Seminars in neonatology : SN.

[5]  D. Kasper,et al.  Quantitative determination of immunoglobulin G specific for group B streptococcal beta C protein in human maternal serum. , 2002, The Journal of infectious diseases.

[6]  C. Adair,et al.  Antibodies to capsular polysaccharides of group B Streptococcus in pregnant Canadian women: relationship to colonization status and infection in the neonate. , 2001, The Journal of infectious diseases.

[7]  M. Krohn,et al.  Group B Streptococcal Colonization and Serotype‐Specific Immunity in Pregnant Women at Delivery , 2000, Obstetrics and gynecology.

[8]  C. Leclerc,et al.  Reduced Response to Multiple Vaccines Sharing Common Protein Epitopes That Are Administered Simultaneously to Infants , 1998, Infection and Immunity.

[9]  A. Schuchat,et al.  Serotype distribution of invasive group B streptococcal isolates in Maryland: implications for vaccine formulation. Maryland Emerging Infections Program. , 1998, The Journal of infectious diseases.

[10]  D. Kasper,et al.  Immune response to type III group B streptococcal polysaccharide-tetanus toxoid conjugate vaccine. , 1996, The Journal of clinical investigation.

[11]  D. Kasper,et al.  Maternal immunization of mice with group B streptococcal type III polysaccharide-beta C protein conjugate elicits protective antibody to multiple serotypes. , 1994, The Journal of clinical investigation.

[12]  D. Kasper,et al.  Protection of neonatal mice from group B streptococcal infection by maternal immunization with beta C protein , 1992, Infection and immunity.

[13]  F. Ausubel,et al.  Cloned alpha and beta C-protein antigens of group B streptococci elicit protective immunity , 1991, Infection and immunity.

[14]  L. Bevanger,et al.  Mouse-protective antibodies against the Ibc proteins of group B streptococci. , 2009, Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology.

[15]  Dwight R. Johnson,et al.  Group B streptococcal Ibc protein antigen: distribution of two determinants in wild-type strains of common serotypes , 1984, Journal of clinical microbiology.

[16]  D. Kasper,et al.  Role of antibody to native type III polysaccharide of group B Streptococcus in infant infection. , 1981, Pediatrics.

[17]  D. Kasper,et al.  Correlation of maternal antibody deficiency with susceptibility to neonatal group B streptococcal infection. , 1976, The New England journal of medicine.

[18]  M. Mccarty,et al.  Multiple mouse-protective antibodies directed against group B streptococci. Special reference to antibodies effective against protein antigens , 1975, The Journal of experimental medicine.