A generic sensor for ultra low analyte concentration detection

This paper reports on the development of a MEMS based generic mass sensor system (international patents pending) aimed at quantitative analyte measurement with a sensitivity of the order of 0.01 ng cm -2 . The sensor utilizes the property of cyclic symmetry to auto-compensate for any system drifts due to temperature fluctuations. Initial characterization of the sensor has demonstrated this autocompensation mechanism. Immobilization protocols are currently being established using antibody immobilization onto a gold surface. The drive / sense electronics for the sensor system are under development.