Long -an dShort-Ter mEffect so fBiologica lHydrogel so nCapsule Microvascula rDensit yaroun dImplant si nRats

Fibrou scapsul eformatio naroun dimplant sca ninhibi tsolut eexchang ebetween implantabl edevice san dth ecirculation .Parylene- ncoate dpolycarbonat edisk ssurrounded wit hgrowt hfacto rreduce dMatrigel t(MG )o rsevera lgelatin-base dmatrice swer eimplanted intramuscularl yint orat sfo r2 1o r5 0days .M Gsupplemente dwit hvascula rendothelial growt hfacto r(VEGF )o rbasi cfibroblas tgrowt hfacto r(bFGF )increase dcapsul emicrovas- cula rdensit ya t2 1day s( p <0.05 )whe ncompare dt obar eparylene-coate dpolycarbonate disk s(control) .Th eincrease dmicrovascula rdensit yaroun dVEGF -an dbFGF-treate dim- plant sregresse db y5 0day san dwa sn olonge rsignificantl ydifferen tfro mcontrols .The microvascula rdensit yinduce db yth egelatin-base dmatrice swa sno tsignificantl ydifferent fro mcontrol sa t2 1days ,bu twa sincrease da t5 0day s( p <0.05) ,suggestin ga slower, long-ter meffect .Disk streate dwit hM Gan dgelatin-base dmatrice sha dthinne rcapsule sa t21 day s( p <0.05) .B y5 0days ,th ecapsul ethicknesse saroun dthes eimplant swer en olonger statisticall ythinne rtha ncontrols .Th ecapsul ethicknes saroun dimplant streate dwit hVEGF, bFGF ,an dessentia lgelatin-base dmatri xwa sthinne rtha ncontrol sa t5 0day s( p <0.05). Thes eresult sindicat etha ti ti spossibl et oincreas efunctiona lmicrovascula rdensit ywithin fibrou scapsule susin gangiogeni cgrowt hfactor san dgelatin-base dmatrices .However ,this effec tma yb eshort-lived ,requirin gchroni cadministratio no fgrowt hfactors . © 200 1Joh nWiley

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