Susceptibility of Nrf2-Null Mice to Steatohepatitis and Cirrhosis upon Consumption of a High-Fat Diet Is Associated with Oxidative Stress, Perturbation of the Unfolded Protein Response, and Disturbance in the Expression of Metabolic Enzymes but Not with Insulin Resistance
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J. Hayes | S. Chowdhry | A. Dinkova-Kostova | S. Walsh | J. Dillon | R. McCrimmon | P. Meakin | F. Ashford | M. Ashford | Ritu S. Sharma
[1] R. Kaufman,et al. Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. , 2014, Antioxidants & redox signaling.
[2] X. Wang,et al. Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis , 2014, Cell Death and Differentiation.
[3] F. Bellanti,et al. Free radical biology for medicine: learning from nonalcoholic fatty liver disease. , 2013, Free radical biology & medicine.
[4] D. Rutkowski,et al. The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis , 2013, PLoS genetics.
[5] Wen Hou,et al. Emerging Role of High-Mobility Group Box 1 (HMGB1) in Liver Diseases , 2013, Molecular Medicine.
[6] Yanhua Zhang,et al. Nrf2 deletion causes “benign” simple steatosis to develop into nonalcoholic steatohepatitis in mice fed a high-fat diet , 2013, Lipids in Health and Disease.
[7] Masayuki Yamamoto,et al. Keap1 knockdown increases markers of metabolic syndrome after long-term high fat diet feeding. , 2013, Free radical biology & medicine.
[8] Hye-Youn Cho. Genomic Structure and Variation of Nuclear Factor (Erythroid-Derived 2)-Like 2 , 2013, Oxidative medicine and cellular longevity.
[9] J. G. Kenna,et al. The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613. , 2013, Antioxidants & redox signaling.
[10] J. Iredale,et al. Extracellular matrix degradation in liver fibrosis: Biochemistry and regulation. , 2013, Biochimica et biophysica acta.
[11] Takafumi Suzuki,et al. Toward clinical application of the Keap1-Nrf2 pathway. , 2013, Trends in pharmacological sciences.
[12] M. Lotze,et al. HMGB1 in Cancer: Good, Bad, or Both? , 2013, Clinical Cancer Research.
[13] A. Sugawara,et al. The Keap1-Nrf2 System Prevents Onset of Diabetes Mellitus , 2013, Molecular and Cellular Biology.
[14] Masayuki Yamamoto,et al. Deletion of Nrf2 leads to rapid progression of steatohepatitis in mice fed atherogenic plus high-fat diet , 2013, Journal of Gastroenterology.
[15] D. Chartoumpekis,et al. Hepatic Gene Expression Profiling in Nrf2 Knockout Mice after Long-Term High-Fat Diet-Induced Obesity , 2013, Oxidative medicine and cellular longevity.
[16] D. Rutkowski,et al. C/EBP Homologous Protein (CHOP) Contributes to Suppression of Metabolic Genes during Endoplasmic Reticulum Stress in the Liver* , 2012, The Journal of Biological Chemistry.
[17] Ajay C Donepudi,et al. Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice , 2012, Diabetes.
[18] T. Ikeda,et al. Dysregulated expression of fatty acid oxidation enzymes and iron‐regulatory genes in livers of Nrf2‐null mice , 2012, Journal of gastroenterology and hepatology.
[19] Jie Liu,et al. Nrf2 deficiency improves glucose tolerance in mice fed a high-fat diet. , 2012, Toxicology and applied pharmacology.
[20] F. Foufelle,et al. New insights into ER stress-induced insulin resistance , 2012, Trends in Endocrinology & Metabolism.
[21] L. Gan,et al. NASH is an Inflammatory Disorder: Pathogenic, Prognostic and Therapeutic Implications , 2012, Gut and liver.
[22] Guido Gerken,et al. The interaction of hepatic lipid and glucose metabolism in liver diseases. , 2012, Journal of hepatology.
[23] T. Mariani,et al. Conditional deletion of Nrf2 in airway epithelium exacerbates acute lung injury and impairs the resolution of inflammation. , 2011, American journal of respiratory cell and molecular biology.
[24] C. Klaassen,et al. Beneficial role of Nrf2 in regulating NADPH generation and consumption. , 2011, Toxicological sciences : an official journal of the Society of Toxicology.
[25] A. Papavassiliou,et al. Nrf2 Represses FGF21 During Long-Term High-Fat Diet–Induced Obesity in Mice , 2011, Diabetes.
[26] Won Dong Kim,et al. Nrf2 inhibits LXRα-dependent hepatic lipogenesis by competing with FXR for acetylase binding. , 2011, Antioxidants & redox signaling.
[27] J. Speakman,et al. Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice , 2011, The Biochemical journal.
[28] Jonathan C. Cohen,et al. Human Fatty Liver Disease: Old Questions and New Insights , 2011, Science.
[29] I. G. Fantus,et al. Oltipraz upregulates the nuclear respiratory factor 2 alpha subunit (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice , 2011, Diabetologia.
[30] Lee H. Dicker,et al. Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity , 2011, Nature.
[31] B. Neuschwander‐Tetri,et al. Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings , 2011, Hepatology.
[32] I. G. Fantus,et al. Erratum to: Oltipraz upregulates the nuclear factor (erythroid-derived 2)-like 2 (NRF2) antioxidant system and prevents insulin resistance and obesity induced by a high-fat diet in C57BL/6J mice , 2011, Diabetologia.
[33] Jiansheng Huang,et al. Transcription factor Nrf2 regulates SHP and lipogenic gene expression in hepatic lipid metabolism. , 2010, American journal of physiology. Gastrointestinal and liver physiology.
[34] M. McMahon,et al. Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals , 2010, Proceedings of the National Academy of Sciences.
[35] M. McMahon,et al. Cancer chemoprevention mechanisms mediated through the Keap1-Nrf2 pathway. , 2010, Antioxidants & redox signaling.
[36] B. Viollet,et al. Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state. , 2010, The Journal of clinical investigation.
[37] Masayuki Yamamoto,et al. Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver , 2010, Journal of proteomics.
[38] C. Klaassen,et al. Enhanced expression of Nrf2 in mice attenuates the fatty liver produced by a methionine- and choline-deficient diet. , 2010, Toxicology and applied pharmacology.
[39] F. Ross,et al. Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010, Cell metabolism.
[40] J. Ntambi,et al. Genetic control of de novo lipogenesis: role in diet-induced obesity , 2010, Critical reviews in biochemistry and molecular biology.
[41] I. Hyodo,et al. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice. , 2010, American journal of physiology. Gastrointestinal and liver physiology.
[42] J. Hayes,et al. Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. , 2010, Free radical biology & medicine.
[43] O. Sansom,et al. Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi , 2009, Proceedings of the National Academy of Sciences.
[44] A. Hevener,et al. AMPK β1 Deletion Reduces Appetite, Preventing Obesity and Hepatic Insulin Resistance* , 2009, The Journal of Biological Chemistry.
[45] M. Sporn,et al. Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide. , 2009, European journal of pharmacology.
[46] Atsushi Fukushima,et al. Reactive oxygen species enhance insulin sensitivity. , 2009, Cell metabolism.
[47] D. Scheuner,et al. Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. , 2009, Cell metabolism.
[48] Michael O. Kelleher,et al. Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents. , 2009, Toxicology and applied pharmacology.
[49] M. Sporn,et al. Genetic versus chemoprotective activation of Nrf2 signaling: overlapping yet distinct gene expression profiles between Keap1 knockout and triterpenoid-treated mice. , 2009, Carcinogenesis.
[50] S. Luquet,et al. GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. , 2009, The Journal of clinical investigation.
[51] M. Katze,et al. UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators. , 2008, Developmental cell.
[52] R. Kaufman,et al. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion , 2008, Proceedings of the National Academy of Sciences.
[53] Masayuki Yamamoto,et al. The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds , 2008, Molecular and Cellular Biology.
[54] Randal J. Kaufman,et al. From endoplasmic-reticulum stress to the inflammatory response , 2008, Nature.
[55] L. Glimcher,et al. Regulation of Hepatic Lipogenesis by the Transcription Factor XBP1 , 2008, Science.
[56] D. Ron,et al. Dephosphorylation of translation initiation factor 2alpha enhances glucose tolerance and attenuates hepatosteatosis in mice. , 2008, Cell metabolism.
[57] M. Diez,et al. Liver lipid metabolism. , 2008, Journal of animal physiology and animal nutrition.
[58] C. Klaassen,et al. NF-E2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet , 2008, Journal of Pharmacology and Experimental Therapeutics.
[59] S. Mantena,et al. Mitochondrial dysfunction and oxidative stress in the pathogenesis of alcohol- and obesity-induced fatty liver diseases. , 2008, Free radical biology & medicine.
[60] R. Eckel,et al. CCAAT/Enhancer-binding Protein β Deletion Reduces Adiposity, Hepatic Steatosis, and Diabetes in Leprdb/db Mice* , 2007, Journal of Biological Chemistry.
[61] U. Meyer,et al. In the regulation of cytochrome P450 genes, phenobarbital targets LKB1 for necessary activation of AMP-activated protein kinase , 2007, Proceedings of the National Academy of Sciences.
[62] Shyam Biswal,et al. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. , 2007, Annual review of pharmacology and toxicology.
[63] B. Staels,et al. The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[64] Mark Hannink,et al. Keap1 Is a Redox-Regulated Substrate Adaptor Protein for a Cul3-Dependent Ubiquitin Ligase Complex , 2004, Molecular and Cellular Biology.
[65] L. Glimcher,et al. Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes , 2004, Science.
[66] Masayuki Yamamoto,et al. Oxidative Stress Sensor Keap1 Functions as an Adaptor for Cul3-Based E3 Ligase To Regulate Proteasomal Degradation of Nrf2 , 2004, Molecular and Cellular Biology.
[67] J. Horton,et al. Molecular mediators of hepatic steatosis and liver injury. , 2004, The Journal of clinical investigation.
[68] J. Alan Diehl,et al. PERK-dependent Activation of Nrf2 Contributes to Redox Homeostasis and Cell Survival following Endoplasmic Reticulum Stress* , 2004, Journal of Biological Chemistry.
[69] K. Itoh,et al. Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence. , 2003, The Biochemical journal.
[70] K. Itoh,et al. Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression* , 2003, Journal of Biological Chemistry.
[71] C. Wolf,et al. Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice. , 2002, The Biochemical journal.
[72] J. Hayes,et al. Chemoprevention of aflatoxin B1 hepatocarcinogenesis by coumarin, a natural benzopyrone that is a potent inducer of aflatoxin B1-aldehyde reductase, the glutathione S-transferase A5 and P1 subunits, and NAD(P)H:quinone oxidoreductase in rat liver. , 2000, Cancer research.
[73] D. Hardie,et al. AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. , 1999, American journal of physiology. Endocrinology and metabolism.
[74] C. Day,et al. Steatohepatitis: a tale of two "hits"? , 1998, Gastroenterology.
[75] K. Itoh,et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements. , 1997, Biochemical and biophysical research communications.
[76] H. Gilbert,et al. Oxidative inactivation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and subunit cross-linking involve different dithiol/disulfide centers. , 1993, The Journal of biological chemistry.
[77] A. Sanyal,et al. Lipotoxicity in NASH. , 2012, Journal of hepatology.
[78] C. Palmeira,et al. Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis. , 2012, Free radical biology & medicine.
[79] Ze Zheng,et al. Measurement of ER stress response and inflammation in the mouse model of nonalcoholic fatty liver disease. , 2011, Methods in enzymology.
[80] T. Tiganis. Reactive oxygen species and insulin resistance: the good, the bad and the ugly. , 2011, Trends in pharmacological sciences.
[81] 杉本 浩一. Deletion of nuclear factor-E2-related factor-2 leads to rapid onset and progression of nutritional steatohepatitis in mice , 2011 .
[82] F. Ross,et al. Use of Cells Expressing gamma Subunit Variants to Identify Diverse Mechanisms of AMPK Activation , 2010 .
[83] S. Rensen,et al. Gastrointestinal , Hepatobiliary and Pancreatic Pathology Increased Hepatic Myeloperoxidase Activity in Obese Subjects with Nonalcoholic Steatohepatitis , 2009 .
[84] C. Klaassen,et al. NF-E 2-Related Factor 2 Inhibits Lipid Accumulation and Oxidative Stress in Mice Fed a High-Fat Diet , 2008 .
[85] G. Farrell,et al. LIVER FAILURE AND LIVER DISEASE Nonalcoholic Fatty Liver Disease: From Steatosis to Cirrhosis , 2006 .
[86] P. Coates,et al. Detecting and quantifying apoptosis in tissue sections. , 2004, Methods in molecular biology.