Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K—mTOR pathway in pancreatic adenocarcinoma

[1]  H. Lane,et al.  Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells , 2009, Proceedings of the National Academy of Sciences.

[2]  Kwok-Kin Wong,et al.  Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition , 2009, Proceedings of the National Academy of Sciences.

[3]  Kevin Curran,et al.  Biochemical, cellular, and in vivo activity of novel ATP-competitive and selective inhibitors of the mammalian target of rapamycin. , 2009, Cancer research.

[4]  C. Sawyers.  Finding and Drugging the Vulnerabilities of RAS-Dependent Cancers , 2009, Cell.

[5]  C. Chresta,et al.  Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR) , 2009, The Biochemical journal.

[6]  A. Kimchi,et al.  Life and death partners: apoptosis, autophagy and the cross-talk between them , 2009, Cell Death and Differentiation.

[7]  D. Hedley,et al.  Activity of a novel, dual PI3-kinase/mTor inhibitor NVP-BEZ235 against primary human pancreatic cancers grown as orthotopic xenografts , 2009, British Journal of Cancer.

[8]  Robbie Loewith,et al.  Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2 , 2009, PLoS biology.

[9]  Laura M. Heiser,et al.  Basal subtype and MAPK/ERK kinase (MEK)-phosphoinositide 3-kinase feedback signaling determine susceptibility of breast cancer cells to MEK inhibition. , 2009, Cancer research.

[10]  David P. Davis,et al.  Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents , 2008, The Journal of cell biology.

[11]  Philippe P Roux,et al.  Oncogenic MAPK Signaling Stimulates mTORC1 Activity by Promoting RSK-Mediated Raptor Phosphorylation , 2008, Current Biology.

[12]  A. Goldberg,et al.  Coordinate activation of autophagy and the proteasome pathway by FoxO transcription factor , 2008, Autophagy.

[13]  J. Debnath,et al.  Induction of autophagy during extracellular matrix detachment promotes cell survival. , 2007, Molecular biology of the cell.

[14]  P. LoRusso,et al.  Biomarker development for XL765, a potent and selective oral dual inhibitor of PI3K and mTOR currently being administered to patients in a Phase I clinical trial , 2007 .

[15]  M. Waterfield,et al.  Pharmacologic characterization of a potent inhibitor of class I phosphatidylinositide 3-kinases. , 2007, Cancer research.

[16]  C. Bauvy,et al.  NF-κB Activation Represses Tumor Necrosis Factor-α-induced Autophagy* , 2006, Journal of Biological Chemistry.

[17]  P. Mayinger.  Faculty Opinions recommendation of A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling. , 2006 .

[18]  T. Khoury,et al.  Activated Akt and Erk Expression and Survival After Surgery in Pancreatic Carcinoma , 2006, Annals of Surgical Oncology.

[19]  Robbie Loewith,et al.  A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling , 2006, Cell.

[20]  William A Weiss,et al.  A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. , 2006, Cancer cell.

[21]  E. Greer,et al.  FOXO transcription factors at the interface between longevity and tumor suppression , 2005, Oncogene.

[22]  M. McMahon,et al.  Analysis of genomic DNA alterations and mRNA expression patterns in a panel of human pancreatic cancer cell lines , 2005, Genes, chromosomes & cancer.

[23]  Paul Tempst,et al.  Phosphorylation and Functional Inactivation of TSC2 by Erk Implications for Tuberous Sclerosisand Cancer Pathogenesis , 2005, Cell.

[24]  Philippe Dessen,et al.  Inhibition of Macroautophagy Triggers Apoptosis , 2005, Molecular and Cellular Biology.

[25]  B. Levine.  Eating Oneself and Uninvited Guests Autophagy-Related Pathways in Cellular Defense , 2005, Cell.

[26]  J. Hecht,et al.  Multicenter phase II study of the oral MEK inhibitor, CI-1040, in patients with advanced non-small-cell lung, breast, colon, and pancreatic cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[27]  Yixin Yao,et al.  The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells , 2004, Oncogene.

[28]  D. Bar-Sagi,et al.  Oncogenic K-ras Drives Cell Cycle Progression and Phenotypic Conversion of Primary Pancreatic Duct Epithelial Cells , 2004, Cancer Research.

[29]  I. Germano,et al.  Role of autophagy in temozolomide-induced cytotoxicity for malignant glioma cells , 2004, Cell Death and Differentiation.

[30]  O. Kotoulas,et al.  Electron microscopic and biochemical study of the effects of rapamycin on glycogen autophagy in the newborn rat liver , 2004, Microscopy research and technique.

[31]  Takeshi Noda,et al.  LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing , 2000, The EMBO journal.

[32]  J. Avruch,et al.  Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways , 1999, The Journal of Biological Chemistry.

[33]  C. Bauvy,et al.  NF-kappaB activation represses tumor necrosis factor-alpha-induced autophagy. , 2006, The Journal of biological chemistry.

[34]  J. Downward.  Targeting RAS signalling pathways in cancer therapy , 2003, Nature Reviews Cancer.

[35]  J. Testa,et al.  Frequent activation of AKT2 kinase in human pancreatic carcinomas , 2002, Journal of cellular biochemistry.

[36]  D. Klionsky,et al.  Autophagy, cytoplasm-to-vacuole targeting pathway, and pexophagy in yeast and mammalian cells. , 2000, Annual review of biochemistry.