Biocide Potency as Measured by Minimal Inhibitory Concentration * Preservative Pseudomonas aeruginosa Staphylococcus aureus Aspergillus niger Candida albicans

Anthony F. Fransway, MD,* Paulina J. Fransway, BS,† Donald V. Belsito, MD,‡ Erin M. Warshaw, MD,§ Denis Sasseville, MD,|| Joseph F. Fowler, Jr, MD,¶ Joel G. DeKoven, MD,# Melanie D. Pratt, MD,** Howard I. Maibach, MD,†† James S. Taylor, MD,‡‡ James G. Marks, MD,§§ C. G. Toby Mathias, MD,|||| Vincent A. DeLeo, MD,¶¶ J. Matthew Zirwas, MD,## Kathryn A. Zug, MD,*** Amber R. Atwater, MD,††† Jonathan Silverberg, MD,‡‡‡ and Margo J. Reeder, MD§§§

[1]  T. Slaga,et al.  Amended Safety Assessment of Parabens as Used in Cosmetics , 2020, International journal of toxicology.

[2]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch Test Results: 2015–2016 , 2018, Dermatitis : contact, atopic, occupational, drug.

[3]  Monica Rengifo-Pardo,et al.  Genital Allergic Contact Dermatitis , 2018, Dermatitis : contact, atopic, occupational, drug.

[4]  Ednei Gilberto Primel,et al.  Trace analysis of parabens preservatives in drinking water treatment sludge, treated, and mineral water samples , 2018, Environmental Science and Pollution Research.

[5]  T. Zuberbier,et al.  Lymphocyte surface markers and cytokines are suitable for detection and potency assessment of skin-sensitizing chemicals in an in vitro model of allergic contact dermatitis: the LCSA-ly , 2018, Archives of Toxicology.

[6]  E. Warshaw,et al.  Allergenic Ingredients in Facial Wet Wipes , 2017, Dermatitis : contact, atopic, occupational, drug.

[7]  A. Verma,et al.  Photosensitized methyl paraben induces apoptosis via caspase dependent pathway under ambient UVB exposure in human skin cells. , 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[8]  E. Warshaw,et al.  Allergenic Ingredients in Personal Hygiene Wet Wipes , 2017, Dermatitis : contact, atopic, occupational, drug.

[9]  J. Geier,et al.  The current spectrum of contact sensitization in patients with chronic leg ulcers or stasis dermatitis – new data from the Information Network of Departments of Dermatology (IVDK) , 2017, Contact dermatitis.

[10]  G. Deza,et al.  Allergic contact dermatitis in preservatives: current standing and future options , 2017, Current opinion in allergy and clinical immunology.

[11]  N. Yahaya,et al.  An ionic liquid loaded magnetically confined polymeric mesoporous adsorbent for extraction of parabens from environmental and cosmetic samples , 2017 .

[12]  Ronghua Chen,et al.  Determination of Six Paraben Residues in Fresh-cut Vegetables Using QuEChERS with Multi-walled Carbon Nanotubes and High-Performance Liquid Chromatography–Tandem Mass Spectrometry , 2017, Food Analytical Methods.

[13]  Kotryna Linauskienė,et al.  Time trends of contact allergy to the European baseline series in Lithuania , 2017, Contact Dermatitis.

[14]  R. Tamagawa‐Mineoka,et al.  Patch testing in patients with recurrent vesicular hand eczema. , 2017, Allergology International.

[15]  W. Uter,et al.  Contact allergy to preservatives: ESSCA* results with the baseline series, 2009–2012 , 2017, Journal of the European Academy of Dermatology and Venereology : JEADV.

[16]  A. Scheman,et al.  Contact Allergy Cross-reactions: Retrospective Clinical Data and Review of the Literature , 2017, Dermatitis : contact, atopic, occupational, drug.

[17]  P. Coenraads,et al.  Two decades of p‐phenylenediamine and toluene‐2,5‐diamine patch testing – focus on co‐sensitizations in the European baseline series and cross‐reactions with chemically related substances , 2017, Contact dermatitis.

[18]  Catherine Blake,et al.  Response to “Comment on ‘An Informatics Approach to Evaluating Combined Chemical Exposures from Consumer Products: A Case Study of Asthma-Associated Chemicals and Potential Endocrine Disruptors’” , 2016, Environmental health perspectives.

[19]  J. Thyssen,et al.  Contact Allergy to Preservatives—Is the European Commission a Commendable Risk Manager? , 2016 .

[20]  J. Treat,et al.  Potential Allergens in Disposable Diaper Wipes, Topical Diaper Preparations, and Disposable Diapers: Under-recognized Etiology of Pediatric Perineal Dermatitis , 2016, Dermatitis : contact, atopic, occupational, drug.

[21]  A. Goossens Cosmetic Contact Allergens , 2016 .

[22]  W. Boonchai,et al.  Cosmetic preservative labelling on the Thai market , 2016, Contact dermatitis.

[23]  A. Scheman,et al.  American Contact Dermatitis Society Contact Allergy Management Program: An Epidemiologic Tool to Determine Relative Prevalence of Contact Allergens , 2016, Dermatitis : contact, atopic, occupational, drug.

[24]  R. Stahlmann,et al.  Assessment of the sensitizing potency of preservatives with chance of skin contact by the loose-fit coculture-based sensitization assay (LCSA) , 2015, Archives of Toxicology.

[25]  D. Sasseville,et al.  “Parabenoia” Debunked, or “Who’s Afraid of Parabens?” , 2015, Dermatitis : contact, atopic, occupational, drug.

[26]  Gang Fu,et al.  PubChem Substance and Compound databases , 2015, Nucleic Acids Res..

[27]  J. Thyssen,et al.  Failures in risk assessment and risk management for cosmetic preservatives in Europe and the impact on public health , 2015, Contact dermatitis.

[28]  J. Geier,et al.  Contact sensitization in patients with suspected cosmetic intolerance: results of the IVDK 2006–2011 , 2015, Journal of the European Academy of Dermatology and Venereology : JEADV.

[29]  J. Thyssen,et al.  Is there a risk using hypoallergenic cosmetic pediatric products in the United States? , 2015, The Journal of allergy and clinical immunology.

[30]  S. Hernández-Díaz,et al.  Medications as a source of paraben exposure. , 2015, Reproductive toxicology.

[31]  K. Bandeen-Roche,et al.  Determinants of Exposure to Fragranced Product Chemical Mixtures in a Sample of Twins , 2015, International journal of environmental research and public health.

[32]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch Test Results: 2011–2012 , 2015, Dermatitis : contact, atopic, occupational, drug.

[33]  N. Al‐Mutairi,et al.  Resistant Palmoplantar Lesions in Patients of Psoriasis: Evaluation of the Causes and Comparison of the Frequency of Delayed-Type Hypersensitivity in Patients without Palm and Sole Lesions , 2014, Medical Principles and Practice.

[34]  A. Tosti,et al.  Contact Dermatitis Caused by Preservatives , 2014, Dermatitis : contact, atopic, occupational, drug.

[35]  J. Macfarlan West of Scotland , 2014 .

[36]  W. Uter,et al.  Coupled exposure to ingredients of cosmetic products: II. Preservatives , 2014, Contact dermatitis.

[37]  C. Goh,et al.  Contact Sensitivity to Preservatives in Singapore: Frequency of Sensitization to 11 Common Preservatives 2006–2011 , 2014, Dermatitis : contact, atopic, occupational, drug.

[38]  B. Demirhan,et al.  Antimicrobial and antibiofilm effects of selected food preservatives against Salmonella spp. isolated from chicken samples. , 2014, Poultry science.

[39]  Matthew R. Hall,et al.  Trends in patch-test results and allergen changes in the standard series: a Mayo Clinic 5-year retrospective review (January 1, 2006, to December 31, 2010). , 2014, Journal of the American Academy of Dermatology.

[40]  J. Yiannias,et al.  Allergy to Cosmetics: A Literature Review , 2013, Dermatitis : contact, atopic, occupational, drug.

[41]  C. Mowad,et al.  Allergic Contact Dermatitis in Dermatologic Surgery: Review of Common Allergens , 2013, Dermatitis : contact, atopic, occupational, drug.

[42]  Lingxin Chen,et al.  Occurrence of parabens in foodstuffs from China and its implications for human dietary exposure. , 2013, Environment international.

[43]  E. Warshaw,et al.  Patch Test Reactions Associated With Sunscreen Products and the Importance of Testing to an Expanded Series: Retrospective Analysis of North American Contact Dermatitis Group Data, 2001 to 2010 , 2013, Dermatitis : contact, atopic, occupational, drug.

[44]  J. Magdalou,et al.  Reviewing the binding of a series of parabens to human serum albumin , 2013, Biopharmaceutics & drug disposition.

[45]  R. Torgerson,et al.  Allergic Contact Dermatitis of the Vulva , 2013, Dermatitis : contact, atopic, occupational, drug.

[46]  J. V. van Engelen,et al.  Results of a cosmetovigilance survey in The Netherlands , 2013, Contact dermatitis.

[47]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch Test Results: 2009 to 2010 , 2013, Dermatitis : contact, atopic, occupational, drug.

[48]  Wei Zhang,et al.  Characteristic profiles of urinary p-hydroxybenzoic acid and its esters (parabens) in children and adults from the United States and China. , 2013, Environmental science & technology.

[49]  R. Nixon,et al.  Frequency of positive patch test reactions to preservatives: The Australian experience , 2013, The Australasian journal of dermatology.

[50]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch Test Results for 2007–2008 , 2013, Dermatitis : contact, atopic, occupational, drug.

[51]  F. Castelain,et al.  Parabens: a real hazard or a scare story? , 2012, European journal of dermatology : EJD.

[52]  S. Seidenari,et al.  Follow‐up of the monitored levels of preservative sensitivity in Europe. Overview of the years 2001–2008 , 2012, Contact dermatitis.

[53]  H. Eun,et al.  Multicenter study of preservative sensitivity in patients with suspected cosmetic contact dermatitis in Korea , 2012, The Journal of dermatology.

[54]  M. Yarmush,et al.  Perspectives on Non-Animal Alternatives for Assessing Sensitization Potential in Allergic Contact Dermatitis , 2012, Cellular and molecular bioengineering.

[55]  R. Nijhawan,et al.  Recommendations for a Screening Series for Allergic Contact Eyelid Dermatitis , 2012, Dermatitis : contact, atopic, occupational, drug.

[56]  W. Boonchai,et al.  Trend of contact allergy to cosmetic ingredients in Thais over a period of 10 years * , 2011, Contact dermatitis.

[57]  M. Deleuran,et al.  Contact allergy and allergic contact dermatitis in children – a review of current data , 2011, Contact dermatitis.

[58]  E. Warshaw,et al.  Part 4 of a 4-part series Miscellaneous Products: Trends and Alternatives in Deodorants, Antiperspirants, Sunblocks, Shaving Products, Powders, and Wipes: Data from the American Contact Alternatives Group. , 2011, The Journal of clinical and aesthetic dermatology.

[59]  F. Borrull,et al.  Determination of parabens in house dust by pressurised hot water extraction followed by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry. , 2011, Journal of chromatography. A.

[60]  A. Schnuch,et al.  Risk of sensitization to preservatives estimated on the basis of patch test data and exposure, according to a sample of 3541 leave‐on products , 2011, Contact dermatitis.

[61]  E. Warshaw,et al.  Part 3 of a 4-part series. Lip and common dental care products: trends and alternatives: data from the American Contact Alternatives Group. , 2011, The Journal of clinical and aesthetic dermatology.

[62]  Malin Lindstedt,et al.  A genomic biomarker signature can predict skin sensitizers using a cell-based in vitro alternative to animal tests , 2011, BMC Genomics.

[63]  E. Warshaw,et al.  Part 2 of a 4-part series Hair Products: Trends and Alternatives: Data from the American Contact Alternatives Group. , 2011, The Journal of clinical and aesthetic dermatology.

[64]  F. Hao,et al.  A retrospective study of patch tests in Chongqing, China from 2004 to 2009 , 2011, Contact dermatitis.

[65]  Jie-Ming Dong,et al.  Time trends of contact allergy to a modified European baseline series in Beijing between 2001 and 2006 , 2011, Contact dermatitis.

[66]  I. Duarte,et al.  Allergic contact dermatitis in private practice: what are the main sensitizers? , 2011, Dermatitis.

[67]  W Uter,et al.  Contact allergy to preservatives. Analysis of IVDK data 1996–2009 , 2011, The British journal of dermatology.

[68]  E. Warshaw,et al.  Part 1 of a 4-part series Facial Cosmetics: Trends and Alternatives: Data from the American Contact Alternatives Group. , 2011, The Journal of clinical and aesthetic dermatology.

[69]  G. D. de Gannes,et al.  Allergic contact dermatitis to preservatives and fragrances in cosmetics. , 2011, Skin therapy letter.

[70]  L. Landeck,et al.  Periorbital contact sensitization. , 2010, American journal of ophthalmology.

[71]  V. Mendiratta,et al.  Contact dermatitis in nurses and paramedicals in a tertiary care hospital of northern India. , 2010, Indian journal of dermatology, venereology and leprology.

[72]  Vinod K. Sharma,et al.  Pediatric contact dermatitis. , 2010, Indian journal of dermatology, venereology and leprology.

[73]  P. Gjersvik,et al.  Variability in patch test reactions – first report from the Norwegian Patch Test Registry * , 2010, Contact dermatitis.

[74]  J. Thyssen,et al.  Temporal trends of preservative allergy in Denmark (1985–2008) , 2010, Contact dermatitis.

[75]  H. Sasaki,et al.  Evaluation of Acute Corneal Barrier Change Induced by Topically Applied Preservatives Using Corneal Transepithelial Electric Resistance In Vivo , 2010, Cornea.

[76]  J. Marks Patch-test results of the North American contact dermatitis group 2005-2006 (Dermatitis (2009) 20, 3 (149-160)) , 2009 .

[77]  E. Warshaw,et al.  Patch‐Test Results of the North American Contact Dermatitis Group 2005‐2006 , 2009, Dermatitis : contact, atopic, occupational, drug.

[78]  A. Goossens,et al.  Contact allergy to fragrances and parabens in an atopic baby , 2009, Contact dermatitis.

[79]  C. Zachariae,et al.  Contamination versus preservation of cosmetics: a review on legislation, usage, infections, and contact allergy , 2009, Contact dermatitis.

[80]  Antonio Prado Moreno,et al.  Vlerick Leuven Gent Working Paper Series 2003/22 Starting Resource Configurations of Research-based Start-ups and the Interaction with Technology , 2022 .

[81]  Sarah A Stechschulte,et al.  Moisturizer allergy: diagnosis and management. , 2008, The Journal of clinical and aesthetic dermatology.

[82]  A. Alavi,et al.  Contact Allergens in Persons With Leg Ulcers: A Canadian Study in Contact Sensitization , 2008, The international journal of lower extremity wounds.

[83]  İ. Ertam,et al.  Patch‐Test Results of an Academic Department in Izmir, Turkey , 2008, Dermatitis : contact, atopic, occupational, drug.

[84]  V. Vašků,et al.  Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. , 2008, Acta dermatovenerologica Alpina, Pannonica, et Adriatica.

[85]  E. Warshaw,et al.  Anogenital dermatitis in patients referred for patch testing: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 1994-2004. , 2008, Archives of dermatology.

[86]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch‐Test Results, 2003‐2004 Study Period , 2008, Dermatitis : contact, atopic, occupational, drug.

[87]  B. Berne,et al.  Can the reporting of adverse skin reactions to cosmetics be improved? A prospective clinical study using a structured protocol , 2008, Contact dermatitis.

[88]  M. Pratt,et al.  Allergic Contact Dermatitis in Children: The Ottawa Hospital Patch‐Testing Clinic Experience, 1996 to 2006 , 2008, Dermatitis : contact, atopic, occupational, drug.

[89]  M. Zirwas,et al.  Allergens in Corticosteroid Vehicles , 2008, Dermatitis : contact, atopic, occupational, drug.

[90]  C. Charnock,et al.  Combining esters of para‐hydroxy benzoic acid (parabens) to achieve increased antimicrobial activity , 2007, Journal of clinical pharmacy and therapeutics.

[91]  D. Gawkrodger,et al.  Contact sensitivity to preservatives in the UK, 2004–2005: results of multicentre study , 2007, Contact dermatitis.

[92]  J. Johansen,et al.  20 Years of standard patch testing in an eczema population with focus on patients with multiple contact allergies , 2007, Contact dermatitis.

[93]  J. Geier,et al.  A further characteristic of susceptibility to contact allergy: sensitization to a weak contact allergen is associated with polysensitization. Results of the IVDK * , 2007, Contact dermatitis.

[94]  J. Chwalek An Analysis of Paraben Sensitivity in Patients Treated with Imiquimod: A Preliminary Report , 2007 .

[95]  E. Warshaw,et al.  Common Contact Allergens Associated with Eyelid Dermatitis: Data from the North American Contact Dermatitis Group 2003‐2004 Study Period , 2007, Dermatitis : contact, atopic, occupational, drug.

[96]  H. Maibach,et al.  Relationship of patch test positivity in a general versus an eczema population , 2007, Contact dermatitis.

[97]  Ian Kimber,et al.  Information derived from sensitization test methods: test sensitivity, false positives and false negatives , 2007, Contact dermatitis.

[98]  E. Warshaw,et al.  Cross‐reactions among Parabens, para‐Phenylenediamine, and Benzocaine: A Retrospective Analysis of Patch Testing , 2006, Dermatitis : contact, atopic, occupational, drug.

[99]  Donald V. Belsito,et al.  The aetiology of eyelid dermatitis: a 10‐year retrospective analysis , 2006, Contact dermatitis.

[100]  Y. Naito,et al.  Methylparaben potentiates UV-induced damage of skin keratinocytes. , 2006, Toxicology.

[101]  R. Bergman,et al.  Preservatives sensitivity in Israel: a 10‐year overview (1995–2004) , 2006, Contact dermatitis.

[102]  J. Sánchez‐Pérez,et al.  Allergic and systemic contact dermatitis to methylparaben , 2006, Contact dermatitis.

[103]  J. Yiannias,et al.  Patch test results from the Mayo Clinic Contact Dermatitis Group, 1998-2000. , 2005, Journal of the American Academy of Dermatology.

[104]  M. Soni,et al.  Safety assessment of esters of p-hydroxybenzoic acid (parabens). , 2005, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[105]  T. Luukkaala,et al.  Patch test reactions to cosmetic allergens in 1995–1997 and 2000–2002 in Finland – a multicentre study , 2005, Contact dermatitis.

[106]  E. Warshaw,et al.  Parabens: a review of epidemiology, structure, allergenicity, and hormonal properties. , 2005, Dermatitis : contact, atopic, occupational, drug.

[107]  A. Akyol,et al.  Contact sensitivity to preservatives in Turkey , 2005, Contact dermatitis.

[108]  H. Maibach,et al.  North American Contact Dermatitis Group Patch‐Test Results, 2001‐2002 Study Period , 2004, Dermatitis : contact, atopic, occupational, drug.

[109]  D. Sasseville Hypersensitivity to preservatives , 2004, Dermatologic therapy.

[110]  J. Geier,et al.  Allergic and non‐allergic periorbital dermatitis: patch test results of the Information Network of the Departments of Dermatology during a 5‐year period , 2004, Contact dermatitis.

[111]  V. Falanga,et al.  Contact sensitivity in patients with leg ulcerations: a North American study. , 2004, Archives of dermatology.

[112]  G. Angelini,et al.  Allergic Contact Dermatitis to Condoms: Description of a Clinical Case and Analytical Review of Current Literature , 2004, Immunopharmacology and immunotoxicology.

[113]  H. Maibach,et al.  North American Contact Dermatitis Group patch-test results, 1998 to 2000. , 2003, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

[114]  M. Soni,et al.  Evaluation of the health aspects of methyl paraben: a review of the published literature. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[115]  I. Duarte,et al.  Excited skin syndrome: study of 39 patients. , 2002, American Journal of Contact Dermatitis.

[116]  M. Kucenic,et al.  Occupational allergic contact dermatitis is more prevalent than irritant contact dermatitis: a 5-year study. , 2002, Journal of the American Academy of Dermatology.

[117]  H. Dickel,et al.  Occupational relevance of positive standard patch-test results in employed persons with an initial report of an occupational skin disease , 2002, International archives of occupational and environmental health.

[118]  S. Seidenari,et al.  Monitoring levels of preservative sensitivity in Europe , 2002, Contact dermatitis.

[119]  Esra Akasya-Hillenbrand,et al.  Patch test results in 542 patients with suspected contact dermatitis in Turkey , 2002, Contact dermatitis.

[120]  H. Wichmann,et al.  Epidemiology of contact allergy in adults , 2001, Allergy.

[121]  M. Soni,et al.  Safety assessment of propyl paraben: a review of the published literature. , 2001, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[122]  F. Lépine,et al.  Hydrolysis of 4-Hydroxybenzoic Acid Esters (Parabens) and Their Aerobic Transformation into Phenol by the Resistant Enterobacter cloacae Strain EM , 2001, Applied and Environmental Microbiology.

[123]  J. Vilaplana,et al.  Contact dermatitis from parabens used as preservatives in eyedrops. , 2000, Contact dermatitis.

[124]  E. Warshaw,et al.  North American Contact Dermatitis Group Patch Test Results 2013–2014 , 2000, Dermatitis : contact, atopic, occupational, drug.

[125]  I. Kimber,et al.  Use of the local lymph node assay for the estimation of relative contact allergenic potency , 2000, Contact dermatitis.

[126]  C. Mowad Allergic contact dermatitis caused by parabens: 2 case reports and a review. , 2000, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

[127]  J. S. Taylor,et al.  North American Contact Dermatitis Group patch-test results, 1996-1998. , 2000, Archives of dermatology.

[128]  E. González,et al.  Concomitant positive reactions to allergens in a patch testing standard series from 1988-1997. , 1999, American journal of contact dermatitis : official journal of the American Contact Dermatitis Society.

[129]  D. Grant,et al.  Physical properties of parabens and their mixtures: solubility in water, thermal behavior, and crystal structures. , 1999, Journal of pharmaceutical sciences.

[130]  S. Feldman,et al.  Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group. , 1999, Journal of the American Academy of Dermatology.

[131]  I. Vukšić,et al.  Allergic contact dermatitis in patients with leg ulcers , 1999, Contact dermatitis.

[132]  A. Bener,et al.  Allergic contact dermatitis in the United Arab Emirates , 1999, International journal of dermatology.

[133]  A. Goossens,et al.  Adverse cutaneous reactions to cosmetic allergens , 1999, Contact dermatitis.

[134]  D. Basketter REVIEW Skin sensitization: risk assessment , 1998, International journal of cosmetic science.

[135]  J. S. Taylor,et al.  North American Contact Dermatitis Group patch test results for the detection of delayed-type hypersensitivity to topical allergens. , 1998, Journal of the American Academy of Dermatology.

[136]  J. Geier,et al.  Patch testing with preservatives, antimicrobials and industrial biocides. Results from a multicentre study , 1998, The British journal of dermatology.

[137]  A. Goossens,et al.  [Contact allergy to cosmetics]. , 1997, Allergie et immunologie.

[138]  R. E. Marquis,et al.  Irreversible paraben inhibition of glycolysis by Streptococcus mutans GS‐5 , 1996, Letters in applied microbiology.

[139]  T. Hattel,et al.  Oral challenge with parabens in paraben‐sensitive patients , 1996, Contact dermatitis.

[140]  B. Berne,et al.  Adverse effects of cosmetics and toiletries reported to the Swedish Medical Products Agency 1989–1994 , 1996, Contact dermatitis.

[141]  J. Marks North American Contact Dermatitis Group standard tray patch test results (1992 to 1994) , 1996 .

[142]  T. Henseler,et al.  Evaluation of patch test results by use of the reaction index. An analysis of data recorded by the Information Network of Departments of Dermatology (IVDK) * , 1995, Contact dermatitis.

[143]  R. Rycroft,et al.  Patch testing with preservatives at St John's from 1982 to 1993 , 1995, Contact dermatitis.

[144]  J. Fowler,et al.  Fisher's Contact Dermatitis , 1995 .

[145]  R. Wolf,et al.  ANOTHER “PARABEN PARADOX” , 1995, International Journal of Dermatology.

[146]  N. Kruijf,et al.  Contents of methyl‐, ethyl‐, propyl‐, butyl‐ and benzylparaben in cosmetic products , 1995, Contact dermatitis.

[147]  A. Bircher,et al.  Frequency of sensitization to 13 common preservatives in Switzerland * , 1994, Contact dermatitis.

[148]  E. Buehler Occlusive patch method for skin sensitization in guinea pigs: the Buehler method. , 1994, Food and Chemical Toxicology.

[149]  J. Hansen,et al.  Paraben Contact Allergy: Patch Testing and In Vitro Absorption/metabolism , 1993 .

[150]  M. Bigby Contact and Occupational Dermatology , 1993 .

[151]  A. Fransway The Problem of Preservation in the 1990s: III. Agents With Preservative Function Independent of Formaldehyde Release , 1991 .

[152]  M. Beck,et al.  Epidemiological survey of standard series patch test results and observations on day 2 and day 4 readings , 1991, Contact dermatitis.

[153]  S. Shenoi,et al.  Sensitivity to various ingredients topical preparation following prolonged use , 1990, Contact dermatitis.

[154]  S. Seidenari,et al.  Patch and prick test study of 593 healthy subjects , 1990, Contact dermatitis.

[155]  S. Carradori,et al.  Systemic contact dermatitis due to parabens , 1990, Contact dermatitis.

[156]  L. E. Rosenthal,et al.  Prevalence and relevance of allergic reactions in patients patch tested in North America--1984 to 1985. , 1989, Journal of the American Academy of Dermatology.

[157]  J. Ring,et al.  Patch test results in 1987 compared to trends from the period 1977‐1983 , 1989, Contact dermatitis.

[158]  R. Graham,et al.  Delayed patch test reactions at days 7 and 9 , 1989, Contact dermatitis.

[159]  T. Menné,et al.  Routine patch testing with paraben esters , 1988, Contact dermatitis.

[160]  A. Groot,et al.  The role of contact allergy in the spectrum of adverse effects caused by cosmetics and toiletries , 1988, Contact dermatitis.

[161]  D. Hogan,et al.  Results of routine patch testing of 542 patients in Saskatoon, Canada , 1988, Contact dermatitis.

[162]  J. Ring,et al.  Trends in allergic contact sensitization , 1988, Contact dermatitis.

[163]  C. Goh Allergic Contact Dermatitis from Cosmetics , 1987, The Journal of dermatology.

[164]  W. Broeckx,et al.  Cosmetic intolerance , 1987, Contact dermatitis.

[165]  J. Vestey,et al.  An analysis of 501 consecutive contact clinic consultations , 1986, Contact dermatitis.

[166]  J. W. Weyland,et al.  Contact allergy to preservatives – II , 1986, Contact dermatitis.

[167]  J. W. Weyland,et al.  Contact allergy to preservatives (I) , 1986, Contact dermatitis.

[168]  H. Maibach,et al.  A five-year study of cosmetic reactions. , 1985, Journal of the American Academy of Dermatology.

[169]  A. Bajaj,et al.  Paraben Contact Hypersensitivity. , 1985, Indian Journal of Dermatology, Venereology and Leprology.

[170]  J. Marks,et al.  Immediate and delayed reactions to cosmetic ingredients , 1985, Contact dermatitis.

[171]  H. Maibach,et al.  Guinea Pig Allergy Tests: an Overview , 1985, Toxicology and industrial health.

[172]  G. Angelini,et al.  Allergic contact dermatitis to some medicaments , 1985, Contact dermatitis.

[173]  A. Groot,et al.  Patch tests with fragrance materials and preservatives , 1985, Contact dermatitis.

[174]  3 Final Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, and Butylparaben , 1984 .

[175]  I. Nes,et al.  The effect of parabens on DNA, RNA and protein synthesis in Escherichia coli and Bacillus subtilis. , 1983, The Journal of applied bacteriology.

[176]  C. Romaguera,et al.  Patch tests with allergens related to cosmetics , 1983, Contact dermatitis.

[177]  J. Mitchell,et al.  Screening patch tests in 4190 eczema patients 1972–81 , 1982, Contact dermatitis.

[178]  J. Nethercott Results of routine patch testing of 200 patients in Toronto, Canada * , 1982, Contact dermatitis.

[179]  S. Tyano,et al.  Delayed hypersensitivity reaction to orally administered methylparaben. , 1982, Clinical Pharmacist.

[180]  J. T. Atkinson,et al.  Prospective study of cosmetic reactions: 1977-1980 , 1982 .

[181]  H. Möller,et al.  Trends and forecasts for standard allergens in a 12‐year patch test material , 1982, Contact dermatitis.

[182]  Kunihiko Yoshikawa,et al.  Patch testing with European and American standard allergens in Japanese patients , 1982, Contact dermatitis.

[183]  C. Romaguera,et al.  Statistical and comparative study of 4600 patients tested in Barcelona (1973–1977) , 1980, Contact dermatitis.

[184]  O. Hammershøy Standard patch test results in 3,225 consecutive Danish patients from 1973 to 1977 , 1980, Contact dermatitis.

[185]  J. Lachapelle,et al.  Epidemiological survey of occupational contact dermatitis of the hands in Belgium , 1979, Contact dermatitis.

[186]  A. Blondeel,et al.  Contact allergy in 330 dermatological patients , 1978, Contact dermatitis.

[187]  P. Castelain,et al.  [Epidemiology of contact dermatitis in Marseilles (author's transl)]. , 1978, Annales de dermatologie et de vénéréologie.

[188]  Eugene M. Lepine Results of routine office patch testing , 1976, Contact dermatitis.

[189]  V. Pirilä,et al.  Allergy to ingredients of vehicles , 1976, Contact dermatitis.

[190]  H. Maibach,et al.  The frequency of contact sensitivity in North America 1972–74 North American Contact Dermatitis Group , 1975, Contact dermatitis.

[191]  A. Fisher Allergic paraben and benzyl alcohol hypersensitivity relationship of the “delayed” and “immediate” varieties , 1975, Contact dermatitis.

[192]  R. Brun Epidemiology of contact dermatitis in Geneva (1000 cases) , 1975, Contact dermatitis.

[193]  D. Nuss,et al.  Letter: Systemic eczematous "contact-type" dermatitis medicamentosa caused by parabens. , 1974, Archives of Dermatology.

[194]  J. Burry,et al.  ENVIRONMENTAL DERMATITIS: PATCH TESTS IN 1,000 CASES OF ALLERGIC CONTACT DERMATITIS , 1973, The Medical journal of Australia.

[195]  C. Sheu,et al.  Function of Lipophilic Acids as Antimicrobial Food Additives , 1973, Nature.

[196]  H. Maibach,et al.  Dermatitis from applied medicaments. , 1972, British medical journal.

[197]  E. Rudzki,et al.  THE EPIDEMIOLOGY OF CONTACT DERMATITIS IN POLAND , 1970, The British journal of dermatology.

[198]  G. Agrup Hand Eczema and Other Hand Dermatoses in South Sweden , 1970 .

[199]  H. Maibach,et al.  Recent experience with routine patch test screening. , 1968, Archives of dermatology.

[200]  W. F. Schorr Paraben allergy. A cause of intractable dermatitis. , 1968, JAMA.

[201]  S. Epstein Paraben sensitivity: subtle trouble. , 1968, Annals of allergy.

[202]  M. Reeder,et al.  Prevalence of Preservatives Across All Product Types in the Contact Allergen Management Program , 2017, Dermatitis : contact, atopic, occupational, drug.

[203]  Erwin van Vliet,et al.  Evaluation of the GARD assay in a blind Cosmetics Europe study. , 2017, ALTEX.

[204]  E. Warshaw,et al.  Occupational Contact Dermatitis in Mechanics and Repairers Referred for Patch Testing: Retrospective Analysis From the North American Contact Dermatitis Group 1998–2014 , 2017, Dermatitis : contact, atopic, occupational, drug.

[205]  B. Kręcisz,et al.  [Preservatives as important etiologic factors of allergic contact dermatitis]. , 2015, Medycyna pracy.

[206]  I. Eilks,et al.  Parabens as preservatives in personal care products , 2014 .

[207]  K. Issazadeh,et al.  ANTIMICROBIAL EFFICACY OF THE METHYLPARABEN AND BENZOATE SODIUM AGAINST SELECTED STANDARD MICROORGANISMS, CLINICAL AND ENVIRONMENTAL ISOLATES IN VITRO , 2014 .

[208]  Nilendu Sarma,et al.  Clinico-allergological pattern of allergic contact dermatitis among 70 Indian children. , 2010, Indian journal of dermatology, venereology and leprology.

[209]  V. Rogiers,et al.  ON Citric acid ( and ) Silver citrate , 2010 .

[210]  E. Warshaw,et al.  Allergic patch test reactions associated with cosmetics: retrospective analysis of cross-sectional data from the North American Contact Dermatitis Group, 2001-2004. , 2009, Journal of the American Academy of Dermatology.

[211]  B. Thiers Anogenital Dermatitis in Patients Referred for Patch Testing: Retrospective Analysis of Cross-sectional Data From the North American Contact Dermatitis Group, 1994-2004 , 2009 .

[212]  F. Alan Andersen,et al.  Final Amended Report on the Safety Assessment of Methylparaben, Ethylparaben, Propylparaben, Isopropylparaben, Butylparaben, Isobutylparaben, and Benzylparaben as used in Cosmetic Products 1 , 2008, International journal of toxicology.

[213]  J. Yiannias,et al.  Changing trends and allergens in the patch test standard series: a mayo clinic 5-year retrospective review, january 1, 2001, through december 31, 2005. , 2008, Archives of dermatology.

[214]  V. Rogiers,et al.  Scientific Committee on Consumer Products SCCP , 2007 .

[215]  C. Bindslev‐Jensen,et al.  Contact allergy and allergic contact dermatitis in adolescents: prevalence measures and associations. The Odense Adolescence Cohort Study on Atopic Diseases and Dermatitis (TOACS). , 2002, Acta dermato-venereologica.

[216]  J. Samet,et al.  Food and Drug Administration , 2007, BMJ : British Medical Journal.

[217]  G. Ergör,et al.  On Turkey. , 1996, Studies in family planning.

[218]  W. Paulus Microbiocides for the protection of materials: a handbook. , 1993 .

[219]  M K Robinson,et al.  A risk assessment process for allergic contact sensitization. , 1989, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[220]  K. Andersen,et al.  Systemic contact dermatitis. , 1988, Acta dermato-venereologica. Supplementum.

[221]  A. D. de Groot Contact allergy to cosmetics: causative ingredients. , 1987, Contact dermatitis.

[222]  E. Rudner North American Group results. , 1977, Contact dermatitis.

[223]  S. Husain Contact dermatitis in the West of Scotland. , 1977, Contact dermatitis.

[224]  T. Wernet,et al.  Topical parabens: benefits and risks. , 1977, Dermatologica.

[225]  Epidemiology of contact dermatitis in North America: 1972. , 1973, Archives of dermatology.

[226]  M. Lomuto,et al.  Additives, vehicles and active drugs of topical medicaments as causes of delayed-type allergic dermatitis. , 1971, Dermatologica.

[227]  H J Bandmann,et al.  Epidemiology of contact dermatitis. , 1969, Transactions of the St. John's Hospital Dermatological Society.

[228]  A. H. Mohajerin,et al.  Paraben sensitivity. , 1966, Archives of dermatology.