Dissociation of the effects of bilateral lesions of the dorsal hippocampus and parietal cortex on path integration in the rat.

Rodents are able to rely on self-motion (idiothetic) cues and navigate toward a reference place by path integration. The authors tested the effects of dorsal hippocampal and parietal lesions in a homing task to dissociate the respective roles of the hippocampus and the parietal cortex in path integration. Hippocampal rats exhibited a strong deficit in learning the basic task. Parietal rats displayed a performance impairment as a function of the complexity of their outward paths when the food was placed at varying locations. These results suggest that the parietal cortex plays a specific role in path integration and in the processing of idiothetic information, whereas the hippocampus is involved in the calibration of space used by the path integration system.

[1]  W. Krieg.  Connections of the cerebral cortex. I. The albino rat. A. Topography of the cortical areas , 1946 .

[2]  H. Rouanet,et al.  COMPARISON BETWEEN TREATMENTS IN A REPEATED‐MEASUREMENT DESIGN: ANOVA AND MULTIVARIATE METHODS , 1970 .

[3]  J. O'Keefe,et al.  The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat. , 1971, Brain research.

[4]  J. O’Keefe.  Place units in the hippocampus of the freely moving rat , 1976, Experimental Neurology.

[5]  L. Nadel,et al.  The Hippocampus as a Cognitive Map , 1978 .

[6]  E. Batschelet.  Circular statistics in biology , 1981 .

[7]  Thom Herrmann,et al.  Spatial problem solving by rats: Exploration and cognitive maps , 1982 .

[8]  M. Potegal.  Spatial abilities : development and physiological foundations , 1982 .

[9]  B. Kolb,et al.  Behavioural and anatomical studies of the posterior parietal cortex in the rat , 1987, Behavioural Brain Research.

[10]  I. Whishaw,et al.  Recovery from early cortical lesions in rats. III. Neonatal removal of posterior parietal cortex has greater behavioral and anatomical effects than similar removals in adulthood , 1987, Behavioural Brain Research.

[11]  J. Olavarria,et al.  Rats with lesions in anteromedial extrastriate cortex fail to learn a visuosomatic conditional response , 1987, Behavioural Brain Research.

[12]  R. Muller,et al.  The effects of changes in the environment on the spatial firing of hippocampal complex-spike cells , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[13]  T. Myhrer.  Exploratory behavior and reaction to novelty in rats with hippocampal perforant path systems disrupted. , 1988, Behavioral neuroscience.

[14]  Lucien T. Thompson,et al.  Persistence, reticence, and opportunism of place-field activity in hippocampal neurons , 1989 .

[15]  B. McNaughton,et al.  Cortical-hippocampal interactions and cognitive mapping: A hypothesis based on reintegration of the parietal and inferotemporal pathways for visual processing , 1989 .

[16]  R. Muller,et al.  The firing of hippocampal place cells in the dark depends on the rat's recent experience , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[17]  E Save,et al.  Object exploration and reactions to spatial and nonspatial changes in hooded rats following damage to parietal cortex or hippocampal formation. , 1992, Behavioral neuroscience.

[18]  S. Wiener.  Spatial and behavioral correlates of striatal neurons in rats performing a self-initiated navigation task , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[19]  E. J. Green,et al.  Cortical representation of motion during unrestrained spatial navigation in the rat. , 1994, Cerebral cortex.

[20]  A. Lavoie,et al.  Spatial, movement- and reward-sensitive discharge by medial ventral striatum neurons of rats , 1994, Brain Research.

[21]  B. McNaughton,et al.  Spatial information content and reliability of hippocampal CA1 neurons: Effects of visual input , 1994, Hippocampus.

[22]  A Berthoz,et al.  Inertial, Substratal and Landmark Cue Control of Hippocampal CA1 Place Cell Activity , 1995, The European journal of neuroscience.

[23]  B. McNaughton,et al.  Place cells, head direction cells, and the learning of landmark stability , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[24]  P E Sharp,et al.  Influences of vestibular and visual motion information on the spatial firing patterns of hippocampal place cells , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[25]  R. Muller,et al.  A Quarter of a Century of Place Cells , 1996, Neuron.

[26]  P E Sharp,et al.  Visual and vestibular influences on head-direction cells in the anterior thalamus of the rat. , 1995, Behavioral neuroscience.

[27]  J. Taube,et al.  Processing the head direction cell signal: A review and commentary , 1996, Brain Research Bulletin.

[28]  E. Save,et al.  Effects of parietal cortex lesions on spatial problem solving in the rat , 1996, Behavioural Brain Research.

[29]  E Save,et al.  Effects of lesions of the associative parietal cortex on the acquisition and use of spatial memory in egocentric and allocentric navigation tasks in the rat. , 1996, Behavioral neuroscience.

[30]  E. Bullmore,et al.  Society for Neuroscience Abstracts , 1997 .

[31]  George Paxinos,et al.  The Mouse Brain in Stereotaxic Coordinates , 2001 .

[32]  J. Taube,et al.  Firing Properties of Head Direction Cells in the Rat Anterior Thalamic Nucleus: Dependence on Vestibular Input , 1997, The Journal of Neuroscience.

[33]  SIMON BENHAMOU,et al.  Path integration by swimming rats , 1997, Animal Behaviour.

[34]  I. Whishaw,et al.  Piloting and dead reckoning dissociated by fimbria-fornix lesions in a rat food carrying task , 1997, Behavioural Brain Research.

[35]  B. McNaughton,et al.  Interactions between idiothetic cues and external landmarks in the control of place cells and head direction cells. , 1998, Journal of neurophysiology.

[36]  I. Whishaw,et al.  Rats with Fimbria–Fornix Lesions Are Impaired in Path Integration: A Role for the Hippocampus in “Sense of Direction” , 1998, The Journal of Neuroscience.

[37]  M. Moser,et al.  Functional differentiation in the hippocampus , 1998, Hippocampus.

[38]  Animal spatial cognition and exploration. , 1998 .

[39]  E. Save,et al.  The contribution of the associative parietal cortex and hippocampus to spatial processing in rodents , 1998, Psychobiology.

[40]  John Gigg,et al.  Disorientation combined with bilateral parietal cortex lesions causes path integration deficits in the water maze , 1999, Behavioural Brain Research.

[41]  I. Whishaw,et al.  Hippocampectomized rats are impaired in homing by path integration , 1999, Hippocampus.

[42]  J S Taube,et al.  Head Direction Cells in Rats with Hippocampal or Overlying Neocortical Lesions: Evidence for Impaired Angular Path Integration , 1999, The Journal of Neuroscience.

[43]  Ian Q. Whishaw,et al.  Path Integration Absent in Scent-Tracking Fimbria–Fornix Rats: Evidence for Hippocampal Involvement in “Sense of Direction” and “Sense of Distance” Using Self-Movement Cues , 1999, The Journal of Neuroscience.

[44]  I Q Whishaw,et al.  Calibrating space: Exploration is important for allothetic and idiothetic navigation , 1999, Hippocampus.

[45]  B. McNaughton,et al.  Hippocampectomized rats are capable of homing by path integration. , 1999, Behavioral neuroscience.

[46]  S. Mizumori,et al.  Retrosplenial cortex inactivation selectively impairs navigation in darkness. , 1999, Neuroreport.

[47]  E. Save,et al.  Contribution of multiple sensory information to place field stability in hippocampal place cells , 2000, Hippocampus.

[48]  E. Save,et al.  Hippocampal‐parietal cortical interactions in spatial cognition , 2000, Hippocampus.

[49]  S. Nishiike,et al.  Corticofugal connections between the cerebral cortex and the vestibular nuclei in the rat , 2000, The Journal of comparative neurology.

[50]  M A Arbib,et al.  Competitive Hebbian learning and the hippocampal place cell system: Modeling the interaction of visual and path integration cues , 2001, Hippocampus.