Age effects on interrelationships between lung volume and heart rate during standing.

To determine the effects of aging and posture on the relationship between respiration and heart rate (HR), we collected 5 min of lung volume and R-R interval data from 7 young (27 ± 3 yr, mean ± SD) and 10 old (69 ± 6 yr) healthy humans during spontaneous breathing while they were supine (SU) and standing (ST). Lung volume and HR power spectra and transfer functions between lung volume and HR were estimated. Age and position effects and age-position interactions were determined by analysis of variance for repeated measures. Older subjects had a lower and more variable respiration rate ( P < 0.03, P < 0.04), but both age groups exhibited decreased rate of respiration and increased tidal volume with ST ( P < 0.05, P < 0.005). ST decreased lung volume-to-HR transfer function magnitude in both groups ( P < 0.07). The more marked age-related differences were in phase angle. Both SU and ST phase angles were greater in older subjects ( P < 0.003). ST decreased phase angle in young but increased phase angle in older subjects ( P < 0.001). In conclusion, respiration, and respiration-HR interrelationships are altered by aging, with increased time delays between lung volume and HR and altered relationships with ST.

[1]  B. J. Winer.  Statistical Principles in Experimental Design , 1992 .

[2]  D. G. Watts,et al.  Spectral analysis and its applications , 1968 .

[3]  W C Dement,et al.  Respiration during sleep in the aged human. , 1981, Journal of gerontology.

[4]  R. Cohen,et al.  Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control. , 1981, Science.

[5]  M. Littner,et al.  Awake abnormalities of control of breathing and of the upper airway. Occurrence in healthy older men with nocturnal disordered breathing. , 1984, Chest.

[6]  D. Adam,et al.  Assessment of autonomic function in humans by heart rate spectral analysis. , 1985, The American journal of physiology.

[7]  R. Cohen,et al.  Hemodynamic regulation: investigation by spectral analysis. , 1985, The American journal of physiology.

[8]  F. Witkowski,et al.  Mechanisms controlling cardiac autonomic function and their relation to arrhythmogenesis , 1986 .

[9]  T. J. Breen,et al.  Biostatistical Analysis (2nd ed.). , 1986 .

[10]  R. Cohen,et al.  An Efficient Algorithm for Spectral Analysis of Heart Rate Variability , 1986, IEEE Transactions on Biomedical Engineering.

[11]  Glenn A. Myers,et al.  Power Spectral Analysis of Heart Rate Varability in Sudden Cardiac Death: Comparison to Other Methods , 1986, IEEE Transactions on Biomedical Engineering.

[12]  D H Singer,et al.  Power spectral analysis of heart rate variability in sudden cardiac death: comparison to other methods. , 1986, IEEE transactions on bio-medical engineering.

[13]  D. Shannon,et al.  Aging of modulation of heart rate. , 1987, The American journal of physiology.

[14]  Z. Zakov,et al.  The Heart and Cardiovascular System--Scientific Foundations , 1987 .

[15]  D. Silage,et al.  Spectral analysis of ventilation in elderly subjects awake and asleep. , 1988, Journal of applied physiology.

[16]  Richard J. Cohen,et al.  Estimation of heart rate power spectrum bands from real-world data: dealing with ectopic beats and noisy data , 1988, Proceedings. Computers in Cardiology 1988.

[17]  R J Cohen,et al.  Beat to beat variability in cardiovascular variables: noise or music? , 1989, Journal of the American College of Cardiology.

[18]  J. Saul,et al.  Transfer function analysis of autonomic regulation. I. Canine atrial rate response. , 1989, The American journal of physiology.

[19]  R.D. Berger,et al.  Assessment of autonomic response by broad-band respiration , 1989, IEEE Transactions on Biomedical Engineering.

[20]  J. Saul,et al.  Transfer function analysis of autonomic regulation. II. Respiratory sinus arrhythmia. , 1989, The American journal of physiology.

[21]  J. Saul,et al.  Beat-to-Beat Variations of Heart Rate Reflect Modulation of Cardiac Autonomic Outflow , 1990 .

[22]  G. Moody,et al.  Spectral characteristics of heart rate variability before and during postural tilt. Relations to aging and risk of syncope. , 1990, Circulation.

[23]  J. Saul,et al.  Transfer function analysis of the circulation: unique insights into cardiovascular regulation. , 1991, The American journal of physiology.

[24]  A. Malliani,et al.  Cardiovascular Neural Regulation Explored in the Frequency Domain , 1991, Circulation.

[25]  W. J. Gibb,et al.  Aging effects on heart rate variation. , 1991, Journal of gerontology.

[26]  A. Goldberger,et al.  Loss of 'complexity' and aging. Potential applications of fractals and chaos theory to senescence. , 1992, JAMA.

[27]  J. Cacioppo,et al.  Respiratory sinus arrhythmia: autonomic origins, physiological mechanisms, and psychophysiological implications. , 1993, Psychophysiology.

[28]  D. T. Kaplan,et al.  The Analysis of Variability , 1994, Journal of cardiovascular electrophysiology.

[29]  R W Barnes,et al.  Age, race, and sex differences in autonomic cardiac function measured by spectral analysis of heart rate variability--the ARIC study. Atherosclerosis Risk in Communities. , 1995, The American journal of cardiology.

[30]  G. Piccirillo,et al.  Age-adjusted normal confidence intervals for heart rate variability in healthy subjects during head-up tilt. , 1995, International journal of cardiology.

[31]  N. Craft,et al.  Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans. , 1995, The American journal of physiology.

[32]  A Malliani,et al.  Effects of aging and of chronic obstructive pulmonary disease on RR interval variability. , 1996, Journal of the autonomic nervous system.

[33]  D Verotta,et al.  Age and autonomic effects on interrelationships between lung volume and heart rate. , 1996, The American journal of physiology.