The TRAIL receptor agonist drozitumab targets basal B triple-negative breast cancer cells that express vimentin and Axl
暂无分享,去创建一个
S. Steinberg | S. Hewitt | S. Swain | S. Lipkowitz | L. Amiri-Kordestani | Anand S. Merchant | Y. Greer | D. Voeller | J. Dine | C. Conway | C. O'Sullivan | K. J. Chavez | Brandon Stone | S. Sinclair
[1] A. Ashkenazi. Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions. , 2015, The Journal of clinical investigation.
[2] S. Marsters,et al. E-cadherin couples death receptors to the cytoskeleton to regulate apoptosis. , 2014, Molecular cell.
[3] T. D’alfonso,et al. Axl receptor tyrosine kinase expression in breast cancer , 2014, Journal of Clinical Pathology.
[4] J. von Pawel,et al. Phase II trial of mapatumumab, a fully human agonist monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), in combination with paclitaxel and carboplatin in patients with advanced non-small-cell lung cancer. , 2014, Clinical lung cancer.
[5] P. Holland. Death receptor agonist therapies for cancer, which is the right TRAIL? , 2014, Cytokine & growth factor reviews.
[6] G. Tse,et al. P-cadherin and vimentin are useful basal markers in breast cancers. , 2013, Human pathology.
[7] Jun Hong,et al. AXL mediates TRAIL resistance in esophageal adenocarcinoma. , 2013, Neoplasia.
[8] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumours , 2013 .
[9] Steven J. M. Jones,et al. Comprehensive molecular portraits of human breast tumors , 2012, Nature.
[10] S. Lipkowitz,et al. WEE1 Inhibition Sensitizes Basal Breast Cancer Cells to TRAIL-Induced Apoptosis , 2011, Molecular Cancer Research.
[11] X. Chen,et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. , 2011, The Journal of clinical investigation.
[12] A. Yang,et al. An Fcγ receptor-dependent mechanism drives antibody-mediated target-receptor signaling in cancer cells. , 2011, Cancer cell.
[13] Charles M. Perou,et al. Deconstructing the molecular portraits of breast cancer , 2010, Molecular oncology.
[14] K. Hess,et al. DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer. , 2011, The oncologist.
[15] J. Vose,et al. A Phase 1b/2 trial of mapatumumab in patients with relapsed/refractory non-Hodgkin's lymphoma , 2010, British Journal of Cancer.
[16] Charles M Perou,et al. Molecular stratification of triple-negative breast cancers. , 2010, The oncologist.
[17] Jason I. Herschkowitz,et al. Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer , 2010, Breast Cancer Research.
[18] J. L. Costa,et al. P-cadherin, vimentin and CK14 for identification of basal-like phenotype in breast carcinomas: an immunohistochemical study. , 2010, Histology and histopathology.
[19] R. Herbst,et al. Phase I dose-escalation study of recombinant human Apo2L/TRAIL, a dual proapoptotic receptor agonist, in patients with advanced cancer. , 2010, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[20] R. Herbst,et al. A Phase I Safety and Pharmacokinetic Study of the Death Receptor 5 Agonistic Antibody PRO95780 in Patients with Advanced Malignancies , 2010, Clinical Cancer Research.
[21] V. Heinemann,et al. Phase II trial of mapatumumab, a fully human agonistic monoclonal antibody that targets and activates the tumour necrosis factor apoptosis-inducing ligand receptor-1 (TRAIL-R1), in patients with refractory colorectal cancer , 2010, British Journal of Cancer.
[22] S. Lipkowitz,et al. Triple negative breast cancer cell lines: one tool in the search for better treatment of triple negative breast cancer. , 2010, Breast disease.
[23] N. Caplen,et al. Identification of WEE1 as a potential molecular target in cancer cells by RNAi screening of the human tyrosine kinome , 2010, Breast Cancer Research and Treatment.
[24] J. Pumphrey,et al. The TRAIL to targeted therapy of breast cancer. , 2009, Advances in cancer research.
[25] P. Meltzer,et al. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype , 2008, Breast Cancer Research and Treatment.
[26] D. Lawrence,et al. Structural and functional analysis of the interaction between the agonistic monoclonal antibody Apomab and the proapoptotic receptor DR5 , 2008, Cell Death and Differentiation.
[27] C. Perou,et al. Epidemiology of basal-like breast cancer , 2008, Breast Cancer Research and Treatment.
[28] G. Cavet,et al. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL , 2007, Nature Medicine.
[29] A. Rosenberg,et al. Differences in breast carcinoma characteristics in newly diagnosed African–American and Caucasian patients , 2007, Cancer.
[30] B. Rubino,et al. The role of epithelial-mesenchymal transition in cancer pathology. , 2007, Pathology.
[31] C. Perou,et al. The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes , 2007, Clinical Cancer Research.
[32] J. Benítez,et al. Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas , 2006, Journal of Clinical Pathology.
[33] Wen-Lin Kuo,et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. , 2006, Cancer cell.
[34] C. Perou,et al. Race, breast cancer subtypes, and survival in the Carolina Breast Cancer Study. , 2006, JAMA.
[35] C. Perou,et al. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma , 2006, Modern Pathology.
[36] G. Sauter,et al. Changes in Cytoskeletal Protein Composition Indicative of an Epithelial-Mesenchymal Transition in Human Micrometastatic and Primary Breast Carcinoma Cells , 2005, Clinical Cancer Research.
[37] C. Caldas,et al. Molecular classification and molecular forecasting of breast cancer: ready for clinical application? , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[38] L. Holmberg,et al. Gene expression profiling spares early breast cancer patients from adjuvant therapy: derived and validated in two population-based cohorts , 2005, Breast Cancer Research.
[39] P. Hall,et al. An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[40] A. Rosenberg,et al. Differences in breast carcinoma characteristics in newly diagnosed African-American and Caucasian patients: A single-institution compilation compared with the National Cancer Institute SEER database , 2005 .
[41] J. Foekens,et al. Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer , 2005, The Lancet.
[42] Z. Gatalica,et al. Benign myoepithelial tumors of the breast have immunophenotypic characteristics similar to metaplastic matrix-producing and spindle cell carcinomas. , 2003, American journal of clinical pathology.
[43] A. Ashkenazi,et al. Targeting death and decoy receptors of the tumour-necrosis factor superfamily , 2002, Nature Reviews Cancer.
[44] F. Meric,et al. Expression profile of tyrosine kinases in breast cancer. , 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.
[45] E. Dreher,et al. Estrogen dependent expression of the receptor tyrosine kinase axl in normal and malignant human breast. , 2001, Annals of oncology : official journal of the European Society for Medical Oncology.
[46] Christian A. Rees,et al. Molecular portraits of human breast tumours , 2000, Nature.
[47] Emad S. Alnemri,et al. Temperature-sensitive Differential Affinity of TRAIL for Its Receptors , 2000, The Journal of Biological Chemistry.
[48] D. Lawrence,et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. , 1999, The Journal of clinical investigation.
[49] M. Nau,et al. Chemotherapy augments TRAIL-induced apoptosis in breast cell lines. , 1999, Cancer research.
[50] C. Rauch,et al. Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo , 1999, Nature Medicine.
[51] G M Cohen,et al. Caspases: the executioners of apoptosis. , 1997, The Biochemical journal.
[52] G. Shah,et al. Cleavage of poly(ADP-ribose) polymerase: a sensitive parameter to study cell death. , 1997, Biochemistry and cell biology = Biochimie et biologie cellulaire.