Serum IL‐17A concentration and a IL17RA single nucleotide polymorphism contribute to the risk of autoimmune type 1 diabetes

Interleukin (IL)‐17 is associated with autoimmunity. This study aimed to affirm the role of IL‐17A, IL‐17F and single nucleotide polymorphisms (SNPs) in genes related to them and their receptors in autoimmune type 1 diabetes (T1D) for Chinese population.

[1]  Wei-Wei Zhang,et al.  IL-17A is involved in diabetic inflammatory pathogenesis by its receptor IL-17RA , 2020, Experimental biology and medicine.

[2]  C. Garcés,et al.  Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group , 2020, BMJ open diabetes research & care.

[3]  D. Sabry,et al.  A potential association between psoriasin to rs4819554 of IL-17RA gene polymorphism in psoriasis Egyptian patients , 2019, Archives of Dermatological Research.

[4]  F. Antonicelli,et al.  Characteristic Pattern of IL-17RA, IL-17RB, and IL-17RC in Monocytes/Macrophages and Mast Cells From Patients With Bullous Pemphigoid , 2019, Front. Immunol..

[5]  S. Gaffen,et al.  The IL-17 Family of Cytokines in Health and Disease. , 2019, Immunity.

[6]  Heming Guo,et al.  Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes Susceptibility , 2018, Journal of diabetes research.

[7]  Y. Chen,et al.  CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function , 2018, Scientific Reports.

[8]  Tao Yang,et al.  Rs2227982 and rs2227981 in PDCD1 gene are functional SNPs associated with T1D risk in East Asian , 2018, Acta Diabetologica.

[9]  M. Craig,et al.  Maternal virus infections in pregnancy and type 1 diabetes in their offspring: Systematic review and meta‐analysis of observational studies , 2018, Reviews in medical virology.

[10]  G. Allam,et al.  The potential pathogenic role of IL-17/Th17 cells in both type 1 and type 2 diabetes mellitus. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[11]  W. Jia,et al.  Incidence of type 1 diabetes in China, 2010-13: population based study , 2018, British Medical Journal.

[12]  S. Esposito,et al.  Type 1 diabetes and viral infections: What is the relationship? , 2017, Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.

[13]  Xiao-Xi Zhang,et al.  Correlation between serum interleukin‐6 level and type 1 diabetes mellitus: A systematic review and meta‐analysis , 2017, Cytokine.

[14]  V. Mohan,et al.  Increased serum levels of novel T cell cytokines IL-33, IL-9 and IL-17 in subjects with type-1 diabetes. , 2016, Cytokine.

[15]  W. Hagopian,et al.  HLA Genetic Discrepancy Between Latent Autoimmune Diabetes in Adults and Type 1 Diabetes: LADA China Study No. 6. , 2016, The Journal of clinical endocrinology and metabolism.

[16]  A. Peet,et al.  Increased Blood Levels of Growth Factors, Proinflammatory Cytokines, and Th17 Cytokines in Patients with Newly Diagnosed Type 1 Diabetes , 2015, PloS one.

[17]  E. Bonifacio,et al.  The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study , 2015, Diabetologia.

[18]  M. Songini,et al.  High GADA titer increases the risk of insulin requirement in LADA patients: a 7-year follow-up (NIRAD study 7). , 2014, European journal of endocrinology.

[19]  J. Ilonen,et al.  Role of Type 1 Diabetes–Associated SNPs on Risk of Autoantibody Positivity in the TEDDY Study , 2014, Diabetes.

[20]  Tao Yang,et al.  Increased Th22 cells are independently associated with Th17 cells in type 1 diabetes , 2014, Endocrine.

[21]  C. Gu,et al.  IL-17 family: cytokines, receptors and signaling. , 2013, Cytokine.

[22]  W. Fung-Leung,et al.  Gender-biased regulation of human IL-17-producing cells in vitro by peptides corresponding to distinct HLA-DRB1 allele-coded sequences. , 2013, Journal of immune based therapies, vaccines and antimicrobials.

[23]  J. Myśliwska,et al.  The Serum IL-6 Profile and Treg/Th17 Peripheral Cell Populations in Patients with Type 1 Diabetes , 2013, Mediators of inflammation.

[24]  Chen Wang,et al.  The −1123G>C Variant of PTPN22 Gene Promoter is Associated with Latent Autoimmune Diabetes in Adult Chinese Hans , 2012, Cell Biochemistry and Biophysics.

[25]  E. Bonifacio,et al.  Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes , 2011, Diabetes.

[26]  A. Valdés,et al.  Genetics of the HLA Region in the Prediction of Type 1 Diabetes , 2011, Current diabetes reports.

[27]  Andrew P Morris,et al.  Basic statistical analysis in genetic case-control studies , 2011, Nature Protocols.

[28]  J. Ilonen,et al.  IL-17 Immunity in Human Type 1 Diabetes , 2010, The Journal of Immunology.

[29]  A. Kimura,et al.  IL‐6: Regulator of Treg/Th17 balance , 2010, European journal of immunology.

[30]  S. Tan,et al.  DNA, RNA, and Protein Extraction: The Past and The Present , 2009, Journal of biomedicine & biotechnology.

[31]  S. Gaffen.  Structure and signalling in the IL-17 receptor family , 2009, Nature Reviews Immunology.

[32]  C. Sasakawa,et al.  Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses. , 2009, Immunity.

[33]  V. Trajković,et al.  Interleukin-17 stimulates inducible nitric oxide synthase-dependent toxicity in mouse beta cells , 2005, Cellular and Molecular Life Sciences.

[34]  H. Erlich,et al.  The distribution of HLA class II susceptible/protective haplotypes could partially explain the low incidence of type 1 diabetes in continental Italy (Lazio region). , 2001, Tissue antigens.

[35]  C. Jagger,et al.  Determinants of raised C-reactive protein concentration in type 1 diabetes. , 2000, QJM : monthly journal of the Association of Physicians.

[36]  P. Zimmet,et al.  Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus. Provisional report of a WHO Consultation , 1998, Diabetic medicine : a journal of the British Diabetic Association.

[37]  Laura Marshall,et al.  Type 1 diabetes mellitus , 2017, Nature Reviews Disease Primers.

[38]  C. Pipper,et al.  Neonatal levels of adiponectin, interleukin-10 and interleukin-12 are associated with the risk of developing type 1 diabetes in childhood and adolescence: A nationwide Danish case-control study. , 2017, Clinical immunology.