Ornithine as a precursor of glutamate and GABA: Uptake and metabolism by neuronal and glial enriched cellular material

The uptake and metabolism of (U‐14C) L‐omithine by several cellular preparations was examined and compared to corresponding data for glutamine and α‐ketoglutarate. Five fractions were obtained from the cerebellum of 10‐to 14‐day‐old mice; two fractions were enriched in astrocyte cell bodies, whereas one was comprised primarily of granule cell bodies, and another was enriched in nerve terminals. Metabolic studies were also conducted on two synaptosomal preparations prepared from rat cerebral tissue.

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