REPRODUCTIVE HEALTH EFFECTS OF CONSANGUINEOUS MARRIAGES IN KHYBER PAKHTUNKHWA

Objectives: To explore the health effects of consanguinity in particular the pregnancy outcome, infant mortality and congenital malformations in Khyber Pakhtunkhwa. Material and Methods: Present study was carried in Gynae "B" Labour Room / Gynae "B" ward Khyber Teaching Hospital from November 2013 to April 2014. Two hundred cases including 100 consanguineous and 100 non con- sanguineous patients as control, representative of all geographic locations in KPK were randomly selected to find out the relationship of reproductive health problem with consanguinity. This study indicates a predominant public health problems associated with cousin marriage and a need for specific genetic counseling. Results: A total of 200 cases were studied, 100 in the consanguineous and 100 in the non-consanguineous marriage group. Main outcome measures were health effects of consanguinity in terms of pregnancy outcome including live births, abortion and still births, infant mortality and congenital mal formations. In the first group abortions were 11% as compared 3% in the 2nd group intrauterine deaths were 7% in the consanguineous group and 2% in the non-consan- guineous group. Congenital malformations were 12% in the consanguineous and only 1% in the non-consanguineous marriage group. The infantile death rate was also high in consanguineous group being 7% as compared to 2% in the non-consanguineous group.

[1]  N. Dedeoğlu,et al.  The frequency and medical effects of consanguineous marriages in Antalya, Turkey. , 2008, Hereditas.

[2]  Bernadette Modell,et al.  Genetic counselling and customary consanguineous marriage , 2002, Nature Reviews Genetics.

[3]  R. Hussain,et al.  Consanguinity and early mortality in the muslim populations of India and Pakistan , 2001, American journal of human biology : the official journal of the Human Biology Council.

[4]  M. Shohat,et al.  The Impact of Consanguinity Worldwide , 1998, Public Health Genomics.

[5]  N. LamdouarBouazzaoui.  Consanguinity and public health in Morocco , 1994 .

[6]  E. Beşer,et al.  Consanguineous marriages in the province of Trabzon, Turkey. , 1992, East African medical journal.

[7]  A. Bittles,et al.  Consanguinity related prenatal and postnatal mortality of the populations of seven Pakistani Punjab cities. , 1989, Journal of medical genetics.

[8]  John Tj,et al.  Reproductive wastage and developmental disorders in relation to consanguinity in south India. , 1981 .

[9]  M. Jadhav,et al.  Fetal growth and parental consanguinity , 1979, Archives of disease in childhood.

[10]  N. Shinozaki,et al.  Inbreeding in Japan: Results of a nation-wide study. , 1975, Jinrui idengaku zasshi. The Japanese journal of human genetics.

[11]  W. Schull,et al.  The effect of parental consanguinity and inbreeding in Hirado, Japan , 1970, Humangenetik.

[12]  L. D. Sanghvi.  Inbreeding in India. , 1966, Social biology.

[13]  H. Slatis,et al.  Consanguineous marriages in the Chicago region. , 1958, American journal of human genetics.

[14]  A. Soulaymani,et al.  Etude de la consanguinité dans la population marocaine. Impact sur le profil de la santé , 2007 .

[15]  B. Modell,et al.  Science and society: genetic counselling and customary consanguineous marriage. , 2002, Nature reviews. Genetics.

[16]  M. A. Hashmi.  Frequency of consanguinity and its effect on congenital malformation--a hospital based study. , 1997, JPMA. The Journal of the Pakistan Medical Association.

[17]  R. Lancashire,et al.  Why do UK-born Pakistani babies have high perinatal and neonatal mortality rates? , 1991, Paediatric and perinatal epidemiology.

[18]  N. Saha,et al.  Inbreeding effects on reproductive outcome in a Sudanese population. , 1990, Human heredity.

[19]  S. Shami.  Inbred and non-inbred first cousin marriages. , 1983, JPMA. The Journal of the Pakistan Medical Association.

[20]  V. Reddy,et al.  Effects of parental consanguinity on fertility, mortality and morbidity among the Pattusalis of Tirupati, South Indian. , 1978, Human heredity.