Insights into the Oocyte GV to MII Transition and Mammalian Ageing

Dr. Panagiotis Ntostis1*, Dr. Agni Pantou2, Dr. John Huntriss1 and Dr. Helen M Picton1 1Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK 2Genesis Athens Clinic, Reproductive Medicine Unit, Athens, Greece *Corresponding Author: Dr. Panagiotis Ntostis, Discovery and Translational Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine, School of Medicine, University of Leeds, Leeds, UK.

[1]  Robert C. Blanshard,et al.  Chromosome errors in human eggs shape natural fertility over reproductive life span , 2019, Science.

[2]  Dan Wang,et al.  Mitochondrial dysfunction and endoplasmic reticulum stress involved in oocyte aging: an analysis using single-cell RNA-sequencing of mouse oocytes , 2019, Journal of Ovarian Research.

[3]  Ping Liu,et al.  Transcriptome Landscape of Human Folliculogenesis Reveals Oocyte and Granulosa Cell Interactions. , 2018, Molecular cell.

[4]  B. Vollenhoven,et al.  Ovarian ageing and the impact on female fertility , 2018, F1000Research.

[5]  L. Rienzi,et al.  Impact of Maternal Age on Oocyte and Embryo Competence , 2018, Front. Endocrinol..

[6]  P. Villesen,et al.  Granulosa cells from human primordial and primary follicles show differential global gene expression profiles , 2018, Human reproduction.

[7]  Z. Roth Symposium review: Reduction in oocyte developmental competence by stress is associated with alterations in mitochondrial function. , 2018, Journal of dairy science.

[8]  R. Krisher,et al.  Differing molecular response of young and advanced maternal age human oocytes to IVM , 2017, Human reproduction.

[9]  A. Schweitzer,et al.  The transcriptome of human oocytes is related to age and ovarian reserve , 2017, Molecular human reproduction.

[10]  P. Villesen,et al.  Dormancy and activation of human oocytes from primordial and primary follicles: molecular clues to oocyte regulation , 2017, Human reproduction.

[11]  V. Desquiret-Dumas,et al.  Ovarian ageing: the role of mitochondria in oocytes and follicles. , 2016, Human reproduction update.

[12]  Jaswant Singh,et al.  Meta-analysis of gene expression profiles in granulosa cells during folliculogenesis. , 2016, Reproduction.

[13]  Matthew Rabinowitz,et al.  Effects of maternal age on euploidy rates in a large cohort of embryos analyzed with 24-chromosome single-nucleotide polymorphism-based preimplantation genetic screening. , 2016, Fertility and sterility.

[14]  J. Chitwood,et al.  RNA‐Seq profiling of single bovine oocyte transcript abundance and its modulation by cytoplasmic polyadenylation , 2015, Molecular reproduction and development.

[15]  N. Treff,et al.  The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening. , 2014, Fertility and sterility.

[16]  M. Lampson,et al.  Chromosome Cohesion Decreases in Human Eggs with Advanced Maternal Age. , 2012 .

[17]  H. Schatten,et al.  The effects of postovulatory aging of mouse oocytes on methylation and expression of imprinted genes at mid-term gestation. , 2011, Molecular human reproduction.

[18]  S. Oehninger,et al.  The association of reproductive senescence with mitochondrial quantity, function, and DNA integrity in human oocytes at different stages of maturation. , 2011, Fertility and sterility.

[19]  F. Broekmans,et al.  Ovarian aging: mechanisms and clinical consequences. , 2009, Endocrine reviews.

[20]  Xiang-yang Zou,et al.  Mitochondrial functions on oocytes and preimplantation embryos , 2009, Journal of Zhejiang University SCIENCE B.

[21]  H. Schatten,et al.  Loss of methylation imprint of Snrpn in postovulatory aging mouse oocyte. , 2008, Biochemical and biophysical research communications.

[22]  Geraldine Seydoux,et al.  Regulation of the Oocyte-to-Zygote Transition , 2007, Science.

[23]  J. Affourtit,et al.  Selective degradation of transcripts during meiotic maturation of mouse oocytes. , 2007, Developmental biology.

[24]  M. Duchen,et al.  Regulation of redox metabolism in the mouse oocyte and embryo , 2006, Development.

[25]  Michael Lynch,et al.  Mutation Pressure and the Evolution of Organelle Genomic Architecture , 2006, Science.

[26]  T. A. Santos,et al.  Mitochondrial content reflects oocyte variability and fertilization outcome. , 2006, Fertility and sterility.

[27]  P. Reynier,et al.  Low oocyte mitochondrial DNA content in ovarian insufficiency. , 2005, Human reproduction.

[28]  G. Wessel,et al.  How to make an egg: transcriptional regulation in oocytes. , 2005, Differentiation; research in biological diversity.

[29]  A. Sharov,et al.  Age-associated alteration of gene expression patterns in mouse oocytes. , 2004, Human molecular genetics.

[30]  J. Cummins The role of mitochondria in the establishment of oocyte functional competence. , 2004, European journal of obstetrics, gynecology, and reproductive biology.

[31]  H. Igarashi,et al.  Impact of oxidative stress in aged mouse oocytes on calcium oscillations at fertilization , 2003, Molecular reproduction and development.

[32]  A. Raziel,et al.  Increased frequency of female partner chromosomal abnormalities in patients with high-order implantation failure after in vitro fertilization. , 2002, Fertility and sterility.

[33]  J. Tarín,et al.  Postovulatory Aging of Oocytes Decreases Reproductive Fitness and Longevity of Offspring1 , 2002, Biology of reproduction.

[34]  B Dale,et al.  Mitochondrial aggregation patterns and activity in human oocytes and preimplantation embryos. , 2001, Human reproduction.

[35]  P Barrière,et al.  Mitochondrial DNA content affects the fertilizability of human oocytes. , 2001, Molecular human reproduction.

[36]  H. Wu,et al.  Injection of Sperm Cytosolic Factor Into Mouse Metaphase II Oocytes Induces Different Developmental Fates According to the Frequency of [Ca2+]i Oscillations and Oocyte Age1 , 2000, Biology of reproduction.

[37]  Z. Xu,et al.  Spontaneous activation of ovulated mouse eggs: time-dependent effects on M-phase exit, cortical granule exocytosis, maternal messenger ribonucleic acid recruitment, and inositol 1,4,5-trisphosphate sensitivity. , 1997, Biology of reproduction.

[38]  J. Grifo,et al.  Embryo morphology, developmental rates, and maternal age are correlated with chromosome abnormalities. , 1995, Fertility and sterility.

[39]  C. Hutchison,et al.  Maternal inheritance of mammalian mitochondrial DNA , 1974, Nature.

[40]  Alexandre Webster,et al.  Mechanisms of Aneuploidy in Human Eggs. , 2017, Trends in cell biology.

[41]  V. Franke,et al.  Sculpting the Transcriptome During the Oocyte-to-Embryo Transition in Mouse. , 2015, Current topics in developmental biology.

[42]  K. Konishi,et al.  Oxidative phosphorylation-linked respiration in individual bovine oocytes. , 2012, The Journal of reproduction and development.

[43]  U. Eichenlaub-Ritter Oocyte ageing and its cellular basis. , 2012, The International journal of developmental biology.

[44]  J. van Blerkom Mitochondrial function in the human oocyte and embryo and their role in developmental competence. , 2011, Mitochondrion.

[45]  Jacques Cohen,et al.  Maternal age-related differential global expression profiles observed in human oocytes. , 2007, Reproductive biomedicine online.

[46]  M. Duchen,et al.  The role of mitochondrial function in the oocyte and embryo. , 2007, Current topics in developmental biology.

[47]  J. van Blerkom Mitochondria in human oogenesis and preimplantation embryogenesis: engines of metabolism, ionic regulation and developmental competence. , 2004, Reproduction.