Double Para-testicular Cellular Angiofibroma and Synchronous Testicular Microlithiasis

Cellular angiofibroma is a rare benign mesenchymal tumor. Since first described by Nucci et al. in 1997 [1], this distinct histopathologic entity has been reported in a series of studies [2-4] and case reports [5-7]. The tumor is characterized by two principal components, cellular spindle cells and prominent blood vessels [1]. Mild cytologic atypia and a few mitotic figures have been demonstrated in some cases [2,4]. The tumor occurs mainly in the inguinoscrotal region in men [2-5,7]. The molecular pathogenesis of cellular angiofibroma is largely unknown, although retinoblastoma 1 (RB1) and forkhead box protein O1 (FOXO1) have been implicated in some cases [3,7]. Testicular microlithiasis is a relatively rare condition characterized by calcifications within the seminiferous tubules. Two different types of testicular microlithiasis, hematoxylin bodies and laminated calcifications, have been described [8]. Many laminated calcifications have been associated with atrophic seminiferous tubules or germ cell neoplasia [8,9]. Here, we present a case of double para-testicular cellular angiofibroma and synchronous testicular microlithiasis.