Integrins: emerging paradigms of signal transduction.

Integrins receive signals from other receptors that lead to activation of ligand binding (inside-out signaling) and matrix assembly. Upon binding ligands, they also activate intracellular signaling pathways. These signals converse with pathways that are initiated by soluble ligands to regulate cell functions. In this way, cell adhesion is coordinated with other events to orchestrate complex cellular behavior.

[1]  B. Mayer,et al.  The product of the cellular crk gene consists primarily of SH2 and SH3 regions. , 1992, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[2]  J. Fessler,et al.  The lethal myospheroid gene of Drosophila encodes a membrane protein homologous to vertebrate integrin beta subunits. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[3]  R. D. Wade,et al.  Amino acid sequence of human von Willebrand factor. , 1986, Biochemistry.

[4]  J. Folkman,et al.  Interaction of serum and cell spreading affects the growth of neoplastic and non-neoplastic fibroblasts. , 1981, Journal of supramolecular structure and cellular biochemistry.

[5]  P. Hadváry,et al.  Low molecular weight, non-peptide fibrinogen receptor antagonists. , 1992, Journal of medicinal chemistry.

[6]  R. Kretsinger,et al.  Structure and evolution of calcium-modulated proteins. , 1980, CRC critical reviews in biochemistry.

[7]  Y. Takada,et al.  A point mutation of integrin beta 1 subunit blocks binding of alpha 5 beta 1 to fibronectin and invasin but not recruitment to adhesion plaques , 1992, The Journal of cell biology.

[8]  C. O'neill,et al.  Anchorage and growth regulation in normal and virus‐transformed cells , 1968, International journal of cancer.

[9]  T. Sasaki,et al.  Involvement of rho p21 and its inhibitory GDP/GTP exchange protein (rho GDI) in cell motility , 1993, Molecular and cellular biology.

[10]  S. Hanks,et al.  Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases , 1995, Molecular and cellular biology.

[11]  Timothy A. Springer,et al.  Adhesion receptors of the immune system , 1990, Nature.

[12]  A. Hall,et al.  Ras-related GTPases and the cytoskeleton. , 1992, Molecular biology of the cell.

[13]  J. Folkman,et al.  Role of cell shape in growth control , 1978, Nature.

[14]  T. Hunter,et al.  Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase , 1994, Nature.

[15]  A. Frelinger,et al.  Selective inhibition of integrin function by antibodies specific for ligand-occupied receptor conformers. , 1990, The Journal of biological chemistry.

[16]  R. Isberg,et al.  Multiple β 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells , 1990, Cell.

[17]  C. Heldin,et al.  Dimerization of cell surface receptors in signal transduction , 1995, Cell.

[18]  R. Hynes,et al.  Defects in mesoderm, neural tube and vascular development in mouse embryos lacking fibronectin. , 1993, Development.

[19]  J. Caen,et al.  An Abnormal Platelet Glycoprotein Pattern in Three Cases of Glanzmann's Thrombasthenia , 1974, British journal of haematology.

[20]  A. O'Rourke,et al.  Cytotoxic T-lymphocyte activation involves a cascade of signalling and adhesion events , 1992, Nature.

[21]  Jonathan Boyd,et al.  The three-dimensional structure of the tenth type III module of fibronectin: An insight into RGD-mediated interactions , 1992, Cell.

[22]  Kenneth M. Yamada,et al.  Regulation of fibronectin receptor distribution [published erratum appears in J Cell Biol 1992 Jul;118(2):491] , 1992, The Journal of cell biology.

[23]  M. Humphries,et al.  The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine. , 1991, The Journal of biological chemistry.

[24]  D. Cheresh,et al.  Integrin α v β 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels , 1994, Cell.

[25]  R. Liddington,et al.  Crystal structure of the A domain from the a subunit of integrin CR3 (CD11 b/CD18) , 1995, Cell.

[26]  C. Morimoto,et al.  Ligation of VLA-4 on T cells stimulates tyrosine phosphorylation of a 105-kD protein , 1992, The Journal of experimental medicine.

[27]  J. Brugge,et al.  Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3. , 1994, The Journal of biological chemistry.

[28]  K. Yamada,et al.  "Inside-out" signal transduction inhibited by isolated integrin cytoplasmic domains. , 1994, The Journal of biological chemistry.

[29]  S. Hanks,et al.  Focal adhesion kinase is abundant in developing blood vessels and elevation of its phosphotyrosine content in vascular smooth muscle cells is a rapid response to angiotensin II , 1994, Journal of cellular biochemistry.

[30]  K. Fujisawa,et al.  ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells. , 1993, The Journal of biological chemistry.

[31]  T. Stossel.  On the crawling of animal cells. , 1993, Science.

[32]  K. Horgan,et al.  Regulated expression and binding of three VLA (β1) integrin receptors on T cells , 1990, Nature.

[33]  R. Schnaar,et al.  Tumor cell haptotaxis on covalently immobilized linear and exponential gradients of a cell adhesion peptide. , 1989, Developmental biology.

[34]  S. Kanner,et al.  Human T and B lymphocytes express a structurally conserved focal adhesion kinase, pp125FAK. , 1993, DNA and cell biology.

[35]  R. Hynes,et al.  A LARGE GLYCOPROTEIN LOST FROM THE SURFACES OF TRANSFORMED CELLS * , 1978, Annals of the New York Academy of Sciences.

[36]  N. Green,et al.  Electron microscopy and structural model of human fibronectin receptor. , 1988, The EMBO journal.

[37]  CHAPTER IV – The Role of Proteins , 1958 .

[38]  M. Arnaout,et al.  A novel divalent cation-binding site in the a domain of the β 2 integrin CR3 (CD11b/CD18) is essential for ligand binding , 1993, Cell.

[39]  M. Ginsberg,et al.  The ligand binding site of the platelet integrin receptor GPIIb-IIIa is proximal to the second calcium binding domain of its alpha subunit. , 1990, The Journal of biological chemistry.

[40]  C. Turner,et al.  Primary sequence of paxillin contains putative SH2 and SH3 domain binding motifs and multiple LIM domains: identification of a vinculin and pp125Fak-binding region. , 1994, Journal of cell science.

[41]  Y. Hannun,et al.  12(S)-HETE enhancement of prostate tumor cell invasion: selective role of PKC alpha. , 1994, Journal of the National Cancer Institute.

[42]  C. Nobes,et al.  Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia , 1995, Cell.

[43]  R. Tucker,et al.  Cell shape and increased free cytosolic calcium [Ca2+]i induced by growth factors. , 1990, Cell calcium.

[44]  S Grinstein,et al.  Na+/H+ exchange and growth factor-induced cytosolic pH changes. Role in cellular proliferation. , 1989, Biochimica et biophysica acta.

[45]  P. Hadváry,et al.  The integrin alpha IIb-beta 3, platelet glycoprotein IIb-IIIa, can form a functionally active heterodimer complex without the cysteine-rich repeats of the beta 3 subunit. , 1994, The Journal of biological chemistry.

[46]  J. Tschopp,et al.  Design and synthesis of novel cyclic RGD-containing peptides as highly potent and selective integrin alpha IIb beta 3 antagonists. , 1994, Journal of medicinal chemistry.

[47]  S. Ogawa,et al.  A novel signaling molecule, p130, forms stable complexes in vivo with v‐Crk and v‐Src in a tyrosine phosphorylation‐dependent manner. , 1994, The EMBO journal.

[48]  C. Marshall,et al.  Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation , 1995, Cell.

[49]  T. Kirchhausen,et al.  Arrangement of domains, and amino acid residues required for binding of vascular cell adhesion molecule-1 to its counter-receptor VLA-4 (alpha 4 beta 1) , 1994, The Journal of cell biology.

[50]  Anne J. Ridley,et al.  The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors , 1992, Cell.

[51]  K. Burridge,et al.  Tyrosine phosphorylation is involved in reorganization of the actin cytoskeleton in response to serum or LPA stimulation. , 1994, Journal of cell science.

[52]  P. Bates,et al.  Integrin LFA‐1 alpha subunit contains an ICAM‐1 binding site in domains V and VI. , 1994, The EMBO journal.

[53]  A. Horwitz,et al.  Integrin (the CSAT antigen): functionality requires oligomeric integrity , 1986, The Journal of cell biology.

[54]  L. Molony,et al.  Inhibition of Molt-4-endothelial adherence by synthetic peptides from the sequence of ICAM-1. , 1992, The Journal of biological chemistry.

[55]  J. Brugge,et al.  Detection of Src homology 3-binding proteins, including paxillin, in normal and v-Src-transformed Balb/c 3T3 cells. , 1993, The Journal of biological chemistry.

[56]  Y. Yazaki,et al.  Matrix/Integrin Interaction Activates the Mitogen-activated Protein Kinase, p44 and p42(*) , 1995, The Journal of Biological Chemistry.