Solubility Measurements of Chloramphenicol in Supercritical Fluid CO2 Using Static Solubility Apparatus Interfaced with Online Supercritical Fluid Chromatography

The solubility of chloramphenicol in pure supercritical fluid carbon dioxide (SF-CO2) has been determined using a continuously stirred supercritical solubility vessel (SSV) directly interfaced with online supercritical fluid chromatography (SFC) using a single valve interface. Solubility measurements were performed at two temperatures of 313 and 333 K with pressures ranging from 10 to 26 MPa. For each individually loaded sample, a series of increasingly more saturated chloramphenicol solutions were prepared in situ by ramping the SF-CO2 pressure within the SSV in 2 or 3 MPa steps. Once equilibrium dissolution was established at each pressure step value, online SFC solubility measurements were performed. The combined SSV–SFC instrumentation and methodology enabled the rapid acquisition of chloramphenicol SF-CO2 solubility data. Chloramphenicol exhibited limited solubility in SF-CO2, providing mole fraction solubility values of 4.9 × 10–6 to 9.9 × 10–6 within the experimental range studied. All sets of SSV–...

[1]  Wei Guo,et al.  Determining phenol partition coefficient values in water- and industrial process water-supercritical CO2 systems using direct aqueous SFE apparatus simultaneously interfaced with on-line SFC and on-line HPLC , 2019, The Journal of Supercritical Fluids.

[2]  A. Myerson,et al.  Estimation of the Solubility of Metastable Polymorphs: A Critical Review , 2018, Crystal Growth & Design.

[3]  Wei Guo,et al.  Measuring the Solubility of Anthracene and Chrysene in Supercritical Fluid Carbon Dioxide Using Static Solubility Apparatus Directly Interfaced Online to Supercritical Fluid Chromatography , 2018 .

[4]  Ž. Knez,et al.  Solubility of Solids in Sub- and Supercritical Fluids: A Review 2010–2017 , 2017 .

[5]  Wei Guo,et al.  Determining the Solubility of Nifedipine and Quinine in Supercritical Fluid Carbon Dioxide Using Continuously Stirred Static Solubility Apparatus Interfaced with Online Supercritical Fluid Chromatography , 2017 .

[6]  R. Smith,et al.  Solubility of flavone, 6-methoxyflavone and anthracene in supercritical CO2 with/without a co-solvent of ethanol correlated by using a newly proposed entropy-based solubility parameter , 2016 .

[7]  Wei Guo,et al.  Interfacing supercritical fluid solubility apparatus with supercritical fluid chromatography operated with and without on-line post-column derivatization: Determining the solubility of caffeine and monensin in supercritical carbon dioxide , 2016 .

[8]  Wei Guo,et al.  Determining the Solubility of Organic Compounds in Supercritical Carbon Dioxide Using Supercritical Fluid Chromatography Directly Interfaced to Supercritical Fluid Solubility Apparatus , 2016 .

[9]  K. M. Sharif,et al.  Particle formation and micronization using non-conventional techniques- review , 2014 .

[10]  Shiang‐Tai Lin,et al.  A predictive method for the solubility of drug in supercritical carbon dioxide , 2014 .

[11]  M. Sandahl,et al.  Impact of injection solvents on supercritical fluid chromatography. , 2013, Journal of chromatography. A.

[12]  S. Singh,et al.  Supercritical fluid technology: a promising approach in pharmaceutical research , 2013, Pharmaceutical development and technology.

[13]  C. Ghotbi,et al.  Solubilities of acetaminophen in supercritical carbon dioxide with and without menthol cosolvent: Measurement and correlation , 2012 .

[14]  Premanjali Rai,et al.  Modeling and optimization of reductive degradation of chloramphenicol in aqueous solution by zero-valent bimetallic nanoparticles , 2012, Environmental Science and Pollution Research.

[15]  Željko Knez,et al.  Solubility of Solids in Sub- and Supercritical Fluids: a Review , 2011 .

[16]  L. A. Galicia-Luna,et al.  New Apparatus for Solubility Measurements of Solids in Carbon Dioxide , 2011 .

[17]  X. H. Wu,et al.  2.74 – Supercritical Fluids , 2011 .

[18]  Yun Wang,et al.  Extraction and determination of chloramphenicol in feed water, milk, and honey samples using an ionic liquid/sodium citrate aqueous two-phase system coupled with high-performance liquid chromatography , 2011, Analytical and bioanalytical chemistry.

[19]  G. Madras,et al.  An association model for the solubilities of pharmaceuticals in supercritical carbon dioxide , 2010 .

[20]  Maw-rong Lee,et al.  Supercritical fluid extraction in situ derivatization for simultaneous determination of chloramphenicol, florfenicol and thiamphenicol in shrimp , 2010 .

[21]  M. J. Cocero,et al.  Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications , 2009 .

[22]  K. Mishima.  Biodegradable particle formation for drug and gene delivery using supercritical fluid and dense gas. , 2008, Advanced drug delivery reviews.

[23]  T. Bruno,et al.  Solubility of Capsaicin and β-Carotene in Supercritical Carbon Dioxide and in Halocarbons† , 2001 .

[24]  R. Kumar,et al.  Phase Behavior of Mixtures Containing Antibiotics. Chloramphenicol Partitioning , 1997 .

[25]  J. Hampson.  A Recirculating Equilibrium Procedure for Determining Organic Compound Solubility in Supercritical Fluids. Anthracene in Carbon Dioxide , 1996 .

[26]  M. Barzegar,et al.  On-Line coupling of supercritical fluid extraction with high performance liquid chromatography , 1995 .

[27]  L. T. Taylor,et al.  Supercritical Fluid Extraction of Phenols from Water , 1992 .

[28]  K. Bartle,et al.  Solubilities of solids and liquids of low volatility in supercritical carbon dioxide , 1991 .

[29]  Sunwook Kim,et al.  Modeling Supercritical Mixtures: How Predictive Is It? , 1989 .