Safety and Metabolism of Long-term Administration of NIAGEN (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults

[1]  Mark S. Schmidt,et al.  Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter , 2019, Nature Metabolism.

[2]  O. Naveiras,et al.  The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. , 2019, Cell stem cell.

[3]  I. Vrabas,et al.  Acute nicotinamide riboside supplementation improves redox homeostasis and exercise performance in old individuals: a double-blind cross-over study , 2019, European Journal of Nutrition.

[4]  C. Brenner,et al.  Pterostilbene raises low density lipoprotein cholesterol in people. , 2019, Clinical Nutrition.

[5]  Mark S. Schmidt,et al.  Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring. , 2019, Cell reports.

[6]  S. Bruzzone,et al.  Slc12a8 is a nicotinamide mononucleotide transporter , 2018, Nature Metabolism.

[7]  Mark S. Schmidt,et al.  A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. , 2018, The American journal of clinical nutrition.

[8]  Qingzhi Wang,et al.  Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance. , 2018, Biochemical and biophysical research communications.

[9]  M. McQueen,et al.  Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults , 2018, Nature Communications.

[10]  J. Baur,et al.  NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR. , 2017, Cell metabolism.

[11]  C. Brenner,et al.  Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy , 2017, Circulation.

[12]  R. Tian,et al.  An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers , 2017, PloS one.

[13]  Mark S. Schmidt,et al.  Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity‐induced axonal degeneration , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  L. Guarente,et al.  Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safely and sustainably: a randomized, double-blind, placebo-controlled study , 2017, npj Aging and Mechanisms of Disease.

[15]  Mingzhu Zhai,et al.  Comparison of the effects of nicotinic acid and nicotinamide degradation on plasma betaine and choline levels. , 2017, Clinical nutrition.

[16]  D. Gregori,et al.  Definition of a tolerable upper intake level of niacin: a systematic review and meta‐analysis of the dose‐dependent effects of nicotinamide and nicotinic acid supplementation , 2017, Nutrition reviews.

[17]  C. Brenner,et al.  Nicotinamide riboside kinases display redundancy in mediating nicotinamide mononucleotide and nicotinamide riboside metabolism in skeletal muscle cells , 2017, Molecular metabolism.

[18]  Mark S. Schmidt,et al.  Nicotinamide riboside, a form of vitamin B3 and NAD+ precursor, relieves the nociceptive and aversive dimensions of paclitaxel-induced peripheral neuropathy in female rats , 2017, Pain.

[19]  J. Auwerx,et al.  NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells , 2016, Nature Communications.

[20]  Mark S. Schmidt,et al.  Nicotinamide riboside is uniquely and orally bioavailable in mice and humans , 2016, Nature Communications.

[21]  C. Miao,et al.  Hepatic NAD+ deficiency as a therapeutic target for non‐alcoholic fatty liver disease in ageing , 2016, British journal of pharmacology.

[22]  R. Kardon,et al.  Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice , 2016, Scientific Reports.

[23]  Liping Yu,et al.  Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk. , 2016, The Journal of nutrition.

[24]  C. Kruger,et al.  Safety assessment of nicotinamide riboside, a form of vitamin B3 , 2016, Human & experimental toxicology.

[25]  L. Sturla,et al.  Antitumor effect of combined NAMPT and CD73 inhibition in an ovarian cancer model , 2015, Oncotarget.

[26]  E. Verdin NAD+ in aging, metabolism, and neurodegeneration , 2015, Science.

[27]  C. Brenner,et al.  NNMT: A Bad Actor in Fat Makes Good in Liver. , 2015, Cell metabolism.

[28]  J. Milbrandt,et al.  SARM1 activation triggers axon degeneration locally via NAD+ destruction , 2015, Science.

[29]  Biykem Bozkurt,et al.  2014 ACC/AHA guideline on perioperative cardiovascular evaluation and management of patients undergoing noncardiac surgery: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. , 2014, Circulation.

[30]  S. Jaffrey,et al.  Activation of SIRT3 by the NAD⁺ precursor nicotinamide riboside protects from noise-induced hearing loss. , 2014, Cell metabolism.

[31]  L. Guarente,et al.  NAD+ and sirtuins in aging and disease. , 2014, Trends in cell biology.

[32]  M. Griswold,et al.  Pterostilbene on Metabolic Parameters: A Randomized, Double-Blind, and Placebo-Controlled Trial , 2014, Evidence-based complementary and alternative medicine : eCAM.

[33]  Jennifer G. Robinson,et al.  2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. , 2014, Circulation.

[34]  Jennifer G. Robinson,et al.  2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines , 2014, Circulation.

[35]  A. Sugawara,et al.  The CD38-Cyclic ADP-Ribose System in Mammals: Historical Background, Pathophysiology and Perspective , 2014 .

[36]  P. Sachdev,et al.  Mapping NAD+ metabolism in the brain of ageing Wistar rats: potential targets for influencing brain senescence , 2014, Biogerontology.

[37]  M. Drazner,et al.  2013 ACCF/AHA guideline for the management of heart failure: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. , 2013, Journal of the American College of Cardiology.

[38]  L. Sturla,et al.  CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells* , 2013, The Journal of Biological Chemistry.

[39]  L. Guarente,et al.  The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling , 2013, Cell.

[40]  C. Brenner,et al.  Targeted, LCMS-based Metabolomics for Quantitative Measurement of NAD+ Metabolites , 2013, Computational and structural biotechnology journal.

[41]  J. Auwerx,et al.  The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. , 2012, Cell metabolism.

[42]  N. Braidy,et al.  NAD+ metabolism and oxidative stress: the golden nucleotide on a crown of thorns , 2012, Redox report : communications in free radical research.

[43]  A. Nikiforov,et al.  Pathways and Subcellular Compartmentation of NAD Biosynthesis in Human Cells , 2011, The Journal of Biological Chemistry.

[44]  C. Deng,et al.  Recent progress in the biology and physiology of sirtuins , 2009, Nature.

[45]  C. Brenner,et al.  Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD+ precursor vitamins in human nutrition. , 2008, Annual review of nutrition.

[46]  Ting-kai Li,et al.  Determinants of alcohol use and abuse: Impact of quantity and frequency patterns on liver disease , 2007, Hepatology.

[47]  C. Brenner,et al.  Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+ , 2007, Cell.

[48]  H. Bays,et al.  Safety considerations with niacin therapy. , 2007, The American journal of cardiology.

[49]  J. Milbrandt,et al.  Stimulation of Nicotinamide Adenine Dinucleotide Biosynthetic Pathways Delays Axonal Degeneration after Axotomy , 2006, The Journal of Neuroscience.

[50]  C. Brenner,et al.  Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans , 2004, Cell.

[51]  G. Poirier,et al.  PARP-1, a determinant of cell survival in response to DNA damage. , 2003, Experimental hematology.

[52]  D. Sinclair,et al.  Inhibition of Silencing and Accelerated Aging by Nicotinamide, a Putative Negative Regulator of Yeast Sir2 and Human SIRT1* , 2002, The Journal of Biological Chemistry.

[53]  G. Sedgwick,et al.  Niacin (nicotinic acid) in non-physiological doses causes hyperhomocysteineaemia in Sprague–Dawley rats , 2002, British Journal of Nutrition.

[54]  D. Hunninghake,et al.  Niacin treatment increases plasma homocyst(e)ine levels. , 1999, American heart journal.

[55]  G. Omenn,et al.  A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes. , 1995, JAMA.

[56]  R. Jacob,et al.  Biochemical markers for assessment of niacin status in young men: levels of erythrocyte niacin coenzymes and plasma tryptophan. , 1989, Journal of NutriLife.

[57]  W. J. Turner,et al.  Metabolic response of humans to ingestion of nicotinic acid and nicotinamide. , 1976, Clinical chemistry.

[58]  K. Chao,et al.  Nicotinamide methyltransferase and S-adenosylmethionine: 5'-methylthioadenosine hydrolase. Control of transfer ribonucleic acid methylation. , 1973, Biochemistry.

[59]  M. Horwitt Niacin-tryptophan relationships in the development of pellagra. , 1955, The American journal of clinical nutrition.

[60]  G. Cantoni Methylation of nicotinamide with soluble enzyme system from rat liver. , 1951, The Journal of biological chemistry.

[61]  R. E. Butler,et al.  A REACTION TO THE ORAL ADMINISTRATION OF NICOTINIC ACID , 1938 .

[62]  Jennifer G. Robinson,et al.  Reprint: 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults. , 2013, Journal of the American Pharmacists Association : JAPhA.

[63]  C. Brenner,et al.  NAD+ metabolism in health and disease. , 2007, Trends in biochemical sciences.

[64]  BY G. L. CANTONIt METHYLATION OF NICOTINAMIDE WITH A SOLUBLE ENZYME SYSTEM FROM RAT LIVER* , 2003 .

[65]  Opinion of the Scientific Committee on Food on the Tolerable Upper Intake level of Nicotinic Acid and Nicotinamide (Niacin) , 2002 .

[66]  its Panel on Folate,et al.  Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline , 1998 .