Cell Receptor Gene Rearrangements Define a Monoclonal T Cell Proliferation in Patients With T Cell Lymphocytosis and Cytopenia

We have used probes from the T cell receptor fi and ‘y chain loci to investigate the clonality of T lymphocytes in eight patients with T cell lymphocytosis and cytopenia (TCLC). This syndrome, which is strongly associated with rheumatoid arthritis, is characterized by peripheral blood and bone marrow lymphocytosis and neutropenia. red cell aplasia. or both. By means of T cell monoclonal antibodies and flow cytometry. T lymphocytes from patients with this syndrome have been shown to have characteristic immunologic features. Investigators have disagreed as to whether the syndrome represents a T cell malignancy or a more benign immunologic disorder. DNA from five of five

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