Role of the hippocampus in imagination and future thinking

Squire et al. (1) recently asserted that patients with bilateral hippocampal damage can imagine future experiences. This contradicts a number of previous reports where amnesia and bilateral hippocampal lesions have been found to cause significant impairment in imagining fictitious and future scenarios (2–4). Based on their findings, Squire et al. (1) concluded that the capacity for imagining the future is independent of the hippocampus. However, there are several aspects of their study that make this conclusion uncertain.