Carbonic anhydrase 2 (CAII) supports tumor blood endothelial cell survival under lactic acidosis in the tumor microenvironment

[1]  H. Lane,et al.  Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells , 2018, Cell reports.

[2]  Sean P. Palecek,et al.  Abstract 3481: Elucidating the metabolic crosstalk between lymphatic endothelial cells and breast cancer using 1H NMR metabolomics , 2018, Molecular and Cellular Biology / Genetics.

[3]  S. Pastoreková,et al.  The proteoglycan-like domain of carbonic anhydrase IX mediates non-catalytic facilitation of lactate transport in cancer cells , 2018, Oncotarget.

[4]  J. Deitmer,et al.  A surface proton antenna in carbonic anhydrase II supports lactate transport in cancer cells , 2018, eLife.

[5]  C. Supuran Carbonic Anhydrases and Metabolism , 2018, Metabolites.

[6]  Sufen Li,et al.  COX-2 inhibition in the endothelium induces glucose metabolism normalization and impairs tumor progression , 2017, Molecular medicine reports.

[7]  O. Werz,et al.  Acetyl-CoA carboxylase 1 regulates endothelial cell migration by shifting the phospholipid composition[S] , 2017, Journal of Lipid Research.

[8]  Shaghayegh Haghjooy Javanmard,et al.  Acquired tumor resistance to antiangiogenic therapy: Mechanisms at a glance , 2017, Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences.

[9]  Soon-Sun Hong,et al.  Tumor vessel normalization by the PI3K inhibitor HS-173 enhances drug delivery. , 2017, Cancer letters.

[10]  M. Shindoh,et al.  ROS enhance angiogenic properties via regulation of NRF2 in tumor endothelial cells , 2017, Oncotarget.

[11]  P. Carmeliet,et al.  Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy. , 2016, Cancer cell.

[12]  N. Demartines,et al.  Acidic pH reduces VEGF-mediated endothelial cell responses by downregulation of VEGFR-2; relevance for anti-angiogenic therapies , 2016, Oncotarget.

[13]  C. Supuran,et al.  Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines. , 2016, Bioorganic & medicinal chemistry.

[14]  Y. Ohba,et al.  Tumour endothelial cells in high metastatic tumours promote metastasis via epigenetic dysregulation of biglycan , 2016, Scientific Reports.

[15]  Yasuo Iwadate,et al.  Epithelial-mesenchymal transition in glioblastoma progression , 2016, Oncology letters.

[16]  Paweena Dana,et al.  Inhibition of carbonic anhydrase potentiates bevacizumab treatment in cholangiocarcinoma , 2016, Tumor Biology.

[17]  N. Lu,et al.  Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor , 2015, Oncotarget.

[18]  J. Mi,et al.  Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation. , 2015, Cell reports.

[19]  H. Yeger,et al.  Carbonic anhydrase II mediates malignant behavior of pulmonary neuroendocrine tumors. , 2015, American journal of respiratory cell and molecular biology.

[20]  G. Cline,et al.  Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.

[21]  Hao Wu,et al.  Beyond Warburg effect – dual metabolic nature of cancer cells , 2014, Scientific Reports.

[22]  Robert J. Gillies,et al.  pH sensing and regulation in cancer , 2013, Front. Physiol..

[23]  N. Shinohara,et al.  Lysyl oxidase secreted by tumour endothelial cells promotes angiogenesis and metastasis , 2013, British Journal of Cancer.

[24]  John L Cleveland,et al.  Targeting lactate metabolism for cancer therapeutics. , 2013, Journal of Clinical Investigation.

[25]  Mohammad Wahid Ansari,et al.  The legal status of in vitro embryos , 2014 .

[26]  Xun Hu,et al.  Central role of lactic acidosis in cancer cell resistance to glucose deprivation‐induced cell death , 2012, The Journal of pathology.

[27]  M. Dewhirst,et al.  Targeting the Lactate Transporter MCT1 in Endothelial Cells Inhibits Lactate-Induced HIF-1 Activation and Tumor Angiogenesis , 2012, PloS one.

[28]  N. Shinohara,et al.  Heterogeneity of tumor endothelial cells: comparison between tumor endothelial cells isolated from high- and low-metastatic tumors. , 2012, The American journal of pathology.

[29]  N. Inoue,et al.  Tumor endothelial cells acquire drug resistance by MDR1 up-regulation via VEGF signaling in tumor microenvironment. , 2012, The American journal of pathology.

[30]  M. Toi,et al.  Tumor Angiogenesis: Pericytes and Maturation Are Not to Be Ignored , 2011, Journal of oncology.

[31]  Pierre Sonveaux,et al.  Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis. , 2011, Cancer research.

[32]  A. Raza,et al.  Pericytes and vessel maturation during tumor angiogenesis and metastasis , 2010, American journal of hematology.

[33]  Y. Totsuka,et al.  Inhibitory effects of epigallocatechin‐3 gallate, a polyphenol in green tea, on tumor‐associated endothelial cells and endothelial progenitor cells , 2009, Cancer science.

[34]  J. Pastorek,et al.  Carbonic anhydrases in meningiomas: association of endothelial carbonic anhydrase II with aggressive tumor features. , 2009, Journal of neurosurgery.

[35]  K. Ballmer-Hofer,et al.  Structure and function of VEGF receptors , 2009, IUBMB life.

[36]  M. Tomita,et al.  Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. , 2009, Cancer research.

[37]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[38]  Julien Verrax,et al.  Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. , 2008, The Journal of clinical investigation.

[39]  Gabriele Bergers,et al.  Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.

[40]  H. Haapasalo,et al.  Carbonic anhydrase II in the endothelium of glial tumors: a potential target for therapy. , 2007, Neuro-oncology.

[41]  Gregor Rothe,et al.  Inhibitory effect of tumor cell-derived lactic acid on human T cells. , 2007, Blood.

[42]  M. O. oude Egbrink,et al.  Epigenetic regulation of tumor endothelial cell anergy: silencing of intercellular adhesion molecule-1 by histone modifications. , 2006, Cancer research.

[43]  G. Albertini,et al.  Carbonic Anhydrase II in the Developing and Adult Human Brain , 2006, Journal of neuropathology and experimental neurology.

[44]  Katsuaki Sato,et al.  Carbonic Anhydrase II Is a Tumor Vessel Endothelium–Associated Antigen Targeted by Dendritic Cell Therapy , 2005, Clinical Cancer Research.

[45]  Dhara N. Amin,et al.  Tumor-Associated Endothelial Cells with Cytogenetic Abnormalities , 2004, Cancer Research.

[46]  E. Voest,et al.  Are tumours angiogenesis‐dependent? , 2004, The Journal of pathology.

[47]  E. Piek,et al.  Pericyte production of cell-associated VEGF is differentiation-dependent and is associated with endothelial survival. , 2003, Developmental biology.

[48]  B. Alvarez,et al.  Carbonic Anhydrase II Binds to and Enhances Activity of the Na+/H+ Exchanger* , 2002, The Journal of Biological Chemistry.

[49]  R. Jain,et al.  Acidic Extracellular pH Induces Vascular Endothelial Growth Factor (VEGF) in Human Glioblastoma Cells via ERK1/2 MAPK Signaling Pathway , 2002, The Journal of Biological Chemistry.

[50]  F. Facchiano,et al.  Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression. , 2000, Circulation research.

[51]  N. Price,et al.  The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. , 1999, The Biochemical journal.

[52]  T. Teramoto The effect of extracellular pH on the adherence and differentiation of isolated rat osteoclasts , 1998 .

[53]  Atsushi Namiki,et al.  Hypoxia Induces Vascular Endothelial Growth Factor in Cultured Human Endothelial Cells (*) , 1995, The Journal of Biological Chemistry.

[54]  S. Parkkila,et al.  Immunohistochemical demonstration of human carbonic anhydrase isoenzyme II in brain tumours , 1995, The Histochemical Journal.

[55]  K. Jennbacken,et al.  Pericyte coverage decreases invasion of tumour cells into blood vessels in prostate cancer xenografts , 2009, Prostate Cancer and Prostatic Diseases.

[56]  D. West,et al.  The effect of extracellular pH on angiogenesis in vitro , 2004, Angiogenesis.

[57]  S. Parkkila,et al.  Immunohistochemical demonstration of human carbonic anhydrase isoenzyme II in brain tumours , 2004, The Histochemical Journal.

[58]  Hilde van der Togt,et al.  Publisher's Note , 2003, J. Netw. Comput. Appl..