An overview of recent developments in FLUKA PET tools.

The new developments of the FLUKA Positron-Emission-Tomography (PET) tools are detailed. FLUKA is a fully integrated Monte Carlo (MC) particle transport code, used for an extended range of applications, including Medical Physics. Recently, it provided the medical community with dedicated simulation tools for clinical applications, including the PET simulation package. PET is a well-established imaging technique in nuclear medicine, and a promising method for clinical in vivo treatment verification in hadrontherapy. The application of clinically established PET scanners to new irradiation environments such as hadrontherapy requires further experimental and theoretical research to which MC simulations could be applied. The FLUKA PET tools, besides featuring PET scanner models in its library, allow the configuration of new PET prototypes via the FLUKA Graphical User Interface (GUI) Flair. Both the beam time structure and scan time can be specified by the user, reproducing PET acquisitions in time, in a particle therapy scenario. Furthermore, different scoring routines allow the analysis of single and coincident events, and identification of parent isotopes generating annihilation events. Two reconstruction codes are currently supported: the Filtered Back-Projection (FBP) and Maximum-Likelihood Expectation Maximization (MLEM), the latter embedded in the tools. Compatibility with other reconstruction frameworks is also possible. The FLUKA PET tools package has been successfully tested for different detectors and scenarios, including conventional functional PET applications and in beam PET, either using radioactive sources, or simulating hadron beam irradiations. The results obtained so far confirm the FLUKA PET tools suitability to perform PET simulations in R&D environment.

[1]  Katia Parodi,et al.  The modelling of positron emitter production and PET imaging during carbon ion therapy , 2004, Physics in medicine and biology.

[2]  Katia Parodi,et al.  On- and off-line monitoring of ion beam treatment , 2016 .

[3]  T. Bortfeld,et al.  Correlation between CT numbers and tissue parameters needed for Monte Carlo simulations of clinical dose distributions. , 2000, Physics in medicine and biology.

[4]  Riccardo Paramatti,et al.  Monitoring of Hadrontherapy Treatments by Means of Charged Particle Detection , 2016, Front. Oncol..

[5]  Sanjiv Sam Gambhir,et al.  AMIDE: a free software tool for multimodality medical image analysis. , 2003, Molecular imaging.

[6]  Katia Parodi,et al.  PET monitoring of hadrontherapy , 2012 .

[7]  Wolfgang Enghardt,et al.  On the detector arrangement for in-beam PET for hadron therapy monitoring , 2006, Physics in medicine and biology.

[8]  Giacomo Cuttone,et al.  DoPET: an in-treatment monitoring system for proton therapy at 62 MeV , 2016 .

[9]  C. Tsoumpas,et al.  STIR: software for tomographic image reconstruction release 2 , 2012, 2006 IEEE Nuclear Science Symposium Conference Record.

[10]  P Solevi,et al.  Noise evaluation of Compton camera imaging for proton therapy , 2015, Physics in medicine and biology.

[11]  R. Paramatti,et al.  Design of a tracking device for on-line dose monitoring in hadrontherapy , 2017 .

[12]  Julia Bauer,et al.  The FLUKA Code: An Accurate Simulation Tool for Particle Therapy , 2016, Front. Oncol..

[13]  Pat Zanzonico,et al.  Positron emission tomography: a review of basic principles, scanner design and performance, and current systems. , 2004, Seminars in nuclear medicine.

[14]  Yong Hyun Chung,et al.  A simulation study of a C-shaped in-beam PET system for dose verification in carbon ion therapy , 2013 .

[15]  V. Vlachoudis,et al.  The FLUKA Code: Developments and Challenges for High Energy and Medical Applications , 2014 .

[16]  M. Bajard,et al.  Monitoring the Bragg peak location of 73 MeV/u carbon ions by means of prompt γ-ray measurements , 2008, 0809.0185.

[17]  K Parodi,et al.  Potential application of PET in quality assurance of proton therapy. , 2000, Physics in medicine and biology.

[18]  E. Hoffman,et al.  A positron-emission transaxial tomograph for nuclear imaging (PETT). , 1975, Radiology.

[19]  A. Ferrari,et al.  Describing Compton scattering and two-quanta positron annihilation based on Compton profiles: two models suited for the Monte Carlo method , 2012 .

[20]  Katia Parodi,et al.  In-beam PET measurements of β+ radioactivity induced by proton beams , 2002 .

[21]  Michel Defrise,et al.  Exact and approximate rebinning algorithms for 3-D PET data , 1997, IEEE Transactions on Medical Imaging.

[22]  Joao Seco,et al.  Proton range verification through prompt gamma-ray spectroscopy , 2014, Physics in medicine and biology.

[23]  G Sportelli,et al.  Full-beam performances of a PET detector with synchrotron therapeutic proton beams , 2016, Physics in medicine and biology.

[24]  David W Townsend,et al.  Positron emission tomography/computed tomography. , 2008, Seminars in nuclear medicine.

[25]  Katia Parodi,et al.  A systematic Monte Carlo study on the dosimetric and imaging properties of C-11 and O-15 beams , 2016 .

[26]  Hideyuki Mizuno,et al.  Spot Scanning Using Radioactive 11C Beams for Heavy-Ion Radiotherapy , 2001 .

[27]  Christopher Kurz,et al.  PET-CT scanner characterization for PET raw data use in biomedical research , 2014, Comput. Medical Imaging Graph..

[28]  Katia Parodi,et al.  Implementation and workflow for PET monitoring of therapeutic ion irradiation: a comparison of in-beam, in-room, and off-line techniques , 2011, Physics in medicine and biology.

[29]  R. Leahy,et al.  Digimouse: a 3D whole body mouse atlas from CT and cryosection data , 2007, Physics in medicine and biology.

[30]  Christopher Kurz,et al.  Clinical evaluation of 4D PET motion compensation strategies for treatment verification in ion beam therapy , 2016, Physics in medicine and biology.

[31]  Chan Hyeong Kim,et al.  Prompt gamma measurements for locating the dose falloff region in the proton therapy , 2006 .

[32]  Vlachoudis.  FLAIR: A POWERFUL BUT USER FRIENDLY GRAPHICAL INTERFACE FOR FLUKA , 2009 .

[33]  K. Parodi,et al.  The feasibility of in-beam PET for accurate monitoring of proton therapy: results of a comprehensive experimental study , 2004, IEEE Symposium Conference Record Nuclear Science 2004..

[34]  C. A. Tobias,et al.  Radioactive fragmentation of N7+ ion beam observed in a beryllium target , 1971 .

[35]  R. Wilson.  Radiological use of fast protons. , 1946, Radiology.

[36]  W. Enghardt,et al.  Direct time-of-flight for quantitative, real-time in-beam PET: a concept and feasibility study , 2007, Physics in medicine and biology.

[37]  C A Tobias,et al.  High energy beams of radioactive nuclei and their biomedical applications. , 1981, International journal of radiation oncology, biology, physics.

[38]  Eiji Yoshida,et al.  A proposal of an open PET geometry , 2008, Physics in medicine and biology.

[39]  T Yamaya.  OpenPET: a novel open-type PET system for 3D dose verification in particle therapy , 2017 .