Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition.
暂无分享,去创建一个
Chenqi Xu | Jiawei Shi | J. Lou | B. Evavold | Peng Wu | Tongtong Zhang | Baoyu Liu | Panyu Fei | L. Cui | Rui Qin | Huaying Zhu | Danmei Yao | R. Martinez | Wei Hu | Chenyi An | Yong Zhang | Junwei Liu | Juan Fan | Weiwei Yin | Jie Sun | Chun Zhou | Xun Zeng | Jian'an Wang | Wei Chen | C. Zhu
[1] E. Reinherz,et al. The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations , 2018 .
[2] K. Salaita,et al. A TCR mechanotransduction signaling loop induces negative selection in the thymus , 2018, Nature Immunology.
[3] E. Reinherz,et al. The T Cell Antigen Receptor &agr; Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations , 2018, Immunity.
[4] William A. Goddard,et al. Isolation of a Structural Mechanism for Uncoupling T Cell Receptor Signaling from Peptide-MHC Binding , 2018, Cell.
[5] Gerhard J Schütz,et al. The TCR is randomly distributed on the plasma membrane of resting antigen-experienced T cells , 2018, Nature Immunology.
[6] M. Brameshuber,et al. Monomeric TCRs drive T cell antigen recognition , 2018, Nature Immunology.
[7] M. Berger,et al. Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy , 2018, Science.
[8] M. Huse. Mechanical forces in the immune system , 2017, Nature Reviews Immunology.
[9] J. Kuriyan,et al. A Phosphosite within the SH2 Domain of Lck Regulates Its Activation by CD45. , 2017, Molecular cell.
[10] Peter Schuck,et al. An allosteric site in the T-cell receptor Cβ domain plays a critical signalling role , 2017, Nature Communications.
[11] Frederic Bartumeus,et al. Visualizing dynamic microvillar search and stabilization during ligand detection by T cells , 2017, Science.
[12] C. Goudot,et al. Different TCR-induced T lymphocyte responses are potentiated by stiffness with variable sensitivity , 2017, eLife.
[13] E. Reinherz,et al. Pre-T Cell Receptors (Pre-TCRs) Leverage Vβ Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands*♦ , 2016, The Journal of Biological Chemistry.
[14] R. Alon,et al. Three-dimensional localization of T-cell receptors in relation to microvilli using a combination of superresolution microscopies , 2016, Proceedings of the National Academy of Sciences.
[15] Jie Yan,et al. The mechanical response of talin , 2016, Nature Communications.
[16] M. Butte,et al. T cell activation requires force generation , 2016, The Journal of cell biology.
[17] Yang Liu,et al. DNA-based nanoparticle tension sensors reveal that T-cell receptors transmit defined pN forces to their antigens for enhanced fidelity , 2016, Proceedings of the National Academy of Sciences.
[18] V. Nadarajah,et al. Structural Model of the Extracellular Assembly of the TCR-CD3 Complex. , 2016, Cell reports.
[19] Weiyang Jin,et al. Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing , 2016, Cell.
[20] D. Klenerman,et al. Initiation of T cell signaling by CD45 segregation at ‘close-contacts’ , 2016, Nature Immunology.
[21] K. Cibulskis,et al. Comprehensive analysis of cancer-associated somatic mutations in class I HLA genes , 2015, Nature Biotechnology.
[22] P. Allen,et al. Force-Regulated In Situ TCR–Peptide-Bound MHC Class II Kinetics Determine Functions of CD4+ T Cells , 2015, The Journal of Immunology.
[23] Hang Lu,et al. Pre-TCR ligand binding impacts thymocyte development before αβTCR expression , 2015, Proceedings of the National Academy of Sciences.
[24] James McCluskey,et al. T cell antigen receptor recognition of antigen-presenting molecules. , 2015, Annual review of immunology.
[25] Gerhard Wagner,et al. Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime , 2015, Proceedings of the National Academy of Sciences.
[26] Omer Dushek,et al. Phenotypic models of T cell activation , 2014, Nature Reviews Immunology.
[27] Cheng Zhu,et al. Accumulation of Dynamic Catch Bonds between TCR and Agonist Peptide-MHC Triggers T Cell Signaling , 2014, Cell.
[28] Lance C Kam,et al. CD28 and CD3 have complementary roles in T-cell traction forces , 2014, Proceedings of the National Academy of Sciences.
[29] Mark M Davis,et al. A single peptide-major histocompatibility complex ligand triggers digital cytokine secretion in CD4(+) T cells. , 2013, Immunity.
[30] Cees Dekker,et al. Non-bias-limited tracking of spherical particles, enabling nanometer resolution at low magnification. , 2012, Biophysical journal.
[31] Wayne W. Hancock,et al. Substrate Rigidity Regulates Human T Cell Activation and Proliferation , 2012, The Journal of Immunology.
[32] Michael L. Dustin,et al. New insights into the T cell synapse from single molecule techniques , 2011, Nature Reviews Immunology.
[33] Jie Yan,et al. Improved high-force magnetic tweezers for stretching and refolding of proteins and short DNA. , 2011, Biophysical journal.
[34] Cheng Zhu,et al. The kinetics of two dimensional TCR and pMHC interactions determine T cell responsiveness , 2010, Nature.
[35] Evan W. Newell,et al. TCR–peptide–MHC interactions in situ show accelerated kinetics and increased affinity , 2010, Nature.
[36] Raibatak Das,et al. A Role for Rebinding in Rapid and Reliable T Cell Responses to Antigen , 2009, PLoS Comput. Biol..
[37] E. Reinherz,et al. The αβ T Cell Receptor Is an Anisotropic Mechanosensor* , 2009, The Journal of Biological Chemistry.
[38] V. Zarnitsyna,et al. Measuring Receptor–Ligand Binding Kinetics on Cell Surfaces: From Adhesion Frequency to Thermal Fluctuation Methods , 2008, Cellular and molecular bioengineering.
[39] Etienne Gagnon,et al. Regulation of T Cell Receptor Activation by Dynamic Membrane Binding of the CD3ɛ Cytoplasmic Tyrosine-Based Motif , 2008, Cell.
[40] Zhengyu Ma,et al. Surface-Anchored Monomeric Agonist pMHCs Alone Trigger TCR with High Sensitivity , 2008, PLoS biology.
[41] Simon J Davis,et al. The kinetic-segregation model: TCR triggering and beyond , 2006, Nature Immunology.
[42] Yi Li,et al. Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide‐MHC without increasing apparent cross‐reactivity , 2006, Protein science : a publication of the Protein Society.
[43] Robyn L Stanfield,et al. How TCRs bind MHCs, peptides, and coreceptors. , 2006, Annual review of immunology.
[44] Laxmikant V. Kalé,et al. Scalable molecular dynamics with NAMD , 2005, J. Comput. Chem..
[45] P. A. van der Merwe,et al. T-cell receptor triggering is critically dependent on the dimensions of its peptide-MHC ligand , 2005, Nature.
[46] Andrew Sewell,et al. Structural and kinetic basis for heightened immunogenicity of T cell vaccines , 2005, The Journal of experimental medicine.
[47] Conrad C. Huang,et al. UCSF Chimera—A visualization system for exploratory research and analysis , 2004, J. Comput. Chem..
[48] András Fiser,et al. ModLoop: automated modeling of loops in protein structures , 2003, Bioinform..
[49] K. Garcia,et al. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. , 2000, Immunity.
[50] S. Bromley,et al. The immunological synapse: a molecular machine controlling T cell activation. , 1999, Science.
[51] Alexander D. MacKerell,et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. , 1998, The journal of physical chemistry. B.
[52] L R Pease,et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. , 1998, Science.
[53] Partho Ghosh,et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2 , 1996, Nature.
[54] K Schulten,et al. VMD: visual molecular dynamics. , 1996, Journal of molecular graphics.
[55] R. Germain,et al. Peptide and beta 2-microglobulin regulation of cell surface MHC class I conformation and expression. , 1992, Journal of immunology.
[56] D. Wiley,et al. HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[57] Omer Dushek,et al. Mechanisms for T cell receptor triggering , 2011, Nature Reviews Immunology.