Isotonic crystalline amino acids for protein sparing

The formulation of a theory based on models that can be tested and modified accordingly has proved to be a style of reasoning that has provided science with its most spectacular successes. Its power lies in its flexibility to conform to successive revelations that the data may provide. As a postulation-deduction method, hypothesis is never safe, is always tried, and it either matures into formal theory or is soon discarded. The scientific method that has its roots in Descartes and Newton has as its strength and weakness the aspect that only those hypotheses that can be tested by objective reproducible measurements are of value. Those hypotheses that cannot be so tested are not scientific in the strict sense of the word. Hence the hypothesis is the single most creative step in the reductionist process and any logical method, no matter how powerful, is useless without it. From this it is understood that a hypothesis is more sharply defined by its falsifiability. Blackburn and Flatt’s hypothesis1–4 concerning energy substrate regulation is eminently falsifiable because of the specific qualitative and quantitative predictions it makes about substrate concentrations and clinical events5–7.

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