Some Results on more Flexible Versions of Graph Motif

The problems studied in this paper originate from Graph Motif, a problem introduced in 2006 in the context of biological networks. Informally speaking, it consists in deciding if a multiset of colors occurs in a connected subgraph of a vertex-colored graph. Due to the high rate of noise in the biological data, more flexible definitions of the problem have been outlined. We present in this paper two inapproximability results for two different optimization variants of Graph Motif. We also study another definition of the problem, when the connectivity constraint is replaced by modularity. While the problem stays NP-complete, it allows algorithms in FPT for biologically relevant parameterizations.

[1]  Riccardo Dondi,et al.  Finding Approximate and Constrained Motifs in Graphs , 2011, CPM.

[2]  Gary D Bader,et al.  The Genetic Landscape of a Cell , 2010, Science.

[3]  Julien Gagneur,et al.  Modular decomposition of protein-protein interaction networks , 2004, Genome Biology.

[4]  Roded Sharan,et al.  Topology-Free Querying of Protein Interaction Networks , 2009, RECOMB.

[5]  D. Pe’er,et al.  Module networks: identifying regulatory modules and their condition-specific regulators from gene expression data , 2003, Nature Genetics.

[6]  Sylvain Guillemot,et al.  Finding and Counting Vertex-Colored Subtrees , 2010, Algorithmica.

[7]  A. Barabasi,et al.  Hierarchical Organization of Modularity in Metabolic Networks , 2002, Science.

[8]  Michael R. Fellows,et al.  Sharp Tractability Borderlines for Finding Connected Motifs in Vertex-Colored Graphs , 2007, ICALP.

[9]  Cristina G. Fernandes,et al.  Motif Search in Graphs: Application to Metabolic Networks , 2006, IEEE/ACM Transactions on Computational Biology and Bioinformatics.

[10]  Florian Rasche,et al.  Annotating Fragmentation Patterns , 2009, WABI.

[11]  David Zuckerman Linear Degree Extractors and the Inapproximability of Max Clique and Chromatic Number , 2007, Theory Comput..

[12]  T. Ideker,et al.  Modeling cellular machinery through biological network comparison , 2006, Nature Biotechnology.

[13]  Geevarghese Philip,et al.  On the Kernelization Complexity of Colorful Motifs , 2010, IPEC.

[14]  Michel Habib,et al.  Partitive hypergraphs , 1981, Discret. Math..

[15]  Christian Komusiewicz,et al.  Parameterized Algorithms and Hardness Results for Some Graph Motif Problems , 2008, CPM.

[16]  Mark Gerstein,et al.  Bridging structural biology and genomics: assessing protein interaction data with known complexes. , 2002, Drug discovery today.

[17]  Riccardo Dondi,et al.  Complexity issues in vertex-colored graph pattern matching , 2011, J. Discrete Algorithms.

[18]  Ran Raz,et al.  A sub-constant error-probability low-degree test, and a sub-constant error-probability PCP characterization of NP , 1997, STOC '97.

[19]  Michel Habib,et al.  A Simple Linear-Time Modular Decomposition Algorithm for Graphs, Using Order Extension , 2004, SWAT.

[20]  Ryan Williams,et al.  Limits and Applications of Group Algebras for Parameterized Problems , 2009, ICALP.