Aromatic hydrocarbons and risk of skin cancer by anatomical site in 25 000 male offshore petroleum workers

BACKGROUND We prospectively examined skin cancer risk according to occupational exposure to aromatic hydrocarbons with adjustment for ultraviolet radiation exposure, in a cohort of 24 917 male offshore petroleum workers. METHODS Hazard ratios (HRs) and 95% confidence intervals were estimated with Cox regression adapted to a stratified case-cohort design. RESULTS During 13.5 years of follow-up, 112 cutaneous melanomas (CMs) and 70 non-melanoma skin cancers were identified. Increased risks of CM and of squamous cell carcinoma on the forearm and hand were seen among those ever exposed to crude oil or benzene. For skin cancers of the forearm and hand combined, cumulative and duration metrics of benzene exposure showed Ptrends of 0.031 and 0.003, respectively. CONCLUSIONS Our results support an association between exposure to crude oil or benzene and skin cancer risk on hands and forearms among offshore petroleum workers. Dermal uptake of polycyclic aromatic hydrocarbons or benzene may explain this association.

[1]  T. Grimsrud,et al.  Aromatic hydrocarbons and risk of skin cancer by anatomical site in 25 000 male offshore petroleum workers , 2017, American journal of industrial medicine.

[2]  Tim K. Lee,et al.  Melanoma Epidemiology and Prevention. , 2016, Cancer treatment and research.

[3]  N. Rothman,et al.  Benzene exposure and risk of lymphohaematopoietic cancers in 25 000 offshore oil industry workers , 2015, British Journal of Cancer.

[4]  Magne Bråtveit,et al.  Self-reported Occupational Exposures Relevant for Cancer among 28,000 Offshore Oil Industry Workers Employed between 1965 and 1999 , 2015, Journal of occupational and environmental hygiene.

[5]  M. Veierød,et al.  Cutaneous squamous cell carcinoma in norway 1963–2011: increasing incidence and stable mortality , 2015, Cancer medicine.

[6]  T. Grimsrud,et al.  Cancer incidence among 41,000 offshore oil industry workers. , 2014, Occupational medicine.

[7]  K. Bogen,et al.  Dermal Versus Total Uptake of Benzene from Mineral Spirits Solvent During Parts Washing , 2014, Risk analysis : an official publication of the Society for Risk Analysis.

[8]  B. Møller,et al.  Sex differences in rising trends of cutaneous malignant melanoma in Norway, 1954–2008 , 2013, Melanoma research.

[9]  M. Sydnes,et al.  Polycyclic Aromatic Hydrocarbons a Constituent of Petroleum: Presence and Influence in the Aquatic Environment , 2013 .

[10]  J. Lortet-Tieulent,et al.  International trends in the incidence of malignant melanoma 1953–2008—are recent generations at higher or lower risk? , 2013, International journal of cancer.

[11]  J. Leonardi-Bee,et al.  A systematic review of worldwide incidence of nonmelanoma skin cancer , 2012, The British journal of dermatology.

[12]  B. Hollund,et al.  Supplementary information to the Job Exposure Matrix for benzene, asbestos and oil mist/oil vapour among Norwegian offshore workers , 2012 .

[13]  Chemical agents and related occupations. , 2012, IARC monographs on the evaluation of carcinogenic risks to humans.

[14]  D. Christiani,et al.  Metalworking Fluids and Malignant Melanoma in Autoworkers , 2011, Epidemiology.

[15]  Jacques Ferlay,et al.  NORDCAN – a Nordic tool for cancer information, planning, quality control and research , 2010, Acta oncologica.

[16]  S. Burchiel,et al.  Some non-heterocyclic polycyclic aromatic hydrocarbons and some related exposures. , 2010, IARC monographs on the evaluation of carcinogenic risks to humans.

[17]  K. Subbaramaiah,et al.  UVR Exposure Sensitizes Keratinocytes to DNA Adduct Formation , 2009, Cancer Prevention Research.

[18]  Bjørn Møller,et al.  Data quality at the Cancer Registry of Norway: an overview of comparability, completeness, validity and timeliness. , 2009, European journal of cancer.

[19]  Hans Kromhout,et al.  Expert assessment of exposure to carcinogens in Norway's offshore petroleum industry , 2008, Journal of Exposure Science and Environmental Epidemiology.

[20]  Magne Bråtveit,et al.  Biological monitoring of benzene exposure for process operators during ordinary activity in the upstream petroleum industry. , 2007, The Annals of occupational hygiene.

[21]  T. Sorahan.  Mortality of UK oil refinery and petroleum distribution workers, 1951-2003. , 2007, Occupational medicine.

[22]  H. Kromhout,et al.  Inter-rater agreement in the assessment of exposure to carcinogens in the offshore petroleum industry , 2007, Occupational and Environmental Medicine.

[23]  Magne Bråtveit,et al.  Exposure to carcinogens for defined job categories in Norway’s offshore petroleum industry, 1970 to 2005 , 2006, Occupational and Environmental Medicine.

[24]  Y. Ibuki,et al.  Coexposure to benzo[a]pyrene and UVA induces DNA damage: First proof of double‐strand breaks in a cell‐free system , 2006, Environmental and molecular mutagenesis.

[25]  H. Morgenstern,et al.  Estimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workers. , 2005, American journal of industrial medicine.

[26]  M. Koike,et al.  Coexposure to benzo[a]pyrene plus UVA induced DNA double strand breaks: visualization of Ku assembly in the nucleus having DNA lesions. , 2004, Biochemical and biophysical research communications.

[27]  Ron Gardner,et al.  Overview and characteristics of some occupational exposures and health risks on offshore oil and gas installations. , 2003, The Annals of occupational hygiene.

[28]  Bryan Langholz,et al.  Exposure Stratified Case-Cohort Designs , 2000, Lifetime data analysis.

[29]  D. Ball,et al.  Dermal Carcinogenicity in Transgenic Mice: Relative Responsiveness of Male and Female Hemizygous and Homozygous Tg.AC Mice to 12-O-Tetradecanoylphorbol 13-Acetate (TPA) and Benzene , 1998, Toxicologic pathology.

[30]  R. Tennant,et al.  Hemizygous Tg.AC transgenic mouse as a potential alternative to the two‐year mouse carcinogenicity bioassay: evaluation of husbandry and housing factors , 1998, Journal of applied toxicology : JAT.

[31]  P. Infante,et al.  State of the science on the carcinogenicity of gasoline with particular reference to cohort mortality study results. , 1993, Environmental health perspectives.

[32]  A R Schnatter,et al.  A retrospective mortality study within operating segments of a petroleum company. , 1992, American journal of industrial medicine.

[33]  B. Järvholm,et al.  Models for skin tumour risks in workers exposed to mineral oils. , 1990, British Journal of Cancer.

[34]  J K Haseman,et al.  Multiple-site carcinogenicity of benzene in Fischer 344 rats and B6C3F1 mice. , 1989, Environmental health perspectives.

[35]  B. Conti,et al.  Benzene, an experimental multipotential carcinogen: results of the long-term bioassays performed at the Bologna Institute of Oncology. , 1989, Environmental health perspectives.

[36]  B. Järvholm,et al.  Exposure to cutting oils and its relation to skin tumors and premalignant skin lesions on the hands and forearms. , 1985, Scandinavian journal of work, environment & health.

[37]  J. Burg,et al.  Percutaneous penetration of benzene in hairless mice: an estimate of dermal absorption during tire-building operations. , 1985, American journal of industrial medicine.

[38]  Polynuclear aromatic hydrocarbons, Part 2, Carbon blacks, mineral oils (lubricant base oils and derived products) and some nitroarenes. , 1984, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.

[39]  H A Waldron,et al.  A brief history of scrotal cancer. , 1983, British journal of industrial medicine.

[40]  Some industrial chemicals and dyestuffs. , 1982, IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans.

[41]  M. Aksoy,et al.  AIDS and renal failure. , 1987, The New England journal of medicine.

[42]  M. Aksoy,et al.  Leukemia in shoe-workers exposed chronically to benzene. , 1974, Blood.

[43]  E. Mastromatteo.  CUTTING OILS AND SQUAMOUS-CELL CARCINOMA: PART I: INCIDENCE IN A PLANT WITH A REPORT OF SIX CASES , 1955 .

[44]  C. Cruickshank,et al.  Skin Cancer of the Hand and Forearm , 1952, British journal of industrial medicine.

[45]  Revised Recommendation for an Occupational Exposure Standard for-Benzene , 2022 .