论文信息 - Effect of plasma protein and tissue binding on the biologic half‐life of drugs

Effect of plasma protein and tissue binding on the biologic half‐life of drugs

It is now generally appreciated that there can be pronounced interindividual differences in plasma protein binding of many drugs because of genetic,13 environmental (drug interaction),11 and pathologic7 factors and aging.1 Pharmacokinetic theory has been developed to relate quantitatively the effect of changes in plasma protein binding to changes in the elimination kinetics of drugs.8,14 In the case of drugs that are eliminated almost entirely by hepatic biotransformation with linear (apparently nonsaturable) kinetics not limited by organ perfusion rate, it has been shown that the total clearance (Cl) is directly proportional to the free fraction of drug in plasma (fp), i.e.,

P. McNamara | M. Gibaldi | G. Levy

[1] G. Wilding,et al. Genetic control of interindividual variations in racemic warfarin binding to plasma and albumin of twins , 1977, Clinical pharmacology and therapeutics.

[2] J. Hull,et al. The Effect of Disease States on Drug Pharmacokinetics , 1977 .

[3] A. Yacobi,et al. Comparative pharmacokinetics of coumarin anticoagulants. XIV: relationship between protein binding, distribution, and elimination kinetics of warfarin in rats. , 1975, Journal of pharmaceutical sciences.

[4] Grant R. Wilkinson,et al. A physiological approach to hepatic drug clearance , 1975 .

[5] R. Gugler,et al. Pharmacokinetics of drugs in patients with the nephrotic syndrome. , 1975, The Journal of clinical investigation.

[6] A. Yacobi,et al. Letter: Effect of plasma protein binding on elimination of warfarin. , 1974, Journal of pharmaceutical sciences.

[7] J. Gillette. FACTORS AFFECTING DRUG METABOLISM , 1971, Annals of the New York Academy of Sciences.

[8] J. Wagner,et al. Blood Levels of Drug at the Equilibrium State after Multiple Dosing , 1965, Nature.

[9] A Yacobi,et al. Comparative pharmacokinetics of coumarin anticoagulants XXXI: Effect of plasma protein binding on distribution kinetics of dicumarol in rats. , 1977, Journal of pharmaceutical sciences.