Purification and characterization of a protein-tyrosine kinase encoded by the Abelson murine leukemia virus.

[1]  D. Baltimore,et al.  Localization of tyrosine kinase-coding region in v-abl oncogene by the expression of v-abl-encoded proteins in bacteria. , 1985, The Journal of biological chemistry.

[2]  D. Baltimore,et al.  Phosphorylation of ribosomal protein S6 on serine after microinjection of the Abelson murine leukemia virus tyrosine-specific protein kinase into Xenopus oocytes. , 1985, Proceedings of the National Academy of Sciences of the United States of America.

[3]  N. Rosenberg,et al.  A membrane-associated, carbohydrate-modified form of the v-abl protein that cannot be phosphorylated in vivo or in vitro , 1984, Journal of virology.

[4]  E. Krebs,et al.  A comparison of the insulin- and epidermal growth factor-stimulated protein kinases from human placenta. , 1984, Journal of Biological Chemistry.

[5]  M. Waterfield,et al.  Monoclonal antibodies against the human epidermal growth factor receptor from A431 cells. Isolation, characterization, and use in the purification of active epidermal growth factor receptor. , 1984, The Journal of biological chemistry.

[6]  T. Wong,et al.  Purification and characterization of the major species of tyrosine protein kinase in rat liver. , 1984, The Journal of biological chemistry.

[7]  R. Davis,et al.  Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity , 1984, Journal of virology.

[8]  Jonathan A. Cooper,et al.  Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. , 1984, The Journal of biological chemistry.

[9]  L. Williams,et al.  Evidence for the platelet-derived growth factor-stimulated tyrosine phosphorylation of the platelet-derived growth factor receptor in vivo. Immunopurification using a monoclonal antibody to phosphotyrosine. , 1984, The Journal of biological chemistry.

[10]  O. Rosen,et al.  Insulin receptor is an insulin-dependent tyrosine protein kinase: copurification of insulin-binding activity and protein kinase activity to homogeneity from human placenta. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[11]  G. Marinetti,et al.  Transforming protein of avian sarcoma virus UR2 is associated with phosphatidylinositol kinase activity: possible role in tumorigenesis. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[12]  B. Mroczkowski,et al.  ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA , 1984, Nature.

[13]  R. Osathanondh,et al.  Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor. , 1984, The Journal of biological chemistry.

[14]  M. Czech,et al.  Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity. , 1984, The Journal of biological chemistry.

[15]  J. Brugge,et al.  Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins. , 1984, The Journal of biological chemistry.

[16]  L. Cantley,et al.  Evidence that the Rous sarcoma virus transforming gene product phosphorylates phosphatidylinositol and diacylglycerol. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[17]  T. Wong,et al.  Kinetics and mechanism of angiotensin phosphorylation by the transforming gene product of Rous sarcoma virus. , 1984, The Journal of biological chemistry.

[18]  A. Schultz,et al.  Myristylation of gag-onc fusion proteins in mammalian transforming retroviruses. , 1984, Virology.

[19]  C. Kahn,et al.  Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells. , 1984, The Journal of biological chemistry.

[20]  E. Krebs,et al.  The use of synthetic peptides for defining the specificity of tyrosine protein kinases. , 1984, Advances in enzyme regulation.

[21]  E. Racker,et al.  A rapid assay for protein kinases phosphorylating small polypeptides and other substrates. , 1983, Analytical biochemistry.

[22]  C. Kahn,et al.  Characterization of the insulin receptor kinase purified from human placental membranes. , 1983, The Journal of biological chemistry.

[23]  M. Collett,et al.  Increase in the phosphotransferase specific activity of purified Rous sarcoma virus pp60v-src protein after incubation with ATP plus Mg2+ , 1983, Molecular and cellular biology.

[24]  D. Baltimore,et al.  Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation , 1983, Cell.

[25]  P. Cuatrecasas,et al.  Somatomedin-C stimulates the phosphorylation of the beta-subunit of its own receptor. , 1983, The Journal of biological chemistry.

[26]  A. Ross,et al.  Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells , 1983, Molecular and cellular biology.

[27]  M. Collett,et al.  Physical modification of purified Rous sarcoma virus pp60v-src protein after incubation with ATP/Mg2+. , 1983, Virology.

[28]  O. Rosen,et al.  Phosphorylation of exogenous substrates by the insulin receptor-associated protein kinase. , 1983, The Journal of biological chemistry.

[29]  M. Cobb,et al.  Phosphorylation activates the insulin receptor tyrosine protein kinase. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[30]  R. Erikson,et al.  Characterization of the Rous sarcoma virus transforming gene product. , 1983, The Journal of biological chemistry.

[31]  D. Garbers,et al.  The kinetics of tyrosine phosphorylation by the purified epidermal growth factor receptor kinase of A-431 cells. , 1983, The Journal of biological chemistry.

[32]  C. Kahn,et al.  Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[33]  F. Lipmann,et al.  Reversal of Rous sarcoma-specific immunoglobulin phosphorylation on tyrosine (ADP as phosphate acceptor) catalyzed by the src gene kinase. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[34]  T. Wong,et al.  In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases. , 1983, The Journal of biological chemistry.

[35]  C. Kahn,et al.  Characterization of insulin-mediated phosphorylation of the insulin receptor in a cell-free system. , 1983, The Journal of biological chemistry.

[36]  H. Krutzsch,et al.  Myristyl amino-terminal acylation of murine retrovirus proteins: an unusual post-translational proteins modification. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[37]  T. Hunter,et al.  Regulation of cell growth and transformation by tyrosine-specific protein kinases: the search for important cellular substrate proteins. , 1983, Current topics in microbiology and immunology.

[38]  J. Bishop.  Cellular oncogenes and retroviruses. , 1983, Annual review of biochemistry.

[39]  J. Foulkes,et al.  Phosphotyrosyl-protein phosphatases. , 1983, Current topics in microbiology and immunology.

[40]  P. Pilch,et al.  Stimulation of tyrosine-specific phosphorylation in vitro by insulin-like growth factor I , 1983, Nature.

[41]  A. Kahn,et al.  High tyrosine kinase activity in normal nonproliferating cells , 1983, Nature.

[42]  R. Osathanondh,et al.  Insulin-stimulated tyrosine phosphorylation of the insulin receptor in detergent extracts of human placental membranes. Comparison to epidermal growth factor-stimulated phosphorylation. , 1982, The Journal of biological chemistry.

[43]  J. Stephenson,et al.  Abelson murine leukemia virus P120: identification and characterization of tyrosine phosphorylation sites , 1982, Journal of virology.

[44]  D. Baltimore,et al.  Expression of an Abelson murine leukemia virus-encoded protein in Escherichia coli causes extensive phosphorylation of tyrosine residues. , 1982, The Journal of biological chemistry.

[45]  Y. Nishizuka,et al.  Calcium-activated, phospholipid-dependent protein kinase from rat brain. Subcellular distribution, purification, and properties. , 1982, The Journal of biological chemistry.

[46]  C. Heldin,et al.  Characterization of a tyrosine-specific kinase activity in human fibroblast membranes stimulated by platelet-derived growth factor. , 1982, The Journal of biological chemistry.

[47]  C. Kahn,et al.  Insulin stimulates tyrosine phosphorylation of the insulin receptor in a cell-free system , 1982, Nature.

[48]  T. Hunter,et al.  Two structurally and functionally different forms of the transforming protein of PRC II avian sarcoma virus , 1982, Molecular and cellular biology.

[49]  N. Rosenberg,et al.  In vivo tyrosine phosphorylations of the abelson virus transforming protein are absent in its normal cellular homolog , 1982, Cell.

[50]  I. Pastan,et al.  Properties of the src kinase purified from Rous sarcoma virus-induced rat tumors. , 1982, Journal of Biological Chemistry.

[51]  T. Hunter.  Synthetic peptide substrates for a tyrosine protein kinase. , 1982, The Journal of biological chemistry.

[52]  H. Hanafusa,et al.  Avian sarcoma virus UR2 encodes a transforming protein which is associated with a unique protein kinase activity , 1982, Journal of virology.

[53]  E. Krebs,et al.  Epidermal growth factor stimulates the phosphorylation of synthetic tyrosine-containing peptides by A431 cell membranes. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[54]  Michael Chinkers,et al.  A native 170,000 epidermal growth factor receptor-kinase complex from shed plasma membrane vesicles. , 1982, The Journal of biological chemistry.

[55]  A. Levinson,et al.  Bacterial expression of an enzymatically active protein encoded by RSV src gene , 1982, Nature.

[56]  H. Snyder,et al.  Biochemical characterization of protein kinase activities associated with transforming gene products of the Snyder-Theilen and Gardner-Arnstein strains of feline sarcoma virus. , 1982, Virology.

[57]  J. Corbin,et al.  Regulatory mechanisms in the control of protein kinases. , 1982, CRC critical reviews in biochemistry.

[58]  Jonathan A. Cooper,et al.  Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[59]  E. Krebs,et al.  Phosphorylation of synthetic peptides by a tyrosine protein kinase from the particulate fraction of a lymphoma cell line. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[60]  T. Gilmer,et al.  Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase , 1981, Nature.

[61]  C. Merril,et al.  Ultrasensitive stain for proteins in polyacrylamide gels shows regional variation in cerebrospinal fluid proteins. , 1981, Science.

[62]  A. Levinson,et al.  Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src). , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[63]  T. Hunter,et al.  Evidence that the Abelson virus protein functions in vivo as a protein kinase that phosphorylates tyrosine. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[64]  S. Cohen,et al.  Identification of phosphotyrosine as a product of epidermal growth factor-activated protein kinase in A-431 cell membranes. , 1980, The Journal of biological chemistry.

[65]  D. Baltimore,et al.  A transformation-defective mutant of Abelson murine leukemia virus lacks protein kinase activity. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[66]  T. Hunter,et al.  Transforming gene product of Rous sarcoma virus phosphorylates tyrosine , 1980, Proceedings of the National Academy of Sciences.

[67]  D. Baltimore,et al.  Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine , 1980, Nature.

[68]  P. Cohen,et al.  Molecular aspects of cellular regulation , 1980 .

[69]  D. Baltimore,et al.  Preparation of syngeneic tumor regressor serum reactive with the unique determinants of the Abelson murine leukemia virus-encoded P120 protein at the cell surface , 1979, Journal of virology.

[70]  G. Carpenter,et al.  Rapid enhancement of protein phosphorylation in A-431 cell membrane preparations by epidermal growth factor. , 1979, The Journal of biological chemistry.

[71]  E. Kaiser,et al.  Cyclic AMP-dependent ATPase activity of bovine heart protein kinase. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[72]  A. Cornish-Bowden,et al.  Evaluation of distribution-free confidence limits for enzyme kinetic parameters. , 1978, Journal of theoretical biology.

[73]  D. Graves,et al.  Studies on the specificity of phosphorylase kinase using peptide substrates. , 1977, The Journal of biological chemistry.

[74]  E. Krebs,et al.  Reversibility of phosphorylase kinase reaction. , 1977, The Journal of biological chemistry.

[75]  E. Krebs,et al.  Purification and characterization of catalytic subunit of skeletal muscle adenosine 3':5'-monophosphate-dependent protein kinase. , 1977, The Journal of biological chemistry.

[76]  A. Leslie,et al.  Purification and characterization of the catalytic subunit of adenosine 3':5'-cyclic monophosphate-dependent protein kinase from bovine liver. , 1976, The Biochemical journal.

[77]  M. M. Bradford.  A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. , 1976, Analytical biochemistry.

[78]  E. Krebs,et al.  Reversibility of adenosine 3':5'-monophosphate-dependent protein kinase reactions. , 1975, The Journal of biological chemistry.

[79]  A. Cornish-Bowden,et al.  The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters. , 1974, The Biochemical journal.

[80]  U. K. Laemmli,et al.  Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4 , 1970, Nature.

[81]  G. N. Wilkinson.  Statistical estimations in enzyme kinetics. , 1961, The Biochemical journal.