Glutamate mGlu5-adenosine A2A-dopamine D2 receptor interactions in the striatum. Implications for drug therapy in neuro-psychiatric disorders and drug abuse

Chloroquine (CQ) resistance is a serious problem afflicting the populations in the Third World countries where malaria is endemic. Some strategies have been developed to circumvent the increasing spread of CQ resistance and the alarming emergence of multidrug resistance in malaria. Among these, drug combination has received much attention in the past few years. In this approach, the sensibility of resistant malaria parasites to antimalarial drugs can be restored by coadministration of one of the drugs collectively named reversing agents or chemosensitizers. The present review gives a update of chemically synthetized and naturally occuring reversing agents that have been proved to potentiate in vitro and/or in vivo the effect of the existing antimalarial drugs

[1]  F. Ciruela,et al.  Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes , 1996, Journal of neurochemistry.

[2]  B. Cronstein,et al.  Adenosine, a cytoprotective autocoid: effects of adenosine on neutrophil plasma membrane viscosity and chemoattractant receptor display. , 1989, Biochimica et biophysica acta.

[3]  J. Mallol,et al.  Adenosine Receptors in Myelin Fractions and Subtractions: The Effect of the Agonist (R)‐Phenylisopropyladenosine on Myelin Membrane Microviscosity , 1991, Journal of neurochemistry.

[4]  J. Phillis,et al.  Specific binding of 2-[3H]chloroadenosine to rat brain cortical membranes. , 1980, Canadian journal of physiology and pharmacology.

[5]  D. F. Waugh,et al.  Protein-protein interactions. , 1954, Advances in protein chemistry.

[6]  J. Phillis,et al.  Adenosine receptors in rat brain membranes: characterization of high affinity binding of [3H]-2-chloroadenosine. , 1982, The International journal of biochemistry.

[7]  I Biaggioni,et al.  Adenosine A2B receptors. , 1997, Pharmacological reviews.

[8]  M. Williams,et al.  High affinity binding of 2-chloroadenosine to rat brain synaptic membranes. , 1980, European journal of pharmacology.

[9]  F. Ciruela,et al.  The cluster-arranged cooperative model: a model that accounts for the kinetics of binding to A1 adenosine receptors. , 1996, Biochemistry.

[10]  F A Quiocho,et al.  Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations. , 1991, Science.

[11]  M. Williams,et al.  Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[12]  F. Ciruela,et al.  Ligand-induced phosphorylation, clustering, and desensitization of A1 adenosine receptors. , 1997, Molecular pharmacology.