Interleukin‐6 and soluble interleukin‐6 receptor in the colonic mucosa of inflammatory bowel disease

Background : Interleukin‐6 (IL‐6) has multiple immunological effects on a wide variety of cells and tissues. The expression of IL‐6 and IL‐6 receptor (IL‐6R) may be important to the pathogenesis of inflammatory bowel disease (IBD).

[1]  Y. Yoshikai,et al.  Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease. , 1998, Gastroenterology.

[2]  Katsuki Ito,et al.  Mucosal interleukin-8 is involved in neutrophil migration and binding to extracellular matrix in inflammatory bowel disease. , 1997, The American journal of gastroenterology.

[3]  P. Ingrand,et al.  IL‐6 and soluble IL‐6 receptors (sIL‐6R and sgp130) in human pleural effusions: massive IL‐6 production independently of underlying diseases , 1997, Clinical and experimental immunology.

[4]  B. Schumacher,et al.  Inflammatory mediators and acute phase proteins in patients with Crohn's disease and ulcerative colitis. , 1997, Hepato-gastroenterology.

[5]  M. Tanimoto,et al.  Lamina propria mononuclear cells express and respond to interleukin-2 differently in Crohn's disease and ulcerative colitis. , 1996, Internal medicine.

[6]  P. Pavli,et al.  Interleukin 8: cells of origin in inflammatory bowel disease. , 1996, Gut.

[7]  S. Akira,et al.  Interleukin-6 family of cytokines and gp130. , 1995, Blood.

[8]  N. Kohno,et al.  Evaluation of soluble IL‐6 receptor concentration in serum and epithelial lining fluid from patients with interstitial lung diseases , 1995, Clinical and experimental immunology.

[9]  K. Tanikawa,et al.  Soluble interleukin-6 receptors in inflammatory bowel disease: relation to circulating interleukin-6. , 1995, Gut.

[10]  S. Albani,et al.  Serum soluble interleukin 6 (IL-6) receptor and IL-6/soluble IL-6 receptor complex in systemic juvenile rheumatoid arthritis. , 1994, The Journal of clinical investigation.

[11]  R. Sartor,et al.  Cytokines in intestinal inflammation: pathophysiological and clinical considerations. , 1994, Gastroenterology.

[12]  R. Macdermott,et al.  Enhand secretion of tumour necrosis factor‐alpha, IL‐6, and IL‐1β by isolated lamina ropria monouclear cells from patients with ulcretive cilitis and Crohn's disease , 1993 .

[13]  G. Yancopoulos,et al.  Soluble forms of the interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. , 1993, Blood.

[14]  J. Hyams,et al.  Relationship of functional and antigenic interleukin 6 to disease activity in inflammatory bowel disease. , 1993, Gastroenterology.

[15]  K. Batts,et al.  Cyclosporine enemas for treatment-resistant, mildly to moderately active, left-sided ulcerative colitis. , 1993, The American journal of gastroenterology.

[16]  B. Klein,et al.  Increased and highly stable levels of functional soluble interleukin‐6 receptor in sera of patients with monoclonal gammopathy , 1993, European journal of immunology.

[17]  S. Schreiber,et al.  Enhanced secretion of tumour necrosis factor-alpha, IL-6, and IL-1 beta by isolated lamina propria mononuclear cells from patients with ulcerative colitis and Crohn's disease. , 1993, Clinical and experimental immunology.

[18]  J A Walker-Smith,et al.  Interleukin-2- and interferon-gamma-secreting T cells in normal and diseased human intestinal mucosa. , 1993, Immunology.

[19]  D. Jewell,et al.  Detection of mRNAs for macrophage products in inflammatory bowel disease by in situ hybridisation. , 1992, Gut.

[20]  T. Hirano,et al.  Interleukin-6 receptor and signals. , 1992, Chemical immunology.

[21]  C. Fiocchi,et al.  Soluble interleukin 2 and CD8 and CD4 receptors in inflammatory bowel disease. , 1992, Gastroenterology.

[22]  T. Bayless,et al.  Increased interleukin-2 messenger RNA in the intestinal mucosal lesions of Crohn's disease but not ulcerative colitis. , 1992, Gastroenterology.

[23]  T. Hirano,et al.  Soluble Interleukin‐6 Receptor Is Released from Receptor‐bearing Cell Lines in vitro , 1992, Japanese journal of cancer research : Gann.

[24]  K. Yasukawa,et al.  Human soluble IL-6 receptor: its detection and enhanced release by HIV infection. , 1992, Journal of immunology.

[25]  A. Kuroiwa,et al.  Phenotypic and functional analysis of lamina propria mononuclear cells from colonoscopic biopsy specimens in patients with ulcerative colitis. , 1992, The American journal of gastroenterology.

[26]  J. Schölmerich,et al.  Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. , 1992, Gastroenterology.

[27]  K. Weinberg,et al.  Defining protective responses to pathogens: cytokine profiles in leprosy lesions. , 1991, Science.

[28]  C. Herfarth,et al.  Soluble interleukin-2 receptor, interleukin-6 and interleukin-1 beta in patients with Crohn's disease and ulcerative colitis: preoperative levels and postoperative changes of serum concentrations. , 1992, Digestion.

[29]  C. Hawkey,et al.  High circulating concentrations of interleukin-6 in active Crohn's disease but not ulcerative colitis. , 1991, Gut.

[30]  R. Macdermott,et al.  Increased activation of isolated intestinal lamina propria mononuclear cells in inflammatory bowel disease. , 1991, Gastroenterology.

[31]  M. Raimondo,et al.  Expression of leukocyte adhesion molecules by mucosal mononuclear phagocytes in inflammatory bowel disease. , 1991, Gastroenterology.

[32]  K. Mitsuyama,et al.  Colonic mucosal interleukin-6 in inflammatory bowel disease. , 1991, Digestion.

[33]  C. Hawkey,et al.  Plasma and tissue interleukin‐2 receptor levels in inflammatory bowel disease , 1990, Clinical and experimental immunology.

[34]  C. Uyttenhove,et al.  Accessory factors involved in murine T cell activation. Distinct roles of interleukin 6, interleukin 1 and tumor necrosis factor , 1990, European journal of immunology.

[35]  A. Dhillon,et al.  Immunohistological studies of surface antigen on colonic lymphoid cells in normal and inflamed mucosa. Comparison of follicular and lamina propria lymphocytes. , 1990, Gastroenterology.

[36]  T. Hirano,et al.  Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130 , 1989, Cell.

[37]  T. Kishimoto,et al.  The biology of interleukin-6. , 1989, Blood.

[38]  E. Sverdlov,et al.  Genes coding for RNA polymerase β subunit in bacteria , 1988 .

[39]  N. Wright.  Colour atlas of gastrointestinal pathology , 1988, Gut.

[40]  J V Castell,et al.  Plasma clearance, organ distribution and target cells of interleukin-6/hepatocyte-stimulating factor in the rat. , 1988, European journal of biochemistry.

[41]  S. Riley,et al.  Comparison of delayed release 5 aminosalicylic acid (mesalazine) and sulphasalazine in the treatment of mild to moderate ulcerative colitis relapse. , 1988, Gut.

[42]  A Muraguchi,et al.  The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells , 1988, The Journal of experimental medicine.

[43]  S. Clark,et al.  B-cell-stimulatory factor 2 (beta 2 interferon) functions as a second signal for interleukin 2 production by mature murine T cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[44]  P. Lansdorp,et al.  Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells. , 1987, Proceedings of the National Academy of Sciences of the United States of America.

[45]  R. F. Harvey,et al.  A SIMPLE INDEX OF CROHN'S-DISEASE ACTIVITY , 1980, The Lancet.

[46]  G. Peterson,et al.  A simplification of the protein assay method of Lowry et al. which is more generally applicable. , 1977, Analytical biochemistry.