Genetic architecture of epigenetic and neuronal ageing rates in human brain regions
暂无分享,去创建一个
Steve Horvath | Eileen M. Crimmins | Daniel H. Geschwind | Eilis Hannon | M. Levine | S. Horvath | A. Lu | D. Geschwind | J. Mill | K. Lunnon | E. Crimmins | E. Hannon | Ake T. Lu | Jonathan Mill | Katie Lunnon | Morgan E. Levine
[1] Michael Q. Zhang,et al. Integrative analysis of 111 reference human epigenomes , 2015, Nature.
[2] Gustavo Turecki,et al. Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia , 2014, Genome Biology.
[3] Nick C Fox,et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease , 2013, Nature Genetics.
[4] Gabriëlle H S Buitendijk,et al. Seven New Loci Associated with Age-Related Macular Degeneration , 2013, Nature Genetics.
[5] Petr Klemera,et al. A new approach to the concept and computation of biological age , 2006, Mechanisms of Ageing and Development.
[6] Manolis Kellis,et al. Alzheimer's disease: early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci , 2014 .
[7] S. Horvath. DNA methylation age of human tissues and cell types , 2013, Genome Biology.
[8] Suzanne Craft,et al. Insulin resistance syndrome and Alzheimer's disease: Age- and obesity-related effects on memory, amyloid, and inflammation , 2005, Neurobiology of Aging.
[9] Ayellet V. Segrè,et al. Common Inherited Variation in Mitochondrial Genes Is Not Enriched for Associations with Type 2 Diabetes or Related Glycemic Traits , 2010, PLoS genetics.
[10] H. Brenner,et al. Epigenetic age acceleration predicts cancer, cardiovascular, and all-cause mortality in a German case cohort , 2016, Clinical Epigenetics.
[11] Judy H. Cho,et al. Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations , 2015, Nature Genetics.
[12] Sonja W. Scholz,et al. Genome-Wide Association Study reveals genetic risk underlying Parkinson’s disease , 2009, Nature Genetics.
[13] L. Kiemeney,et al. A Comparison of Multivariate Genome-Wide Association Methods , 2014, PloS one.
[14] Steve Horvath,et al. The epigenetic clock is correlated with physical and cognitive fitness in the Lothian Birth Cohort 1936 , 2015, International journal of epidemiology.
[15] D. Bennett,et al. Methylomic profiling implicates cortical deregulation of ANK1 in Alzheimer's disease , 2014, Nature Neuroscience.
[16] Joel Eriksson,et al. FTO genotype is associated with phenotypic variability of body mass index , 2012, Nature.
[17] D. Reich,et al. Principal components analysis corrects for stratification in genome-wide association studies , 2006, Nature Genetics.
[18] Manolis Kellis,et al. Large-scale epigenome imputation improves data quality and disease variant enrichment , 2015, Nature Biotechnology.
[19] S. Horvath,et al. Epigenetic age analysis of children who seem to evade aging , 2015, Aging.
[20] M. MacDonald,et al. Genetic modifiers of Huntington's disease , 2014, Movement disorders : official journal of the Movement Disorder Society.
[21] Steve Horvath,et al. WGCNA: an R package for weighted correlation network analysis , 2008, BMC Bioinformatics.
[22] K. Langa,et al. The Aging, Demographics, and Memory Study: Study Design and Methods , 2005, Neuroepidemiology.
[23] ENCODEConsortium,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[24] P. Visscher,et al. Estimating missing heritability for disease from genome-wide association studies. , 2011, American journal of human genetics.
[25] J. Vaupel,et al. DNA methylation age is associated with mortality in a longitudinal Danish twin study , 2015, Aging cell.
[26] Tanya M. Teslovich,et al. Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.
[27] Jun S. Liu,et al. The Genotype-Tissue Expression (GTEx) pilot analysis: Multitissue gene regulation in humans , 2015, Science.
[28] Jennifer S. Woo,et al. The cerebellum ages slowly according to the epigenetic clock , 2015, Aging.
[29] S. Horvath,et al. Increased epigenetic age and granulocyte counts in the blood of Parkinson's disease patients , 2015, Aging.
[30] S. Horvath,et al. Huntington's disease accelerates epigenetic aging of human brain and disrupts DNA methylation levels , 2016, Aging.
[31] A Hofman,et al. Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949) , 2015, Molecular Psychiatry.
[32] A. Singleton,et al. Genetic variability in the regulation of gene expression in ten regions of the human brain , 2014, Nature Neuroscience.
[33] Lewis H Kuller,et al. Midlife and late-life obesity and the risk of dementia: cardiovascular health study. , 2009, Archives of neurology.
[34] Steve Horvath,et al. Accelerated epigenetic aging in Down syndrome , 2015, Aging cell.
[35] N. Wray,et al. A mega-analysis of genome-wide association studies for major depressive disorder , 2013, Molecular Psychiatry.
[36] Claude Bouchard,et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance , 2012, Nature Genetics.
[37] J. Schneider,et al. Overview and findings from the religious orders study. , 2012, Current Alzheimer research.
[38] Michael Boehnke,et al. LocusZoom: regional visualization of genome-wide association scan results , 2010, Bioinform..
[39] R. Goodman,et al. Aging in the United States: opportunities and challenges for public health. , 2012, American journal of public health.
[40] Naomi R. Wray,et al. Statistical Power to Detect Genetic (Co)Variance of Complex Traits Using SNP Data in Unrelated Samples , 2014, PLoS genetics.
[41] Jutta Gampe,et al. Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age , 2014, Human molecular genetics.
[42] S. Horvath,et al. HIV-1 Infection Accelerates Age According to the Epigenetic Clock , 2015, The Journal of infectious diseases.
[43] M. Levine,et al. Epigenetic age of the pre-frontal cortex is associated with neuritic plaques, amyloid load, and Alzheimer’s disease related cognitive functioning , 2015, Aging.
[44] Luigi Ferrucci,et al. Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain , 2010, PLoS genetics.
[45] Ron Brookmeyer,et al. Dementia incidence continues to increase with age in the oldest old: The 90+ study , 2010, Annals of neurology.
[46] Yun Li,et al. METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..
[47] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[48] Mark R Cookson,et al. Distinct DNA methylation changes highly correlated with chronological age in the human brain. , 2011, Human molecular genetics.
[49] R. Dolmetsch,et al. Molecular mechanisms of autism: a possible role for Ca2+ signaling , 2007, Current Opinion in Neurobiology.
[50] P. Visscher,et al. Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets , 2016, Nature Genetics.
[51] S. Horvath,et al. DNA methylation age of blood predicts all-cause mortality in later life , 2015, Genome Biology.
[52] Tamara S. Roman,et al. New genetic loci link adipose and insulin biology to body fat distribution , 2014, Nature.
[53] Manolis Kellis,et al. Alzheimery's disease pathology is associated with early alterations in brain DNA methylation at ANK1, BIN1, RHBDF2 and other loci , 2014, Nature Neuroscience.
[54] “Monoallelic germline methylation and sequence variant in the promoter of the RB1 gene: a possible constitutive epimutation in hereditary retinoblastoma” , 2016, Clinical Epigenetics.
[55] M. Levine,et al. An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease , 2016, Genome Biology.
[56] M. Levine,et al. DNA methylation-based measures of biological age: meta-analysis predicting time to death , 2016, Aging.
[57] Ross M. Fraser,et al. A General Approach for Haplotype Phasing across the Full Spectrum of Relatedness , 2014, PLoS genetics.
[58] M. Levine. Modeling the rate of senescence: can estimated biological age predict mortality more accurately than chronological age? , 2013, The journals of gerontology. Series A, Biological sciences and medical sciences.
[59] Jason J. Corneveaux,et al. Genetic susceptibility for Alzheimer disease neuritic plaque pathology. , 2013, JAMA neurology.
[60] J. Schneider,et al. Overview and findings from the rush Memory and Aging Project. , 2012, Current Alzheimer research.
[61] Anton P. Porsteinsson,et al. Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders , 2010, Biological Psychiatry.
[62] M. Dale,et al. Review: Obesity and Alzheimer’s Disease: A Link Between Body Weight and Cognitive Function in Old Age , 2009, American journal of Alzheimer's disease and other dementias.
[63] S. Resnick,et al. Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation , 2015, Molecular Psychiatry.
[64] Martin J. Aryee,et al. A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression , 2013, Epigenetics.
[65] Disorder Working Group. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4 , 2012, Nature Genetics.
[66] Jane S. Paulsen,et al. Identification of Genetic Factors that Modify Clinical Onset of Huntington’s Disease , 2015, Cell.
[67] Steve Horvath,et al. Obesity accelerates epigenetic aging of human liver , 2014, Proceedings of the National Academy of Sciences.
[68] Lijun Cheng,et al. Genetic control of individual differences in gene-specific methylation in human brain. , 2010, American journal of human genetics.
[69] J. Schwartz,et al. Endothelin-converting enzyme-1 is expressed in human cerebral cortex and protects against Alzheimer's disease , 2004, Molecular Psychiatry.
[70] Chuong B. Do,et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease , 2014, Nature Genetics.
[71] Jamie P. Halsall,et al. Aging in the United States , 2012 .
[72] C. Spencer,et al. Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.
[73] P. Visscher,et al. GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.
[74] M. Levine,et al. Menopause accelerates biological aging , 2016, Proceedings of the National Academy of Sciences.
[75] M. Levine,et al. Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum , 2016, Nature Communications.
[76] P. Donnelly,et al. A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies , 2009, PLoS genetics.
[77] Susanne Walitza,et al. Meta-analysis of genome-wide association studies of attention-deficit/hyperactivity disorder. , 2010, Journal of the American Academy of Child and Adolescent Psychiatry.
[78] J. Marchini,et al. Fast and accurate genotype imputation in genome-wide association studies through pre-phasing , 2012, Nature Genetics.
[79] N. Timpson,et al. Using published data in Mendelian randomization: a blueprint for efficient identification of causal risk factors , 2015, European Journal of Epidemiology.
[80] G. Davey Smith,et al. Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression , 2015, International journal of epidemiology.
[81] S. Love,et al. Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease. , 2013, Journal of Alzheimer's disease : JAD.