Immunoglobulin gene rearrangement in acute myelogenous leukemia.

Twenty-one cases of newly diagnosed nonlymphocytic leukemia were subjected to analysis of immunoglobulin gene organization. Although immunoglobulin gene organization is an essential property of B-lineage cells, immunoglobulin gene rearrangement has also been observed in mouse T-cells and occasionally in cultured human T-cell leukemic cells. Here we report the first case of acute myelogenous leukemia in which mu-chain gene rearrangement is demonstrated. This finding provides a further step in our understanding of both normal and abnormal hematopoietic cell differentiation and the heterogeneity of nonlymphocytic leukemia.

[1]  M. Minden,et al.  Immunoglobulin mu-chain gene rearrangement in a patient with T cell acute lymphoblastic leukemia. , 1984, The Journal of clinical investigation.

[2]  T. Waldmann,et al.  Lymphoid blast crises of chronic myelogenous leukemia represent stages in the development of B-cell precursors. , 1983, The New England journal of medicine.

[3]  J. Yunis.  The chromosomal basis of human neoplasia. , 1983, Science.

[4]  M. Greaves,et al.  Immunoglobulin gene organisation and expression in haemopoietic stem cell leukaemia. , 1983, The EMBO journal.

[5]  S. Cory,et al.  Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[6]  T. Waldmann,et al.  Immunoglobulin gene rearrangement and cell surface antigen expression in acute lymphocytic leukemias of T cell and B cell precursor origins. , 1983, The Journal of clinical investigation.

[7]  I. Bernstein,et al.  Current status of the biology and treatment of acute non-lymphocytic leukemia in children (report from the ANLL strategy group of the Children's Cancer Study Group. , 1983, Blood.

[8]  Lawler Sd.  Significance of chromosome abnormalities in leukemia. , 1982 .

[9]  P. D’Eustachio,et al.  Immunoglobulin heavy chain gene rearrangement and transcription in murine T cell hybrids and T lymphomas. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[10]  T. Waldmann,et al.  Clustered arrangement of immunoglobulin λ constant region genes in man , 1981, Nature.

[11]  Ulrich Siebenlist,et al.  Structure of the human immunoglobulin μ locus: Characterization of embryonic and rearranged J and D genes , 1981, Cell.

[12]  G. Klein.  The role of gene dosage and genetic transpositions in carcinogenesis , 1981, Nature.

[13]  T. Waldmann,et al.  Developmental hierarchy of immunoglobulin gene rearrangements in human leukemic pre-B-cells. , 1981, Proceedings of the National Academy of Sciences of the United States of America.

[14]  C. Milstein,et al.  Human immunoglobulin heavy chain genes: evolutionary comparisons of C mu, C delta and C gamma genes and associated switch sequences. , 1981, Nucleic acids research.

[15]  J. Adamson,et al.  Acute nonlymphocytic leukemia: heterogeneity of stem cell origin. , 1981, Blood.

[16]  J. Seidman,et al.  Cloned human and mouse kappa immunoglobulin constant and J region genes conserve homology in functional segments , 1980, Cell.

[17]  S. Collins,et al.  Continuous growth and differentiation of human myeloid leukaemic cells in suspension culture , 1977, Nature.

[18]  P Berg,et al.  Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I. , 1977, Journal of molecular biology.

[19]  H. Gralnick,et al.  Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group , 1976, British journal of haematology.

[20]  E. Southern.  Detection of specific sequences among DNA fragments separated by gel electrophoresis. , 1975, Journal of molecular biology.

[21]  C. Lozzio,et al.  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. , 1975, Blood.