Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6

[1]  Christof Niehrs,et al.  Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt/β-catenin signalling , 2000, Current Biology.

[2]  A. Glinka,et al.  The role of Xenopus dickkopf1 in prechordal plate specification and neural patterning. , 2000, Development.

[3]  J. Mccoy,et al.  Different activities of the frizzled-related proteins frzb2 and sizzled2 during Xenopus anteroposterior patterning. , 2000, Developmental biology.

[4]  H. Lehrach,et al.  Zebrafish Dkk1, induced by the pre-MBT Wnt signaling, is secreted from the prechordal plate and patterns the anterior neural plate , 2000, Mechanisms of Development.

[5]  Wolfgang Driever,et al.  Repressor activity of Headless/Tcf3 is essential for vertebrate head formation , 2000, Nature.

[6]  Yoichi Kato,et al.  LDL-receptor-related proteins in Wnt signal transduction , 2000, Nature.

[7]  William C. Skarnes,et al.  An LDL-receptor-related protein mediates Wnt signalling in mice , 2000, Nature.

[8]  Andrew Tomlinson,et al.  arrow encodes an LDL-receptor-related protein essential for Wingless signalling , 2000, Nature.

[9]  E. D. De Robertis,et al.  A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists Crescent and Frzb-1 , 2000, Mechanisms of Development.

[10]  M. Taira,et al.  Xenopus crescent encoding a Frizzled-like domain is expressed in the Spemann organizer and pronephros , 2000, Mechanisms of Development.

[11]  J. Riou,et al.  Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis. , 2000, Development.

[12]  R. Nusse,et al.  Pathway specificity by the bifunctional receptor frizzled is determined by affinity for wingless. , 2000, Molecular cell.

[13]  S. Sokol,et al.  A role for Wnts in morpho-genesis and tissue polarity , 2000, Nature Cell Biology.

[14]  J. Smith,et al.  Xwnt11 is a target of Xenopus Brachyury: regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway. , 2000, Development.

[15]  Scott E. Fraser,et al.  Dishevelled controls cell polarity during Xenopus gastrulation , 2000, Nature.

[16]  Robert Geisler,et al.  Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation , 2000, Nature.

[17]  R. Moon,et al.  Ca2+/Calmodulin-dependent Protein Kinase II Is Stimulated by Wnt and Frizzled Homologs and Promotes Ventral Cell Fates in Xenopus* , 2000, The Journal of Biological Chemistry.

[18]  H. Steinbeisser,et al.  Xenopus frizzled 7 can act in canonical and non-canonical Wnt signaling pathways: implications on early patterning and morphogenesis , 2000, Mechanisms of Development.

[19]  A. Üren,et al.  Secreted Frizzled-related Protein-1 Binds Directly to Wingless and Is a Biphasic Modulator of Wnt Signaling* , 2000, The Journal of Biological Chemistry.

[20]  Y. Shi,et al.  Neuralization of the Xenopus Embryo by Inhibition of p300/ CREB-Binding Protein Function , 1999, The Journal of Neuroscience.

[21]  Joachim Herz,et al.  Direct Binding of Reelin to VLDL Receptor and ApoE Receptor 2 Induces Tyrosine Phosphorylation of Disabled-1 and Modulates Tau Phosphorylation , 1999, Neuron.

[22]  K. Robison,et al.  Functional and structural diversity of the human Dickkopf gene family. , 1999, Gene.

[23]  A. Poustka,et al.  Dickkopf genes are co-ordinately expressed in mesodermal lineages , 1999, Mechanisms of Development.

[24]  C. Niehrs,et al.  Head in the WNT: the molecular nature of Spemann's head organizer. , 1999, Trends in genetics : TIG.

[25]  M. Kraus,et al.  Isolation and Biochemical Characterization of the Human Dkk-1 Homologue, a Novel Inhibitor of Mammalian Wnt Signaling* , 1999, The Journal of Biological Chemistry.

[26]  T. Pramila,et al.  Interaction of Frizzled Related Protein (FRP) with Wnt Ligands and the Frizzled Receptor Suggests Alternative Mechanisms for FRP Inhibition of Wnt Signaling* , 1999, The Journal of Biological Chemistry.

[27]  J. Nathans,et al.  A new secreted protein that binds to Wnt proteins and inhibits their activites , 1999, Nature.

[28]  J. Nathans,et al.  Biochemical characterization of Wnt-frizzled interactions using a soluble, biologically active vertebrate Wnt protein. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  T. Bouwmeester,et al.  The head inducer Cerberus is a multifunctional antagonist of Nodal, BMP and Wnt signals , 1999, Nature.

[30]  S. Sokol,et al.  Functional and biochemical interactions of Wnts with FrzA, a secreted Wnt antagonist. , 1998, Development.

[31]  N. Perrimon,et al.  Frizzled signaling and the developmental control of cell polarity. , 1998, Trends in Genetics.

[32]  M. Deardorff,et al.  Frizzled-8 is expressed in the Spemann organizer and plays a role in early morphogenesis. , 1998, Development.

[33]  R. Moon,et al.  From cortical rotation to organizer gene expression: toward a molecular explanation of axis specification in Xenopus , 1998, BioEssays : news and reviews in molecular, cellular and developmental biology.

[34]  C. Niehrs,et al.  Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction , 1998, Nature.

[35]  A. Brown,et al.  Transformation by Wnt family proteins correlates with regulation of beta-catenin. , 1997, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[36]  J. Heasman.  Patterning the Xenopus blastula. , 1997, Development.

[37]  M. Kessel,et al.  Patterning of the chick forebrain anlage by the prechordal plate. , 1997, Development.

[38]  C. Niehrs,et al.  Head induction by simultaneous repression of Bmp and Wnt signalling in Xenopus , 1997, Nature.

[39]  H. Varmus,et al.  Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[40]  P. Nieuwkoop.  Short historical survey of pattern formation in the endo-mesoderm and the neural anlage in the vertebrates: the role of vertical and planar inductive actions , 1997, Cellular and Molecular Life Sciences CMLS.

[41]  J. Nathans,et al.  A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[42]  F. Luyten,et al.  Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8 , 1997, Cell.

[43]  T. Bouwmeester,et al.  Frzb-1 Is a Secreted Antagonist of Wnt Signaling Expressed in the Spemann Organizer , 1997, Cell.

[44]  J. Nathans,et al.  A Member of the Frizzled Protein Family Mediating Axis Induction by Wnt-5A , 1997, Science.

[45]  Y. Sasai,et al.  Ectodermal patterning in vertebrate embryos. , 1997, Developmental biology.

[46]  Y. Rao,et al.  A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. , 1997, Development.

[47]  T. Bouwmeester,et al.  Cerberus is a head-inducing secreted factor expressed in the anterior endoderm of Spemann's organizer , 1996, Nature.

[48]  R. Moon,et al.  Activities of the Wnt-1 class of secreted signaling factors are antagonized by the Wnt-5A class and by a dominant negative cadherin in early Xenopus development , 1996, The Journal of cell biology.

[49]  Y. Sasai,et al.  Xenopus chordin: A novel dorsalizing factor activated by organizer-specific homeobox genes , 1994, Cell.

[50]  N. Ueno,et al.  A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Flanagan,et al.  Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases , 1994, Cell.

[52]  J. Graff,et al.  Studies with a Xenopus BMP receptor suggest that ventral mesoderm-inducing signals override dorsal signals in vivo , 1994, Cell.

[53]  D. Melton,et al.  Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity , 1994, Cell.

[54]  D. Gubb.  Genes controlling cellular polarity in Drosophila. , 1993, Development (Cambridge, England). Supplement.

[55]  J. E. Howard,et al.  Analysis of gastrulation: different types of gastrulation movement are induced by different mesoderm-inducing factors in Xenopus laevis , 1993, Mechanisms of Development.

[56]  S. Gilbert,et al.  Spemann's organizer: models and molecules , 1993, Mechanisms of Development.

[57]  P. Adler.  The genetic control of tissue polarity in Drosophila , 1992, BioEssays : news and reviews in molecular, cellular and developmental biology.

[58]  William C. Smith,et al.  Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos , 1992, Cell.

[59]  K. Van Nimmen,et al.  Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A , 1990, Nature.

[60]  R. Irwin.  The Nature of Development , 2002 .

[61]  T. Hirano,et al.  Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. , 2000, Developmental biology.

[62]  R. Nusse,et al.  Mechanisms of Wnt signaling in development. , 1998, Annual review of cell and developmental biology.

[63]  J. Gerhart,et al.  Formation and function of Spemann's organizer. , 1997, Annual review of cell and developmental biology.

[64]  H. Spemann.  Embryonic development and induction , 1938 .