Abnormal Glucose Metabolism in Alzheimer’s Disease: Relation to Autophagy/Mitophagy and Therapeutic Approaches

[1]  D. Westaway,et al.  Bioenergetic Mechanisms in Astrocytes May Contribute to Amyloid Plaque Deposition and Toxicity* , 2015, The Journal of Biological Chemistry.

[2]  T. Arnould,et al.  Heat-Modified Citrus Pectin Induces Apoptosis-Like Cell Death and Autophagy in HepG2 and A549 Cancer Cells , 2015, PloS one.

[3]  Yaling Han,et al.  CREG1 ameliorates myocardial fibrosis associated with autophagy activation and Rab7 expression. , 2015, Biochimica et biophysica acta.

[4]  F. Guma,et al.  The Interplay Between Apoptosis, Mitophagy and Mitochondrial Biogenesis Induced by Resveratrol Can Determine Activated Hepatic Stellate Cells Death or Survival , 2015, Cell Biochemistry and Biophysics.

[5]  H. Szeto,et al.  Mitochondrial Pharmacology: Its Future Is Now , 2014, Clinical pharmacology and therapeutics.

[6]  D. Kass,et al.  Parkin‐independent mitophagy requires Drp1 and maintains the integrity of mammalian heart and brain , 2014, The EMBO journal.

[7]  Shufeng Zhou,et al.  Bardoxolone methyl (CDDO-Me) as a therapeutic agent: an update on its pharmacokinetic and pharmacodynamic properties , 2014, Drug design, development and therapy.

[8]  E. Michelakis,et al.  A Nuclear Pyruvate Dehydrogenase Complex Is Important for the Generation of Acetyl-CoA and Histone Acetylation , 2014, Cell.

[9]  T. Dawson,et al.  Parkin and PINK1: much more than mitophagy , 2014, Trends in Neurosciences.

[10]  S. Chakrabarti,et al.  Dopamine Cytotoxicity Involves Both Oxidative and Nonoxidative Pathways in SH-SY5Y Cells: Potential Role of Alpha-Synuclein Overexpression and Proteasomal Inhibition in the Etiopathogenesis of Parkinson's Disease , 2014, Parkinson's disease.

[11]  M. Karbowski,et al.  Drp1 is dispensable for apoptotic cytochrome c release in primed MCF10A and fibroblast cells but affects Bcl‐2 antagonist‐induced respiratory changes , 2014, British journal of pharmacology.

[12]  Roberto Annunziata,et al.  Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders , 2014, TheScientificWorldJournal.

[13]  Yan Cao,et al.  Alternative messenger RNA splicing of autophagic gene Beclin 1 in human B-cell acute lymphoblastic leukemia cells. , 2014, Asian Pacific journal of cancer prevention : APJCP.

[14]  A. Attie,et al.  A Role for Peroxisome Proliferator-Activated Receptor &ggr; Coactivator-1 in the Control of Mitochondrial Dynamics During Postnatal Cardiac Growth , 2014, Circulation research.

[15]  Qiang Li,et al.  Rapamycin attenuates mitochondrial dysfunction via activation of mitophagy in experimental ischemic stroke. , 2014, Biochemical and biophysical research communications.

[16]  N. Turner,et al.  Mitochondrial Stress Signaling Promotes Cellular Adaptations , 2014, International journal of cell biology.

[17]  Eric H. Baehrecke,et al.  Self-consumption: the interplay of autophagy and apoptosis , 2014, Nature Reviews Molecular Cell Biology.

[18]  S. Archer,et al.  Dynamin‐related protein 1 (Drp1)‐mediated diastolic dysfunction in myocardial ischemia‐reperfusion injury: therapeutic benefits of Drp1 inhibition to reduce mitochondrial fission , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[19]  F. Middleton,et al.  HRES-1/Rab4-mediated depletion of Drp1 impairs mitochondrial homeostasis and represents a target for treatment in SLE , 2013, Annals of the rheumatic diseases.

[20]  A. Cuervo,et al.  Chaperone-mediated autophagy: roles in disease and aging , 2013, Cell Research.

[21]  M. Sheikh,et al.  Metabolic Stress and Disorders Related to Alterations in Mitochondrial Fission or Fusion. , 2013, Molecular and cellular pharmacology.

[22]  Simon C Watkins,et al.  Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells , 2013, Nature Cell Biology.

[23]  E. Schon,et al.  Mitochondria-associated ER membranes in Alzheimer disease , 2013, Molecular and Cellular Neuroscience.

[24]  M. Beal,et al.  Mitochondria targeted therapeutic approaches in Parkinson's and Huntington's diseases , 2013, Molecular and Cellular Neuroscience.

[25]  Yingming Zhao,et al.  SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. , 2013, Molecular cell.

[26]  Yasushi Hiraoka,et al.  Autophagosomes form at ER–mitochondria contact sites , 2013, Nature.

[27]  Danica Chen,et al.  The sirtuins, oxidative stress and aging: an emerging link , 2013, Aging.

[28]  T. Schwarz,et al.  The pathways of mitophagy for quality control and clearance of mitochondria , 2012, Cell Death and Differentiation.

[29]  L. Scorrano,et al.  Mitochondrial morphology in mitophagy and macroautophagy. , 2013, Biochimica et biophysica acta.

[30]  G. Kaushal.  Autophagy protects proximal tubular cells from injury and apoptosis. , 2012, Kidney international.

[31]  M. Frank,et al.  Mitophagy is triggered by mild oxidative stress in a mitochondrial fission dependent manner. , 2012, Biochimica et biophysica acta.

[32]  M. DiFiglia,et al.  The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation , 2012, PloS one.

[33]  M. Jacobson,et al.  Defects in Mitochondrial Fission Protein Dynamin-Related Protein 1 Are Linked to Apoptotic Resistance and Autophagy in a Lung Cancer Model , 2012, PloS one.

[34]  M. Beal,et al.  Mitochondrial Dysfunction in Neurodegenerative Diseases , 2012, Journal of Pharmacology and Experimental Therapeutics.

[35]  W. Durante,et al.  Activation of AMP-Activated Protein Kinase Inhibits the Proliferation of Human Endothelial Cells , 2012, Journal of Pharmacology and Experimental Therapeutics.

[36]  G. Gibson,et al.  Deficits in the mitochondrial enzyme α-ketoglutarate dehydrogenase lead to Alzheimer's disease-like calcium dysregulation , 2012, Neurobiology of Aging.

[37]  P. Reddy,et al.  Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage. , 2012, Human molecular genetics.

[38]  D. Green,et al.  Mitochondria and cell signalling , 2012, Journal of Cell Science.

[39]  B. Miller,et al.  Cognition, glucose metabolism and amyloid burden in Alzheimer's disease , 2012, Neurobiology of Aging.

[40]  Hyoung-Gon Lee,et al.  Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease , 2012, Journal of neurochemistry.

[41]  J. Pyo,et al.  Molecules and their functions in autophagy , 2012, Experimental & Molecular Medicine.

[42]  Vishwanath T. Anekonda,et al.  Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease. , 2012, Human molecular genetics.

[43]  G. Gibson,et al.  Brain [U‐13C]glucose metabolism in mice with decreased α‐ketoglutarate dehydrogenase complex activity , 2011, Journal of neuroscience research.

[44]  Youngil Lee,et al.  Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes. , 2011, American journal of physiology. Heart and circulatory physiology.

[45]  P. Reddy,et al.  Impaired mitochondrial dynamics and abnormal interaction of amyloid beta with mitochondrial protein Drp1 in neurons from patients with Alzheimer's disease: implications for neuronal damage. , 2011, Human molecular genetics.

[46]  T. Montine,et al.  Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease , 2011, Alzheimer's Research & Therapy.

[47]  Hui Yang,et al.  Silencing of PINK1 induces mitophagy via mitochondrial permeability transition in dopaminergic MN9D cells , 2011, Brain Research.

[48]  O. Shirihai,et al.  The interplay between mitochondrial dynamics and mitophagy. , 2011, Antioxidants & redox signaling.

[49]  T. Dawson,et al.  PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease , 2011, Cell.

[50]  Ishita Guha Thakurta,et al.  Mitochondrial Dysfunction during Brain Aging: Role of Oxidative Stress and Modulation by Antioxidant Supplementation. , 2011, Aging and disease.

[51]  Sonja Hess,et al.  Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy , 2011, Human molecular genetics.

[52]  Min Liu,et al.  Parkin Ubiquitinates Drp1 for Proteasome-dependent Degradation , 2011, The Journal of Biological Chemistry.

[53]  Benedikt Westermann,et al.  Mitochondrial fusion and fission in cell life and death , 2010, Nature Reviews Molecular Cell Biology.

[54]  John X. Morris,et al.  Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ) deposition , 2010, Proceedings of the National Academy of Sciences.

[55]  D. Holtzman,et al.  Biomarkers in translational research of Alzheimer’s Disease , 2010, Neuropharmacology.

[56]  G. Rotilio,et al.  Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. , 2010, The Journal of biological chemistry.

[57]  Tian-Le Xu,et al.  Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. , 2010, Brain : a journal of neurology.

[58]  R. Cappai,et al.  α‐Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease , 2010, FEBS letters.

[59]  D. Wallace,et al.  Mitochondrial energetics and therapeutics. , 2010, Annual review of pathology.

[60]  G. Perry,et al.  Mitochondria: a therapeutic target in neurodegeneration. , 2010, Biochimica et biophysica acta.

[61]  G. Rotilio,et al.  Peroxisome Proliferator-activated Receptor Co-activator 1 (PGC-1 ) and Sirtuin 1 (SIRT1) Reside in Mitochondria POSSIBLE DIRECT FUNCTION IN MITOCHONDRIAL BIOGENESIS*□ , 2010 .

[62]  Ted M. Dawson,et al.  PINK1-dependent recruitment of Parkin to mitochondria in mitophagy , 2009, Proceedings of the National Academy of Sciences.

[63]  E. Rugarli,et al.  Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1 , 2009, The Journal of cell biology.

[64]  M. Beal.  Therapeutic approaches to mitochondrial dysfunction in Parkinson's disease. , 2009, Parkinsonism & related disorders.

[65]  R. Youle,et al.  The role of mitochondria in apoptosis*. , 2009, Annual review of genetics.

[66]  D. Chan,et al.  Mitochondrial dynamics–fusion, fission, movement, and mitophagy–in neurodegenerative diseases , 2009, Human molecular genetics.

[67]  M. Beal,et al.  Thiamine deficiency induces oxidative stress and exacerbates the plaque pathology in Alzheimer's mouse model , 2009, Neurobiology of Aging.

[68]  P. Codogno,et al.  Autophagy: Regulation and role in disease , 2009, Critical reviews in clinical laboratory sciences.

[69]  Satoshi O. Suzuki,et al.  Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice , 2009, Nature Cell Biology.

[70]  Ji Zhang,et al.  Role of BNIP3 and NIX in cell death, autophagy, and mitophagy , 2009, Cell Death and Differentiation.

[71]  C. Fernandes‐Santos,et al.  Pan-PPAR agonist beneficial effects in overweight mice fed a high-fat high-sucrose diet. , 2009, Nutrition.

[72]  G. Gibson,et al.  Mild reduction in the activity of the α‐ketoglutarate dehydrogenase complex elevates GABA shunt and glycolysis , 2009, Journal of neurochemistry.

[73]  M. Karbowski,et al.  Mitochondrial fusion and division: Regulation and role in cell viability. , 2009, Seminars in cell & developmental biology.

[74]  A. Godzik,et al.  S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury , 2009, Science.

[75]  K. Fukunaga,et al.  p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum , 2009, Autophagy.

[76]  M. Beal,et al.  Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's disease , 2009, Neurochemistry International.

[77]  P. Codogno,et al.  Macroautophagy signaling and regulation. , 2009, Current topics in microbiology and immunology.

[78]  O. Shirihai,et al.  Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. , 2008, Biochimica et biophysica acta.

[79]  M. Beal,et al.  Influence of mitochondrial enzyme deficiency on adult neurogenesis in mouse models of neurodegenerative diseases , 2008, Neuroscience.

[80]  Fernando J. Pineda,et al.  Mitochondrial fission and fusion dynamics: the long and short of it , 2008, Cell Death and Differentiation.

[81]  Robin Mathew,et al.  Role of autophagy in cancer , 2007, Nature Reviews Cancer.

[82]  Guido Kroemer,et al.  Self-eating and self-killing: crosstalk between autophagy and apoptosis , 2007, Nature Reviews Molecular Cell Biology.

[83]  J. Estaquier,et al.  Inhibiting Drp1-mediated mitochondrial fission selectively prevents the release of cytochrome c during apoptosis , 2007, Cell Death and Differentiation.

[84]  Huiyun Liang,et al.  Staying Current PGC-1 : a key regulator of energy metabolism , 2006 .

[85]  Jiandie D. Lin,et al.  Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators , 2006, Cell.

[86]  M. Beal,et al.  Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases , 2006, Nature.

[87]  D. Chan.  Mitochondrial fusion and fission in mammals. , 2006, Annual review of cell and developmental biology.

[88]  L. Galluzzi,et al.  Mitochondria as therapeutic targets for cancer chemotherapy , 2006, Oncogene.

[89]  B. Zhivotovsky,et al.  Multiple pathways of cytochrome c release from mitochondria in apoptosis. , 2006, Biochimica et biophysica acta.

[90]  Sónia Sá Santos,et al.  Inhibitors of the α‐ketoglutarate dehydrogenase complex alter [1‐13C]glucose and [U‐13C]glutamate metabolism in cerebellar granule neurons , 2006 .

[91]  M. Guha,et al.  Mitochondria-to-nucleus stress signaling in mammalian cells: nature of nuclear gene targets, transcription regulation, and induced resistance to apoptosis. , 2005, Gene.

[92]  Christoph Handschin,et al.  Metabolic control through the PGC-1 family of transcription coactivators. , 2005, Cell metabolism.

[93]  Parvesh Bubber,et al.  Mitochondrial abnormalities in Alzheimer brain: Mechanistic implications , 2005, Annals of neurology.

[94]  Sue Goo Rhee,et al.  Peroxiredoxin III, a Mitochondrion-specific Peroxidase, Regulates Apoptotic Signaling by Mitochondria* , 2004, Journal of Biological Chemistry.

[95]  T. Dawson,et al.  Nuclear and mitochondrial conversations in cell death: PARP-1 and AIF signaling. , 2004, Trends in pharmacological sciences.

[96]  Parvesh Bubber,et al.  Mice deficient in dihydrolipoamide dehydrogenase show increased vulnerability to MPTP, malonate and 3‐nitropropionic acid neurotoxicity , 2004, Journal of neurochemistry.

[97]  Hsueh‐Meei Huang,et al.  Inhibition of α‐ketoglutarate dehydrogenase complex promotes cytochrome c release from mitochondria, caspase‐3 activation, and necrotic cell death , 2003, Journal of neuroscience research.

[98]  V. Borutaite,et al.  Inhibition of mitochondrial permeability transition prevents mitochondrial dysfunction, cytochrome c release and apoptosis induced by heart ischemia. , 2003, Journal of molecular and cellular cardiology.

[99]  P. Puigserver,et al.  Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. , 2003, Endocrine reviews.

[100]  A. Halestrap,et al.  The permeability transition pore complex: another view. , 2002, Biochimie.

[101]  T. Langer,et al.  AAA proteases of mitochondria: quality control of membrane proteins and regulatory functions during mitochondrial biogenesis. , 2001, Biochemical Society transactions.

[102]  A. M. van der Bliek,et al.  Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cells. , 2001, Molecular biology of the cell.

[103]  G. Amuthan,et al.  Mitochondria‐to‐nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion , 2001, The EMBO journal.

[104]  N D Marchenko,et al.  Death Signal-induced Localization of p53 Protein to Mitochondria , 2000, The Journal of Biological Chemistry.

[105]  A Büki,et al.  Cytochrome c Release and Caspase Activation in Traumatic Axonal Injury , 2000, The Journal of Neuroscience.

[106]  L. Ghibelli,et al.  Glutathione depletion causes cytochrome c release even in the absence of cell commitment to apoptosis , 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.