A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.
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Michael A. Kovacs | Ashley A. Jermusyk | S. Grant | K. Brown | M. Iles | S. Chanock | A. Goldstein | R. Thakur | R. Chari | G. Merlino | K. Jones | A. Chesi | A. Wells | M. Landi | Hayley A. Sowards | Tongwu Zhang | M. Law | Jiyeon Choi | Lea Jessop | Mai Xu | Matthew E. Johnson | Matthew E Johnson | Herbert Higson | Rebecca C. Hennessey | Lindsey Mehl | Timothy A. Myers | H. Michael | Patricia C. Bunda
[1] W. Haefeli,et al. IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression , 2020, Cell.
[2] T. Tüting,et al. The aryl hydrocarbon receptor promotes inflammation‐induced dedifferentiation and systemic metastatic spread of melanoma cells , 2020, International journal of cancer.
[3] Michael A. Kovacs,et al. Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma , 2020, Nature Communications.
[4] Blair H. Smith,et al. Genome-wide association meta-analyses combining multiple risk phenotypes provides insights into the genetic architecture of cutaneous melanoma susceptibility , 2020, Nature Genetics.
[5] D. R. Lewis,et al. Annual report to the nation on the status of cancer, part I: National cancer statistics , 2020, Cancer.
[6] C. Esser,et al. Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis , 2019, International journal of molecular sciences.
[7] Anshul Kundaje,et al. The ENCODE Blacklist: Identification of Problematic Regions of the Genome , 2019, Scientific Reports.
[8] S. MacGregor,et al. Combined analysis of keratinocyte cancers identifies novel genome-wide loci , 2019, Human molecular genetics.
[9] Ting Wang,et al. WashU Epigenome Browser update 2019 , 2019, Nucleic Acids Res..
[10] K. Tarte,et al. Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma , 2018, Nature Communications.
[11] Kathleen A Cronin,et al. Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics , 2018, Cancer.
[12] Xiaoquan Wen,et al. Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics , 2018, bioRxiv.
[13] A. Uitterlinden,et al. Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure , 2018, Nature Communications.
[14] Jianxin Shi,et al. Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes , 2017, bioRxiv.
[15] Christopher Wilks,et al. Scaling read aligners to hundreds of threads on general-purpose processors , 2017, bioRxiv.
[16] David M. Evans,et al. Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways , 2017, Nature Communications.
[17] Michael A. Kovacs,et al. A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF , 2017, Nature Genetics.
[18] Alexander Gusev,et al. Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. , 2017, American journal of human genetics.
[19] Christopher I. Amos,et al. Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma , 2017, Oncotarget.
[20] K. Singh,et al. Aryl Hydrocarbon Receptor Activation Contributes to Benzanthrone-Induced Hyperpigmentation via Modulation of Melanogenic Signaling Pathways. , 2017, Chemical research in toxicology.
[21] Brian C. Capell,et al. The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. , 2016, The Journal of investigative dermatology.
[22] Peter Kraft,et al. Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma , 2022 .
[23] Xiaoquan Wen,et al. Efficient Integrative Multi-SNP Association Analysis using Deterministic Approximation of Posteriors , 2015, bioRxiv.
[24] G. Parmigiani,et al. Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. , 2016, JAMA.
[25] Meagan E. Sullender,et al. Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 , 2015, Nature Biotechnology.
[26] Jonathan M. Cairns,et al. CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data , 2015, Genome Biology.
[27] Philip A. Ewels,et al. HiCUP: pipeline for mapping and processing Hi-C data , 2015, F1000Research.
[28] Philip A. Ewels,et al. HiCUP: pipeline for mapping and processing Hi-C data , 2015, F1000Research.
[29] Mitchell J. Machiela,et al. LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants , 2015, Bioinform..
[30] C. Esser,et al. The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin Disorders. , 2015, The Journal of investigative dermatology.
[31] Simon G. Coetzee,et al. motifbreakR: an R/Bioconductor package for predicting variant effects at transcription factor binding sites , 2015, Bioinform..
[32] Marko Hočevar,et al. Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma , 2015, Nature Genetics.
[33] G. Church,et al. Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach , 2015, Nature Methods.
[34] Nicholas G. Martin,et al. Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up , 2015, Human Genetics.
[35] Michael Q. Zhang,et al. Integrative analysis of 111 reference human epigenomes , 2015, Nature.
[36] Jun S. Liu,et al. MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens , 2014, Genome Biology.
[37] Eleazar Eskin,et al. Identifying Causal Variants at Loci with Multiple Signals of Association , 2014, Genetics.
[38] Sabine U. Vorrink,et al. Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node. , 2014, Chemico-biological interactions.
[39] Neville E. Sanjana,et al. Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.
[40] B. Stockinger,et al. The aryl hydrocarbon receptor: multitasking in the immune system. , 2014, Annual review of immunology.
[41] X. Bustelo,et al. The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis. , 2013, Carcinogenesis.
[42] H. Kato,et al. Tobacco smoke–induced skin pigmentation is mediated by the aryl hydrocarbon receptor , 2013, Experimental dermatology.
[43] Kelly J. Morris,et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence , 2013, Nature Cell Biology.
[44] Marko Hočevar,et al. A variant in FTO shows association with melanoma risk not due to BMI , 2013, Nature Genetics.
[45] Job Dekker,et al. Analysis of long-range chromatin interactions using Chromosome Conformation Capture. , 2012, Methods.
[46] K. Kawakami,et al. Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish , 2012, PloS one.
[47] Eurie L. Hong,et al. Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.
[48] ENCODEConsortium,et al. An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.
[49] Steven L Salzberg,et al. Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.
[50] P. Visscher,et al. Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.
[51] Adam A. Margolin,et al. The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.
[52] Jeffrey E. Lee,et al. Genome-wide association study identifies three new melanoma susceptibility loci , 2011, Nature Genetics.
[53] Jeffrey E. Lee,et al. Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3 , 2011, Nature Genetics.
[54] David A. Orlando,et al. The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset , 2011, Nature.
[55] C. Esser,et al. The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning. , 2011, The Journal of investigative dermatology.
[56] C. Esser,et al. The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis , 2010, Pigment cell & melanoma research.
[57] Nicole Soranzo,et al. IRF4 variants have age-specific effects on nevus count and predispose to melanoma. , 2010, American journal of human genetics.
[58] D. Duffy,et al. Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. , 2010, The Journal of investigative dermatology.
[59] J. Malvehy,et al. Genome-wide association study identifies three loci associated with melanoma risk , 2009, Nature Genetics.
[60] T. Spector,et al. Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi , 2009, Nature Genetics.
[61] Qikai Xu,et al. Design of 240,000 orthogonal 25mer DNA barcode probes , 2009, Proceedings of the National Academy of Sciences.
[62] Paolo Vineis,et al. Sequence variants at the TERT-CLPTM1L locus associate with many cancer types , 2009, Nature Genetics.
[63] Clifford A. Meyer,et al. Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.
[64] Kari Stefansson,et al. ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma , 2008, Nature Genetics.
[65] Nils Homer,et al. Common sequence variants on 20q11.22 confer melanoma susceptibility , 2008, Nature Genetics.
[66] G. Perdew,et al. The aryl hydrocarbon receptor complex and the control of gene expression. , 2008, Critical reviews in eukaryotic gene expression.
[67] D. Duffy,et al. Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. , 2007, Human molecular genetics.
[68] Tom H. Pringle,et al. The human genome browser at UCSC. , 2002, Genome research.
[69] R. Halaban,et al. Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.
[70] R. Halaban,et al. Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells , 2000, The Journal of experimental medicine.
[71] J. Elwood. Recent developments in melanoma epidemiology, 1993. , 1993, Melanoma research.