A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.

[1]  W. Haefeli,et al.  IL4I1 Is a Metabolic Immune Checkpoint that Activates the AHR and Promotes Tumor Progression , 2020, Cell.

[2]  T. Tüting,et al.  The aryl hydrocarbon receptor promotes inflammation‐induced dedifferentiation and systemic metastatic spread of melanoma cells , 2020, International journal of cancer.

[3]  Michael A. Kovacs,et al.  Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma , 2020, Nature Communications.

[4]  Blair H. Smith,et al.  Genome-wide association meta-analyses combining multiple risk phenotypes provides insights into the genetic architecture of cutaneous melanoma susceptibility , 2020, Nature Genetics.

[5]  D. R. Lewis,et al.  Annual report to the nation on the status of cancer, part I: National cancer statistics , 2020, Cancer.

[6]  C. Esser,et al.  Role of the Aryl Hydrocarbon Receptor in Environmentally Induced Skin Aging and Skin Carcinogenesis , 2019, International journal of molecular sciences.

[7]  Anshul Kundaje,et al.  The ENCODE Blacklist: Identification of Problematic Regions of the Genome , 2019, Scientific Reports.

[8]  S. MacGregor,et al.  Combined analysis of keratinocyte cancers identifies novel genome-wide loci , 2019, Human molecular genetics.

[9]  Ting Wang,et al.  WashU Epigenome Browser update 2019 , 2019, Nucleic Acids Res..

[10]  K. Tarte,et al.  Sustained activation of the Aryl hydrocarbon Receptor transcription factor promotes resistance to BRAF-inhibitors in melanoma , 2018, Nature Communications.

[11]  Kathleen A Cronin,et al.  Annual Report to the Nation on the Status of Cancer, part I: National cancer statistics , 2018, Cancer.

[12]  Xiaoquan Wen,et al.  Bayesian Multi-SNP Genetic Association Analysis: Control of FDR and Use of Summary Statistics , 2018, bioRxiv.

[13]  A. Uitterlinden,et al.  Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure , 2018, Nature Communications.

[14]  Jianxin Shi,et al.  Cell-type–specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes , 2017, bioRxiv.

[15]  Christopher Wilks,et al.  Scaling read aligners to hundreds of threads on general-purpose processors , 2017, bioRxiv.

[16]  David M. Evans,et al.  Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways , 2017, Nature Communications.

[17]  Michael A. Kovacs,et al.  A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF , 2017, Nature Genetics.

[18]  Alexander Gusev,et al.  Integrating Gene Expression with Summary Association Statistics to Identify Genes Associated with 30 Complex Traits. , 2017, American journal of human genetics.

[19]  Christopher I. Amos,et al.  Two-stage genome-wide association study identifies a novel susceptibility locus associated with melanoma , 2017, Oncotarget.

[20]  K. Singh,et al.  Aryl Hydrocarbon Receptor Activation Contributes to Benzanthrone-Induced Hyperpigmentation via Modulation of Melanogenic Signaling Pathways. , 2017, Chemical research in toxicology.

[21]  Brian C. Capell,et al.  The Senescence-Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. , 2016, The Journal of investigative dermatology.

[22]  Peter Kraft,et al.  Genome-wide association study identifies novel susceptibility loci for cutaneous squamous cell carcinoma , 2022 .

[23]  Xiaoquan Wen,et al.  Efficient Integrative Multi-SNP Association Analysis using Deterministic Approximation of Posteriors , 2015, bioRxiv.

[24]  G. Parmigiani,et al.  Familial Risk and Heritability of Cancer Among Twins in Nordic Countries. , 2016, JAMA.

[25]  Meagan E. Sullender,et al.  Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9 , 2015, Nature Biotechnology.

[26]  Jonathan M. Cairns,et al.  CHiCAGO: robust detection of DNA looping interactions in Capture Hi-C data , 2015, Genome Biology.

[27]  Philip A. Ewels,et al.  HiCUP: pipeline for mapping and processing Hi-C data , 2015, F1000Research.

[28]  Philip A. Ewels,et al.  HiCUP: pipeline for mapping and processing Hi-C data , 2015, F1000Research.

[29]  Mitchell J. Machiela,et al.  LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants , 2015, Bioinform..

[30]  C. Esser,et al.  The Janus-Faced Role of Aryl Hydrocarbon Receptor Signaling in the Skin: Consequences for Prevention and Treatment of Skin Disorders. , 2015, The Journal of investigative dermatology.

[31]  Simon G. Coetzee,et al.  motifbreakR: an R/Bioconductor package for predicting variant effects at transcription factor binding sites , 2015, Bioinform..

[32]  Marko Hočevar,et al.  Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma , 2015, Nature Genetics.

[33]  G. Church,et al.  Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach , 2015, Nature Methods.

[34]  Nicholas G. Martin,et al.  Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up , 2015, Human Genetics.

[35]  Michael Q. Zhang,et al.  Integrative analysis of 111 reference human epigenomes , 2015, Nature.

[36]  Jun S. Liu,et al.  MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens , 2014, Genome Biology.

[37]  Eleazar Eskin,et al.  Identifying Causal Variants at Loci with Multiple Signals of Association , 2014, Genetics.

[38]  Sabine U. Vorrink,et al.  Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node. , 2014, Chemico-biological interactions.

[39]  Neville E. Sanjana,et al.  Improved vectors and genome-wide libraries for CRISPR screening , 2014, Nature Methods.

[40]  B. Stockinger,et al.  The aryl hydrocarbon receptor: multitasking in the immune system. , 2014, Annual review of immunology.

[41]  X. Bustelo,et al.  The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis. , 2013, Carcinogenesis.

[42]  H. Kato,et al.  Tobacco smoke–induced skin pigmentation is mediated by the aryl hydrocarbon receptor , 2013, Experimental dermatology.

[43]  Kelly J. Morris,et al.  A complex secretory program orchestrated by the inflammasome controls paracrine senescence , 2013, Nature Cell Biology.

[44]  Marko Hočevar,et al.  A variant in FTO shows association with melanoma risk not due to BMI , 2013, Nature Genetics.

[45]  Job Dekker,et al.  Analysis of long-range chromatin interactions using Chromosome Conformation Capture. , 2012, Methods.

[46]  K. Kawakami,et al.  Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish , 2012, PloS one.

[47]  Eurie L. Hong,et al.  Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.

[48]  ENCODEConsortium,et al.  An Integrated Encyclopedia of DNA Elements in the Human Genome , 2012, Nature.

[49]  Steven L Salzberg,et al.  Fast gapped-read alignment with Bowtie 2 , 2012, Nature Methods.

[50]  P. Visscher,et al.  Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits , 2012, Nature Genetics.

[51]  Adam A. Margolin,et al.  The Cancer Cell Line Encyclopedia enables predictive modeling of anticancer drug sensitivity , 2012, Nature.

[52]  Jeffrey E. Lee,et al.  Genome-wide association study identifies three new melanoma susceptibility loci , 2011, Nature Genetics.

[53]  Jeffrey E. Lee,et al.  Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3 , 2011, Nature Genetics.

[54]  David A. Orlando,et al.  The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset , 2011, Nature.

[55]  C. Esser,et al.  The aryl hydrocarbon receptor mediates UVB radiation-induced skin tanning. , 2011, The Journal of investigative dermatology.

[56]  C. Esser,et al.  The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis , 2010, Pigment cell & melanoma research.

[57]  Nicole Soranzo,et al.  IRF4 variants have age-specific effects on nevus count and predispose to melanoma. , 2010, American journal of human genetics.

[58]  D. Duffy,et al.  Multiple pigmentation gene polymorphisms account for a substantial proportion of risk of cutaneous malignant melanoma. , 2010, The Journal of investigative dermatology.

[59]  J. Malvehy,et al.  Genome-wide association study identifies three loci associated with melanoma risk , 2009, Nature Genetics.

[60]  T. Spector,et al.  Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi , 2009, Nature Genetics.

[61]  Qikai Xu,et al.  Design of 240,000 orthogonal 25mer DNA barcode probes , 2009, Proceedings of the National Academy of Sciences.

[62]  Paolo Vineis,et al.  Sequence variants at the TERT-CLPTM1L locus associate with many cancer types , 2009, Nature Genetics.

[63]  Clifford A. Meyer,et al.  Model-based Analysis of ChIP-Seq (MACS) , 2008, Genome Biology.

[64]  Kari Stefansson,et al.  ASIP and TYR pigmentation variants associate with cutaneous melanoma and basal cell carcinoma , 2008, Nature Genetics.

[65]  Nils Homer,et al.  Common sequence variants on 20q11.22 confer melanoma susceptibility , 2008, Nature Genetics.

[66]  G. Perdew,et al.  The aryl hydrocarbon receptor complex and the control of gene expression. , 2008, Critical reviews in eukaryotic gene expression.

[67]  D. Duffy,et al.  Receptor function, dominant negative activity and phenotype correlations for MC1R variant alleles. , 2007, Human molecular genetics.

[68]  Tom H. Pringle,et al.  The human genome browser at UCSC. , 2002, Genome research.

[69]  R. Halaban,et al.  Endoplasmic reticulum retention is a common defect associated with tyrosinase-negative albinism. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[70]  R. Halaban,et al.  Deregulated E2f Transcriptional Activity in Autonomously Growing Melanoma Cells , 2000, The Journal of experimental medicine.

[71]  J. Elwood Recent developments in melanoma epidemiology, 1993. , 1993, Melanoma research.